Zobrazeno 1 - 10
of 44
pro vyhledávání: '"George G. Schweitzer"'
Autor:
George G. Schweitzer, Grace L. Ditzenberger, Curtis C. Hughey, Brian N. Finck, Michael R. Martino, Christina A. Pacak, Barry J. Byrne, William Todd Cade
Publikováno v:
PLoS ONE, Vol 18, Iss 8 (2023)
Barth syndrome (BTHS) is an X-linked recessive genetic disorder due to mutations in the Tafazzin (TAFAZZIN) gene that lead to cardiac and skeletal muscle mitochondrial dysfunction. Previous studies in humans with BTHS demonstrate that the defects in
Externí odkaz:
https://doaj.org/article/48127967996a463a8828fde44dba47e6
Autor:
Kari T. Chambers, Michael A. Cooper, Alison R. Swearingen, Rita T. Brookheart, George G. Schweitzer, Carla J. Weinheimer, Attila Kovacs, Timothy R. Koves, Deborah M. Muoio, Kyle S. McCommis, Brian N. Finck
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Lipin 1 is a bifunctional protein that is a transcriptional regulator and has phosphatidic acid (PA) phosphohydrolase activity, which dephosphorylates PA to generate diacylglycerol. Human lipin 1 mutations lead to episodic rhabdomyolysis, and some af
Externí odkaz:
https://doaj.org/article/4e406f9b70c944e9aad9c1f34b024475
Autor:
Andrew J. Lutkewitte, Kyle S. McCommis, George G. Schweitzer, Kari T. Chambers, Mark J. Graham, Lingjue Wang, Gary J. Patti, Angela M. Hall, Brian N. Finck
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 528-538 (2019)
During prolonged fasting, the liver plays a central role in maintaining systemic energy homeostasis by producing glucose and ketones in processes fueled by oxidation of fatty acids liberated from adipose tissue. In mice, this is accompanied by transi
Externí odkaz:
https://doaj.org/article/182766521768470a976245b2e220742c
Autor:
George G. Schweitzer, Connie Gan, Robert C. Bucelli, Daniel Wegner, Robert E. Schmidt, Marwan Shinawi, Brian N. Finck, Rita T. Brookheart
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 7, Iss 7, Pp n/a-n/a (2019)
Abstract Background Site‐1 Protease (S1P) is a Golgi‐resident protein required for the activation of regulatory proteins that drive key cellular functions, including, the unfolded protein response (UPR) and lipid and cholesterol biosynthesis. Whi
Externí odkaz:
https://doaj.org/article/12edbc206f564b2d841a94ae674d4b9f
Autor:
George G. Schweitzer, Zhouji Chen, Connie Gan, Kyle S. McCommis, Nisreen Soufi, Roman Chrast, Mayurranjan S. Mitra, Kui Yang, Richard W. Gross, Brian N. Finck
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 4, Pp 848-858 (2015)
Lipin proteins (lipin 1, 2, and 3) regulate glycerolipid homeostasis by acting as phosphatidic acid phosphohydrolase (PAP) enzymes in the TG synthesis pathway and by regulating DNA-bound transcription factors to control gene transcription. Hepatic PA
Externí odkaz:
https://doaj.org/article/2459d724c88541a18ee0c839a3ff7076
Autor:
Patrick A. Vigueira, Kyle S. McCommis, George G. Schweitzer, Maria S. Remedi, Kari T. Chambers, Xiaorong Fu, William G. McDonald, Serena L. Cole, Jerry R. Colca, Rolf F. Kletzien, Shawn C. Burgess, Brian N. Finck
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 2042-2053 (2014)
Carrier-facilitated pyruvate transport across the inner mitochondrial membrane plays an essential role in anabolic and catabolic intermediary metabolism. Mitochondrial pyruvate carrier 2 (Mpc2) is believed to be a component of the complex that facili
Externí odkaz:
https://doaj.org/article/0d9bb6c80ceb445b921d7c646f9c7d02
Publikováno v:
Journal of the Endocrine Society. 7
Context The Pritikin Program, which provides intensive lifestyle therapy, has been shown to improve cardiometabolic outcomes when provided as a residential program. Objective The purpose of the present study was to conduct a short-term, randomized, c
Publikováno v:
Int J Obes (Lond)
BACKGROUND AND OBJECTIVES: Although obesity is typically associated with metabolic co-morbidities, some people with obesity do not develop metabolic abnormalities. We evaluated whether modifiable lifestyle factors (i.e., physical activity, dietary co
Autor:
Marc K. Hellerstein, Maria Chondronikola, Mahalakshmi Shankaran, Adewole L. Okunade, Bruce W. Patterson, Gordon I. Smith, Edna Nyangau, Tyler Field, Samuel Klein, Mihoko Yoshino, Joseph W. Beals, Saswata Talukdar, Claude B. Sirlin, George G. Schweitzer
Publikováno v:
The Journal of clinical investigation, vol 130, iss 3
J Clin Invest
J Clin Invest
BACKGROUND: An increase in intrahepatic triglyceride (IHTG) is the hallmark feature of nonalcoholic fatty liver disease (NAFLD) and is decreased by weight loss. Hepatic de novo lipogenesis (DNL) contributes to steatosis in individuals with NAFLD. The
Autor:
George G. Schweitzer, Carla J. Weinheimer, Rita T. Brookheart, Kari T. Chambers, Alison R. Swearingen, Kyle S. McCommis, Timothy R. Koves, Michael A. Cooper, Attila Kovacs, Brian N. Finck, Deborah M. Muoio
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 9 (2021)
JCI Insight, Vol 6, Iss 9 (2021)
Lipin 1 is a bifunctional protein that is a transcriptional regulator and has phosphatidic acid (PA) phosphohydrolase activity, which dephosphorylates PA to generate diacylglycerol. Human lipin 1 mutations lead to episodic rhabdomyolysis, and some af