Zobrazeno 1 - 10
of 47
pro vyhledávání: '"George Harb"'
Autor:
Ashley M. Fortress, Kiyoharu J. Miyagishima, Amberlynn A. Reed, Sally Temple, Dennis O. Clegg, Budd A. Tucker, Timothy A. Blenkinsop, George Harb, Thomas N. Greenwell, Tenneille E. Ludwig, Kapil Bharti
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract National Eye Institute recently issued a new Strategic Plan outlining priority research areas for the next 5 years. Starting cell source for deriving stem cell lines is as an area with gaps and opportunities for making progress in regenerati
Externí odkaz:
https://doaj.org/article/b5b13c2ea0074af788766f71aeeb249c
Autor:
Feryal Al-Saber, Waleed Aldosari, Mariam Alselaiti, Hesham Khalfan, Ahmed Kaladari, Ghulam Khan, George Harb, Riyadh Rehani, Sizuka Kudo, Aya Koda, Tohru Tanaka, Motowo Nakajima, Abdulla Darwish
Publikováno v:
Journal of Diabetes Research, Vol 2016 (2016)
Type 2 diabetes mellitus is prevalent especially in Gulf countries and poses serious long-term risks to patients. A multifaceted treatment approach can include nutritional supplements with antioxidant properties such as 5-aminolevulinic acid (5-ALA)
Externí odkaz:
https://doaj.org/article/5344042ef400427089bf876e7daca7f3
Autor:
Tsunehiro Kobayashi, Hossein Arefanian, George Harb, Eric B. Tredget, Ray V. Rajotte, Gregory S. Korbutt, Gina R. Rayat
Publikováno v:
Cell Transplantation, Vol 17 (2008)
Several studies have demonstrated that in vitro culture of islets prolonged islet graft survival in immune-competent mice without administration of antirejection drugs. However, we recently showed that in vitro cultured microencapsulated neonatal por
Externí odkaz:
https://doaj.org/article/ce36837084fb42b5a3e95e43d6d2356e
Autor:
Tsunehiro Kobayashi M.D., Ph.D., Yukio Aomatsu, Hiroo Iwata, Tatsuya Kin, Hiromichi Kanehiro, Michiyoshi Hisanga, Saiho Ko, Mitsuo Nagao, George Harb, Yoshiyuki Nakajima
Publikováno v:
Cell Transplantation, Vol 15 (2006)
The long-term durability of agarose microencapsulated islets against autoimmunity was evaluated in NOD mice. Islets were isolated from 6-8-week-old prediabetic male NOD mice and microencapsulated in 5% agarose hydrogel. Microencapsulated or nonencaps
Externí odkaz:
https://doaj.org/article/9ed5cefc78cc417287ff75561d0cd857
Autor:
Tingting Mo, Yefen Zou, Weijun Shen, Zhihong Huang, Xiaoyue Zhang, Qihui Jin, Jing Li, Shifeng Pan, Michael Di Donato, Loren Jon, Andrew M. Schumacher, George Harb, Shanshan Yan, Anwesh Kamireddy, You-Qing Zhang, Tom Y.-H. Wu, Yong Jia, Xueshi Hao, Yahu A. Liu, Richard Glynne, Bryan Laffitte, Brandon Taylor, Peter McNamara, Qiang Ding, Wenqi Gao, Valentina Molteni, Badry Bursalaya, Lisa Deaton, Chun Li
Publikováno v:
ChemMedChem. 15:1562-1570
Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d25eb2a68736314c37d5245dad02a1
https://doi.org/10.1002/cmdc.202000183
https://doi.org/10.1002/cmdc.202000183
Publikováno v:
Australian Journal of Teacher Education. 45:74-90
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::815cdf98540615e539108b36cb34f48b
https://doi.org/10.14221/ajte.2020v45n5.5
https://doi.org/10.14221/ajte.2020v45n5.5
Autor:
Bo Liu, Sukwon Ha, H. Michael Petrassi, Kate Jacobsen, George Harb, W. Perry Gordon, Bryan Laffitte, Thanh Lam, Qihui Jin, Yong Jia, Janine E. Baaten, Minhua Qiu, Robert Hill, Shelly Meeusen, Shanshan Yan, Badry Bursulaya, Valentina Molteni, Anwesh Kamireddy, Lisa Deaton, Jianfeng Pan, You-Qing Zhang, Loren Jon, Michael DiDonato, Yahu A. Liu, Shifeng Pan, Andrew M. Schumacher, Tingting Mo, Yefen Zou, Xiaoyue Zhang, Weijun Shen, Karyn Colman, Richard Glynne, Xueshi Hao, Peter McNamara, Vân Nguyen-Tran, Zhicheng Wang, Sheryll Espinola, Bao Nguyen, Tom Y.-H. Wu, Jing Li, Qiang Ding
Publikováno v:
Journal of Medicinal Chemistry. 63:2958-2973
Autoimmune deficiency and destruction in either β-cell mass or function can cause insufficient insulin levels and, as a result, hyperglycemia and diabetes. Thus, promoting β-cell proliferation could be one approach toward diabetes intervention. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222e5ae5085b8fd7b08c90167919a793
https://doi.org/10.1021/acs.jmedchem.9b01624
https://doi.org/10.1021/acs.jmedchem.9b01624
Autor:
Henry L. Bushnell, George Harb, Felicia W. Pagliuca, Elad Sintov, Mads Gürtler, Aubrey L. Faust, Quinn P. Peterson, Douglas A. Melton, Jennifer H. R. Kenty, Adrian Veres, Elise N. Engquist, Yeh Chuin Poh
Publikováno v:
Nature. 569:368-373
In vitro differentiation of human stem cells can produce pancreatic β-cells; the loss of this insulin-secreting cell type underlies type 1 diabetes. Here, as a step towards understanding this differentiation process, we report the transcriptional pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e64bcb41ab0bcd5d44ec18211f97c4b5
https://doi.org/10.1038/s41586-019-1168-5
https://doi.org/10.1038/s41586-019-1168-5
Publikováno v:
Current Transplantation Reports. 4:202-210
Advances in human pluripotent stem cell (hPSC) differentiation protocols have enabled cellular replacement therapies to progress to clinical trials. In patients with Type 1 diabetes (T1D), an autoimmune disease eliminates the majority of islet β cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::116fbfa4cc445736e6a3a6b7b2a7d03d
https://doi.org/10.1007/s40472-017-0161-x
https://doi.org/10.1007/s40472-017-0161-x
Publikováno v:
OBM Transplantation. 3:1-1
Single cell genomics is a powerful tool to study cellular heterogeneity and discover novel cell types. Recent studies used single cell RNA sequencing (scRNA-seq) to analyze the transcriptomes of individual pancreatic islet cells. Islets are a complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be3b15a3077271d27565b79ae9ed2c96
https://doi.org/10.21926/obm.transplant.1903072
https://doi.org/10.21926/obm.transplant.1903072