Zobrazeno 1 - 10
of 30
pro vyhledávání: '"George G. Dougherty"'
Autor:
Jeffrey K Yao, George G Dougherty, Ravinder D Reddy, Wayne R Matson, Rima eKaddurah-Daouk, Matcheri S Keshavan
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 7 (2013)
Schizophrenia (SZ) is a biochemically complex disorder characterized by widespread defects in multiple metabolic pathways whose dynamic interactions, until recently, have been difficult to examine. Rather, evidence for these alterations has been coll
Externí odkaz:
https://doaj.org/article/f71ec5f983d94734a0eeb9b964f0c0fa
Autor:
Joseph McEvoy, Rebecca A Baillie, Hongjie Zhu, Peter Buckley, Matcheri S Keshavan, Henry A Nasrallah, George G Dougherty, Jeffrey K Yao, Rima Kaddurah-Daouk
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68717 (2013)
There is a critical need for mapping early metabolic changes in schizophrenia to capture failures in regulation of biochemical pathways and networks. This information could provide valuable insights about disease mechanisms, trajectory of disease pro
Externí odkaz:
https://doaj.org/article/2be2a32226b64501ba4c7ca698675037
Autor:
Jeffrey K Yao, Ruth Condray, George G Dougherty, Matcheri S Keshavan, Debra M Montrose, Wayne R Matson, Joseph McEvoy, Rima Kaddurah-Daouk, Ravinder D Reddy
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42165 (2012)
The antioxidant defense system, which is known to be dysregulated in schizophrenia, is closely linked to the dynamics of purine pathway. Thus, alterations in the homeostatic balance in the purine pathway may be involved in the pathophysiology of schi
Externí odkaz:
https://doaj.org/article/3e57518040c74256a0f38ac9b7470f1a
Comparison of transitional vs surgical menopause on monoamine and amino acid levels in the rat brain
Autor:
Robert B. Gibbs, Ziv Z. Kirshner, Jeffrey K. Yao, Junyi Li, Tao Long, George G. Dougherty, D. Nelson
Publikováno v:
Molecular and Cellular Endocrinology. 476:139-147
Loss of ovarian function has important effects on neurotransmitter production and release with corresponding effects on cognitive performance. To date, there has been little direct comparison of the effects of surgical and transitional menopause on n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d7fa5686523e58055b572539ed8d73
https://doi.org/10.1016/j.mce.2018.05.003
https://doi.org/10.1016/j.mce.2018.05.003
Autor:
Ravinder Reddy, Matcheri S. Keshavan, Debra M. Montrose, George G. Dougherty, Xiang Zhou, Gretchen L. Haas, HuaLin Cai, Jeffrey K. Yao
Publikováno v:
Psychoneuroendocrinology. 90:43-51
Neurosteroids are both endogenous and exogenous steroids that rapidly alter neuronal excitability through interactions with ligand-gated ion channels and other cell surface receptors. They are originated from cholesterol and have important implicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8631be28e762a2a54d668e545e1f3690
https://doi.org/10.1016/j.psyneuen.2018.02.004
https://doi.org/10.1016/j.psyneuen.2018.02.004
Autor:
Jeffrey K Yao, George G Dougherty, Ravinder D Reddy, Matcheri S Keshavan, Debra M Montrose, Wayne R Matson, Joseph McEvoy, Rima Kaddurah-Daouk
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9508 (2010)
BackgroundPurine catabolism may be an unappreciated, but important component of the homeostatic response of mitochondria to oxidant stress. Accumulating evidence suggests a pivotal role of oxidative stress in schizophrenia pathology.Methodology/princ
Externí odkaz:
https://doaj.org/article/9fd702232d2d441fa6a9c0c0d281c59f
Autor:
John A. Gurklis, Erik Messamore, Gretchen L. Haas, Ruth Condray, Clara H. Gautier, George G. Dougherty, Jeffrey K. Yao, John Kasckow, Benjamin L. Kisslinger
Publikováno v:
Schizophrenia Bulletin
The skin flush response to niacin is abnormally blunted among a subset of patients with schizophrenia (SZ), preferentially associates with SZ compared to other mental illnesses, occurs frequently in nonpsychotic members of SZ-affected families, appea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7627f8b8f1c1141c2d9aa9c01f2c8a65
https://doi.org/10.1093/schbul/sbv130
https://doi.org/10.1093/schbul/sbv130
Autor:
Junyi Li, George G. Dougherty, Robert B. Gibbs, D. Nelson, Jeffrey K. Yao, Tao Long, Ziv Z. Kirshner
Publikováno v:
Mol Cell Endocrinol
Estrogens have many beneficial effects in the brain. Previously, we evaluated the effects of two models of menopause (surgical vs. transitional) on multiple monoaminergic endpoints in different regions of the adult rat brain in comparison with levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa5c18144737683d73ff2ab2942f674
https://doi.org/10.1016/j.mce.2019.110533
https://doi.org/10.1016/j.mce.2019.110533
Autor:
A Sonel, E Sonel, KN Chengappa, Matcheri S. Keshavan, S Magan, John A. Gurklis, Ravinder Reddy, George G. Dougherty, B Kisslinger, J.K. Yao
Publikováno v:
Schizophrenia Bulletin. 43:S162-S163
Background: There is excess and premature mortality in schizophrenia (SZ), from both natural and unnatural causes, when compared to the general population. In a 15-year follow-up study of SZ patients, 22% had died, of which greater than 50% died from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c7dbb829950d96a97250e0120257f0
https://doi.org/10.1093/schbul/sbx024.005
https://doi.org/10.1093/schbul/sbx024.005
Autor:
Steven D. Forman, Charlene Wick-Hull, V. Andrew Stenger, B. J. Casey, Liubomir A. Pisarov, Emily Lorensen, George G Dougherty, Greg J. Siegle, Todd S. Braver, M Deanna
Publikováno v:
Biological Psychiatry. 55:531-537
Background Healthy individuals performing response suppression tasks activate anterior cingulate cortex with occurrence of false alarm error responses to nontargets. Fundamental questions include whether this error-related activation provides a signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d02d5e960763cbce8d2d08e2de77b0a
https://doi.org/10.1016/j.biopsych.2003.09.011
https://doi.org/10.1016/j.biopsych.2003.09.011