Zobrazeno 1 - 10
of 49
pro vyhledávání: '"George Hoppe"'
Autor:
Charandeep Singh, Vincent Tran, Leah McCollum, Youstina Bolok, Kristin Allan, Alex Yuan, George Hoppe, Henri Brunengraber, Jonathan E. Sears
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Prematurely born babies need extra oxygen to survive, but this can cause damage to the eyes and lead to infant blindness. Here the authors show that this hyperoxia changes the metabolism of Müller cells in the retina such that they use up, rather th
Externí odkaz:
https://doaj.org/article/956377e5821140ba84212046f44f2ab9
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 37 (2022)
We asked whether hyperoxia might induce hypomyelination of the corpus callosum, clinically described as periventricular leukomalacia (PVL) of the severely preterm infant. Mouse pups and their nursing dams were placed in 80% oxygen from P4-P8, then re
Externí odkaz:
https://doaj.org/article/516e198bc24346d0b0ecfc2ee8abf5a9
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Here we rank order small molecule inhibitors of hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs) using severity of oxygen induced retinopathy (OIR) as an outcome measure. Dose response analyses in cell cultures of hepatoma (Hep3B), retinal M
Externí odkaz:
https://doaj.org/article/166f130728b74429ad26dca3c5dfc174
Autor:
Eugene A. Podrez, George Hoppe, June O'Neil, Lawrence M. Sayre, Nader Sheibani, Henry F. Hoff
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 9, Pp 1455-1463 (2000)
Oxidation of low density lipoproteins (LDL) induced by incubation with Cu2+ ions results in the formation of a heterogeneous group of aldehydic adducts on lysyl residues (Lys) of apolipoprotein B (apoB) that are thought to be responsible for the upta
Externí odkaz:
https://doaj.org/article/28e45330c05148a2ab17f204cc04c7f0
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
Here we rank order small molecule inhibitors of hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs) using severity of oxygen induced retinopathy (OIR) as an outcome measure. Dose response analyses in cell cultures of hepatoma (Hep3B), retinal M
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Transcriptional analysis of retina protected by hypoxia-inducible factor (HIF) stabilization demonstrates an increase in genes associated with aerobic glycolysis. We hypothesized that since protection is associated with a change in metabolism
Autor:
Youstina Bolok, Vincent Tran, Alex Yuan, Leah McCollum, Henri Brunengraber, George Hoppe, Jonathan E. Sears, Charandeep Singh, Kristin Allan
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Although supplemental oxygen is required to promote survival of severely premature infants, hyperoxia is simultaneously harmful to premature developing tissues such as in the retina. Here we report the effect of hyperoxia on central carbon metabolism
Autor:
Charandeep Singh, Jonathan E. Sears, Amit Sharma, George Hoppe, Vincent Tran, Henri Brunengraber, Youstina Bolok, Weilin Song, Leah McCollum
Publikováno v:
JCI Insight. 4
We determined which metabolic pathways are activated by hypoxia-inducible factor 1–mediated (HIF-1–mediated) protection against oxygen-induced retinopathy (OIR) in newborn mice, the experimental correlate to retinopathy of prematurity, a leading
Autor:
Christine Sonnie, Sarah Worley, Amit Sharma, Dawn Howard, Jonathan E. Sears, George Hoppe, Jon Moore, Ricardo J. Rodriguez, Ankita Shukla
Publikováno v:
JAMA ophthalmology. 137(4)
Importance The Surfactant, Positive Pressure, and Pulse Oximetry Randomized Trial (SUPPORT) demonstrated that static low oxygen saturation decreased retinopathy of prematurity (ROP) but increased mortality compared with static high oxygen saturation
Autor:
Minzhong Yu, George Hoppe, Suzy Yoon, Mary E. Rayborn, Tamara J. Lee, Jonathan E. Sears, John Au, Neal S. Peachey, George Trichonas, M. Julieta Zutel
Publikováno v:
The American Journal of Pathology. 184:1890-1899
Activation of hypoxia-inducible factor (HIF) can prevent oxygen-induced retinopathy in rodents. Here we demonstrate that dimethyloxaloylglycine (DMOG)-induced retinovascular protection is dependent on hepatic HIF-1 because mice deficient in liver-spe