Zobrazeno 1 - 10
of 28
pro vyhledávání: '"George H. Searfoss"'
Publikováno v:
Toxicological Sciences. 167:202-210
The discovery of mammalian cardiac progenitor cells has suggested that the heart consists of not only terminally differentiated beating cardiomyocytes, but also a population of self-renewing stem cells with the potential to generate new cardiomyocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35f9f7a1aa052b04674dcadfaaf8a20
https://doi.org/10.1093/toxsci/kfy229
https://doi.org/10.1093/toxsci/kfy229
Autor:
Jiangang Liu, Robert A Jolly, Aaron T Smith, George H Searfoss, Keith M Goldstein, Vladimir N Uversky, Keith Dunker, Shuyu Li, Craig E Thomas, Tao Wei
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24233 (2011)
Toxicogenomics promises to aid in predicting adverse effects, understanding the mechanisms of drug action or toxicity, and uncovering unexpected or secondary pharmacology. However, modeling adverse effects using high dimensional and high noise genomi
Externí odkaz:
https://doaj.org/article/460262842e27456d831ce9d442c35aed
Autor:
Jeffrey A. Willy, D G Hall, Keith M. Goldstein, Yue Webster, Jeffrey J. Sutherland, A R Irizarry, James L. Stevens, George H. Searfoss
Publikováno v:
The Pharmacogenomics Journal. 18:377-390
Despite investment in toxicogenomics, nonclinical safety studies are still used to predict clinical liabilities for new drug candidates. Network-based approaches for genomic analysis help overcome challenges with whole-genome transcriptional profilin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e673cbb588b76af7e612ed4474389b
https://doi.org/10.1038/tpj.2017.17
https://doi.org/10.1038/tpj.2017.17
Autor:
Jeffrey A. Willy, Thomas K. Baker, George H. Searfoss, Brianna M Paisley, Bartley W. Halstead, Steven K. Engle
Publikováno v:
Translating Molecules into Medicines ISBN: 9783319500409
Early safety assessment efforts from target identification to lead development have undergone rapid growth and evolution over the last 10 years. In this chapter, we will discuss the current development trends driving the need for early safety assessm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db81cb399fbb81e8cb881fc9cd8859e6
https://doi.org/10.1007/978-3-319-50042-3_5
https://doi.org/10.1007/978-3-319-50042-3_5
Publikováno v:
ILAR journal. 57(2)
Cardiovascular (CV) safety liabilities are significant concerns for drug developers and preclinical animal studies are predominately where those liabilities are characterized before patient exposures. Steady progress in technology and laboratory capa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be741be61060e8cc419099ee013116b9
https://pubmed.ncbi.nlm.nih.gov/28053066
https://pubmed.ncbi.nlm.nih.gov/28053066
Autor:
Alok K. Sharma, Paul W. Snyder, William H. Jordan, Rachel Y. Reams, Timothy P. Ryan, Alan Y. Chiang, George H. Searfoss, Robert A. Jolly
Publikováno v:
Toxicologic Pathology. 37:776-789
Mesial temporal lobe epilepsy (MTLE) is a severe neurological condition of unknown pathogenesis for which several animal models have been developed. To obtain a better understanding of the underlying molecular mechanisms and identify potential biomar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602cb7780eafcd33a6eb6a3166bc0f62
https://doi.org/10.1177/0192623309344202
https://doi.org/10.1177/0192623309344202
Publikováno v:
Toxicologic Pathology. 36:190-203
Homozygous p53 deficient knockout mice were used to assess the role of p53 in tumor promotion by the protein phosphatase inhibitor and hepatic tumor promoter microcystin-LR (MCLR). More than 50% of human cancers bear mutations in the p53 gene, and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c380d6446673a1368419d181a3378c7d
https://doi.org/10.1177/0192623307311406
https://doi.org/10.1177/0192623307311406
Autor:
Melanie Huffman, Armando R. Irizarry, Adam West, George H. Searfoss, Hui-Rong Qian, Shuyu Li, James L. Stevens, Hong Gao, John P. Stutz, Bartley W. Halstead, Thomas K. Baker, Robert A. Jolly, Yin Guo, John N. Calley, Timothy P. Ryan
Publikováno v:
Toxicological Sciences. 96:294-309
Marked species-specific responses to agonists of the peroxisome proliferator-activated alpha receptor (PPAR alpha) have been observed in rats and dogs, two species typically used to assess the potential human risk of pharmaceuticals in development. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34241083590d5d8c3dc5d6103f7c4bb3
https://doi.org/10.1093/toxsci/kfm009
https://doi.org/10.1093/toxsci/kfm009
Autor:
David O. Calligaro, Marnie A. Higgins, Linda M. Schirtzinger, Timothy P. Ryan, Hong Gao, Elizabeth Galbreath, George H. Searfoss, Patrick C. May, Brian R. Berridge, William H. Jordan
Publikováno v:
Journal of Biological Chemistry. 278:46107-46116
Functional gamma-secretase inhibitors (FGSIs) can block the cleavage of several transmembrane proteins including amyloid precursor protein (APP), and the cell fate regulator Notch-1. FGSIs, by inhibiting APP processing, block the generation of amyloi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7791b07ee5e6c1da0cd8fb889cf4ff
https://doi.org/10.1074/jbc.m307757200
https://doi.org/10.1074/jbc.m307757200
Autor:
Marnie A. Higgins, B. J. Mills, Thomas K. Baker, B. R. Berridge, Hong Gao, Timothy P. Ryan, George H. Searfoss, A. E. Schultze
Publikováno v:
Toxicological Sciences. 74:470-484
The safety of pharmaceuticals is typically assessed in the dog and rat prior to investigation in humans. As a result, a greater understanding of adverse effects in these preclinical testing species would improve safety assessment. Despite this need,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b99e26ed9f80e3c509c690d4f4e1024
https://doi.org/10.1093/toxsci/kfg142
https://doi.org/10.1093/toxsci/kfg142