Zobrazeno 1 - 10
of 143
pro vyhledávání: '"George H. Caughey"'
Autor:
Jack Chovanec, Ilker Tunc, Jason Hughes, Joseph Halstead, Allyson Mateja, Yihui Liu, Michael P. O’Connell, Jiwon Kim, Young Hwan Park, Qinlu Wang, Quang Le, Mehdi Pirooznia, Neil N. Trivedi, Yun Bai, Yuzhi Yin, Amy P. Hsu, Joshua McElwee, Sheryce Lassiter, Celeste Nelson, Judy Bandoh, Thomas DiMaggio, Julij Šelb, Matija Rijavec, Melody C. Carter, Hirsh D. Komarow, Vito Sabato, Joshua Steinberg, Kurt M. Hafer, Elizabeth Feuille, Christopher S. Hourigan, Justin Lack, Paneez Khoury, Irina Maric, Roberta Zanotti, Patrizia Bonadonna, Lawrence B. Schwartz, Joshua D. Milner, Sarah C. Glover, Didier G. Ebo, Peter Korošec, George H. Caughey, Erica H. Brittain, Ben Busby, Dean D. Metcalfe, Jonathan J. Lyons
Publikováno v:
Blood Advances. 7:1796-1810
Serum tryptase is a biomarker used to aid in the identification of certain myeloid neoplasms, most notably systemic mastocytosis, where basal serum tryptase (BST) levels >20 ng/mL are a minor criterion for diagnosis. Although clonal myeloid neoplasms
Autor:
George H. Caughey
Publikováno v:
Immunology and Allergy Clinics of North America.
Autor:
Melody C. Carter, Sarah C. Glover, Dean D. Metcalfe, Peter Korošec, George H. Caughey, Patrizia Bonadonna, Lawrence B. Schwartz, Joshua D. Milner, Jonathan J. Lyons
Publikováno v:
Annals of Allergy, Asthma & Immunology. 127:638-647
Objective To describe our current understanding of hereditary α-tryptasemia (HαT), how HαT fits into the evolutionary context of tryptases and contemporary framework of mast cell–associated disorders, and to discuss the future clinical and thera
Autor:
Jack Chovanec, Ilker Tunc, Jason Hughes, Joseph Halstead, Allyson Mateja, Yihui Liu, Michael P. O’Connell, Jiwon Kim, Young Hwan Park, Qinlu Wang, Quang Le, Mehdi Pirooznia, Neil N. Trivedi, Yun Bai, Yuzhi Yin, Amy P. Hsu, Josh McElwee, Sheryce Lassiter, Celeste Nelson, Judy Bandoh, Thomas DiMaggio, Julij Šelb, Matija Rijavec, Melody C. Carter, Hirsh D. Komarow, Vito Sabato, Joshua Steinberg, Kurt M. Hafer, Elizabeth Feuille, Christopher S. Hourigan, Justin Lack, Paneez Khoury, Irina Maric, Roberta Zanotti, Patrizia Bonadonna, Lawrence B. Schwartz, Joshua D. Milner, Sarah C. Glover, Didier G. Ebo, Peter Korošec, George H. Caughey, Erica H. Brittain., Ben Busby, Dean D. Metcalfe, Jonathan J. Lyons
Publikováno v:
Blood advances
Serum tryptase is a biomarker used to aid in the identification of certain myeloid neoplasms, most notably systemic mastocytosis, where baseline (BST) levels >20 ng/mL are a minor criterion for diagnosis. Whereas clonal myeloid neoplasms are rare, th
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164501 (2016)
Host-derived proteases can augment or help to clear infections. This dichotomy is exemplified by cathepsin L (CTSL), which helps Hendra virus and SARS coronavirus to invade cells, but is essential for survival in mice with mycoplasma pneumonia. The p
Externí odkaz:
https://doaj.org/article/a443385108de4852baad623a323f6e17
Autor:
Oishee Bose, Peter Baluk, Mark R Looney, Laurence E Cheng, Donald M McDonald, George H Caughey, Matthew F Krummel
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118513 (2015)
Mast cells (MC) and myeloid dendritic cells (DC) act proximally in detecting and processing antigens and immune insults. We sought to understand their comparative dynamic behavior with respect to the airway epithelium in the steady state and in respo
Externí odkaz:
https://doaj.org/article/545eb36b385f4e53a32cfedd666a1d9c
Regulation of hepatocyte growth factor in mice with pneumonia by peptidases and trans-alveolar flux.
Autor:
Wilfred W Raymond, Xiang Xu, Shilpa Nimishakavi, Catherine Le, Donald M McDonald, George H Caughey
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125797 (2015)
Hepatocyte growth factor (HGF) promotes lung epithelial repair after injury. Because prior studies established that human neutrophil proteases inactivate HGF in vitro, we predicted that HGF levels decrease in lungs infiltrated with neutrophils and th
Externí odkaz:
https://doaj.org/article/bba865b35aa94377a60749efa5a7c654
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141169 (2015)
Tryptic serine proteases of bronchial epithelium regulate ion flux, barrier integrity, and allergic inflammation. Inhibition of some of these proteases is a strategy to improve mucociliary function in cystic fibrosis and asthmatic inflammation. Sever
Externí odkaz:
https://doaj.org/article/b88659b513e64bf6880afc0a97be084c
Autor:
Kelly M. Loyet, Neil N. Trivedi, Racquel Corpuz, Brian L. Yaspan, Tracy Staton, Henry R. Maun, Erin H. Christensen, Kathila R. Alatsis, Xiumin Wu, Michael T. Lipari, Yvonne Franke, Mark S. Dennis, Daniel Kirchhofer, Wyne P. Lee, Rahul Ahuja, Xiaocheng Chen, Ashley Morando, Diana Chang, James T. Koerber, Aija Kusi, Joseph R. Arron, John Liu, Guiquan Jia, Juan Zhang, Janet Jackman, Ping Wu, George H. Caughey, Yan Wu, Rajesh Vij, Luz D. Orozco, Lawrence B. Schwartz, Benjamin T. Walters, Charles Eigenbrot, Prescott G. Woodruff, Lawren C. Wu, David F. Choy, Robert A. Lazarus, Meire Bremer, Amy Dressen, Magda Babina, Tangsheng Yi, Savita Ubhayakar, Xiaorong Liang, Jeff Lutman, Siddharth Sukumaran, Jason A. Hackney, John V. Fahy, Julie Q. Hang, Cary D. Austin, Manda Wong
Publikováno v:
Cell, vol 179, iss 2
Cell
Cell
Severe asthma patients with low type 2 inflammation derive less clinical benefit from therapies targeting type 2 cytokines and have significant unmet medical needs. We show that mast cell tryptase is elevated in severe asthma patients, correlating wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c0946c02d2066eb05676694e454e0e
https://escholarship.org/uc/item/8pf5p52n
https://escholarship.org/uc/item/8pf5p52n
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27564 (2011)
Mammals are serially infected with a variety of microorganisms, including bacteria and parasites. Each infection reprograms the immune system's responses to re-exposure and potentially alters responses to first-time infection by different microorgani
Externí odkaz:
https://doaj.org/article/6529f34e57034673a0907a340c66d092