Zobrazeno 1 - 10
of 25
pro vyhledávání: '"George Heavner"'
Publikováno v:
Journal of Molecular Recognition. 25:174-183
There are a number of proteins whose active forms are non-covalent multichain complexes. Therapeutic intervention involving such complexes has been proposed through the use of muteins to form heterostructures. These resulting structures would either
Publikováno v:
International Journal of Peptide and Protein Research. 37:198-209
Four cyclic analogs of thymopentin were synthesized and evaluated for biological activity on the human T cell line CEM. Three of these conformationally restricted analogs were biologically active. The one analog which most closely mimicked the confor
Autor:
Mike Brigham-Burke, Cheryl Blasie, George Heavner, Stephen G. McCarthy, George R. Gunn, Mark R. Cunningham, Bethany Swencki-Underwood, Linda A. Snyder, Theresa J. Goletz, Tara Dougherty
Publikováno v:
Cytokine. 34:114-124
Cytokines in plasmid form can act as potent adjuvants when co-administered with DNA vaccines, resulting in an enhanced immune response to the DNA-encoded antigen. This is true of interleukin-18 (IL-18), which has been shown to serve as an adjuvant in
Autor:
Marian Kruszynski, Nicole Stowell, Raymond Sweet, Ping Tsui, Jinquan Luo, George Heavner, Anuk Das, Jennifer F. Nemeth
Publikováno v:
Journal of Peptide Science. 12:354-360
Human monocyte chemoattractant protein 1 (MCP-1, CCL2) is a 8.6-kDa protein that has been implicated in a number of diseases including atherosclerosis, rheumatoid arthritis, chronic obstructive pulmonary disease and cancer. As part of a program to id
Autor:
Susan H. Tam, Marian T. Nakada, Marian Kruszynski, Alexander H. Taylor, George Heavner, William E. Fieles
Publikováno v:
Archives of Biochemistry and Biophysics. 331:23-30
The sequence 36–50 from the lectin domain of human P-selectin has been previously identified as a weak inhibitor of selectin-dependent leukocyte adhesion. A series of C- and N-terminally truncated peptides was synthesized to determine the limits of
Autor:
Jil Carton, Ute Jager, George Heavner, Marian Kruszynski, Ping Tsui, Daniela Della Ducata, Anuk Das, Michael Bardroff, Jinquan Luo, Li Yan, Jennifer F. Nemeth, Nicole Stowell, Michael Brigham-Burke, Robert Rauchenberger, Raymond Sweet, Heena Beck
Publikováno v:
Understanding Biology Using Peptides ISBN: 9780387265698
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc0032297186d8e2342e8af0bfd558fb
https://doi.org/10.1007/978-0-387-26575-9_180
https://doi.org/10.1007/978-0-387-26575-9_180
Autor:
Marian Kruszynski, Jennifer F. Nemeth, Reannon Holland, George Heavner, Steven C. Pomerantz, Nicole Stowell, Tami L. Raguse, Anuk Das, Thomas Bodenstine
Publikováno v:
Understanding Biology Using Peptides ISBN: 9780387265698
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ef0e07bf13f5f826855675019301c46
https://doi.org/10.1007/978-0-387-26575-9_23
https://doi.org/10.1007/978-0-387-26575-9_23
Publikováno v:
Regulatory Peptides. 27:257-262
Thymopoietin, a polypeptide hormone of the thymus, and the synthetic pentapeptide thymopentin, corresponding to thymopoietin 32–36 , both induced elevations of intracellular cyclic GMP in two human T cell lines, CEM and MOLT-4. In contrast, the clo
Autor:
Raymond W. Sweet, Anuk Das, Nicole Stowell, Marian Kruszynski, Ping Tsui, Michael Brigham-Burke, Jonathan Seideman, Jennifer F. Nemeth, George Heavner
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 12(1)
Novel analogs of human monocyte chemoattractant protein 1 (MCP-1) were designed, synthesized and characterized to be used as tools to generate monoclonal antibodies as potential human therapeutics. MCP-1 and three analogs were synthesized by step-wis
Autor:
Robert Jordan, George Heavner, George Treacy, David M. Knight, Jill Giles-Komar, Marian Kruszynski, Tam Susan H
Publikováno v:
Platelets. 15(7)
Monoclonal antibodies have been firmly established as human therapeutics. Their high affinity and specificity for target antigens minimize adverse reactions and their molecular size results in extended circulation times relative to small molecule pha