Zobrazeno 1 - 10
of 159
pro vyhledávání: '"George G Holz"'
Autor:
Marie-Line Peyot, Joshua P Gray, Julien Lamontagne, Peter J S Smith, George G Holz, S R Murthy Madiraju, Marc Prentki, Emma Heart
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6221 (2009)
BACKGROUND:Glucagon like peptide-1 (GLP-1) and its analogue exendin-4 (Ex-4) enhance glucose stimulated insulin secretion (GSIS) and activate various signaling pathways in pancreatic beta-cells, in particular cAMP, Ca(2+) and protein kinase-B (PKB/Ak
Externí odkaz:
https://doaj.org/article/7d396a0b850a4ad5aa357832404999c2
Autor:
Christos Markatos, Georgia Biniari, Oleg G. Chepurny, Vlasios Karageorgos, Nikos Tsakalakis, Georgios Komontachakis, Zacharenia Vlata, Maria Venihaki, George G. Holz, Theodore Tselios, George Liapakis
Publikováno v:
Molecules, Vol 29, Iss 17, p 4127 (2024)
The gonadotropin-releasing hormone (GnRH) receptor (GnRH-R) is highly expressed in ovarian cancer cells (OCC), and it is an important molecular target for cancer therapeutics. To develop a new class of drugs targeting OCC, we designed and synthesized
Externí odkaz:
https://doaj.org/article/629b6733c8b64a05a82d4be18e501779
Autor:
Kylie S. Chichura, Clinton T. Elfers, Therese S. Salameh, Varun Kamat, Oleg G. Chepurny, Aelish McGivney, Brandon T. Milliken, George G. Holz, Sarah V. Applebey, Matthew R. Hayes, Ian R. Sweet, Christian L. Roth, Robert P. Doyle
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Mechanisms underlying long-term sustained weight loss and glycemic normalization after obesity surgery include changes in gut hormone levels, including glucagon-like peptide 1 (GLP-1) and peptide YY (PYY). We demonstrate that two peptide bia
Externí odkaz:
https://doaj.org/article/dc106d853e6f471fa38cee689f96ea30
Autor:
Qinghe Meng, Xinghan Tian, Junwei Li, Napat Pruekprasert, Ravi Dhawan, George G. Holz, Robert N. Cooney
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Diabetic nephropathy (DN) is a serious complicating factor in human type 2 diabetes mellitus (T2DM), and it commonly results in end-stage renal disease (ESRD) that requires kidney dialysis. Here, we report that the α7 nicotinic acetylcholin
Externí odkaz:
https://doaj.org/article/987c01b7582a4d63a37cce4c2b02a8fd
Autor:
Berthold A. Nock, Panagiotis Kanellopoulos, Oleg G. Chepurny, Maritina Rouchota, George Loudos, George G. Holz, Eric P. Krenning, Theodosia Maina
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 666 (2022)
(1) Background: Theranostic approaches in the management of cholecystokinin subtype 2 receptor (CCK2R)-positive tumors include radiolabeled gastrin and CCK motifs. Moving toward antagonist-based CCK2R-radioligands instead, we herein present three ana
Externí odkaz:
https://doaj.org/article/9bb4110d507544979abac844cdacdd51
Autor:
Qinghe Meng, Oleg G. Chepurny, Colin A. Leech, Napat Pruekprasert, Megan E. Molnar, James Jason Collier, Robert N. Cooney, George G. Holz
Publikováno v:
Diabetes Obes Metab
AIM: α7nAChR agonist GTS-21 is potentially a new treatment for type 2 diabetes (T2D) owing to its ability to stimulate GLP-1 secretion. This study sought to establish if GTS-21 exerts a blood glucose-lowering action in db/db mice, and to test if thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688e59c554c6461193dab83539cbaefa
https://doi.org/10.1111/dom.14693
https://doi.org/10.1111/dom.14693
Autor:
Kylie S. Chichura, Clinton T. Elfers, Therese Salameh, Varun Kamat, Oleg G. Chepurny, Aelish McGivney, Brandon T. Milliken, George G. Holz, Sarah V. Applebey, Matthew R. Hayes, Ian R. Sweet, Christian L. Roth, Robert P. Doyle
SUMMARYMechanisms underlying long-term sustained weight loss and glycemic normalization after obesity surgery include changes in gut hormone levels, including glucagon-like peptide 1 (GLP-1) and peptide YY (PYY). We demonstrate that two peptide biase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4a1edc9bb65350578efbaeb4a774647
https://doi.org/10.1101/2022.11.07.515458
https://doi.org/10.1101/2022.11.07.515458
Autor:
George G. Holz, Sarah A. Doebley, Ian R. Sweet, Varun Kamat, Tito Borner, Robert P. Doyle, MacKenzie L. Swanson, Matthew R. Hayes, Bart C. De Jonghe, Ian C. Tinsley, Oleg G. Chepurny
Publikováno v:
Journal of Medicinal Chemistry
Corrination is the conjugation of a corrin ring containing molecule, such as vitamin B12 (B12) or B12 biosynthetic precursor dicyanocobinamide (Cbi), to small molecules, peptides, or proteins with the goal of modifying pharmacology. Recently, a corri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b061aa87a91447a8aee1a09b2bc098ec
http://europepmc.org/articles/PMC8279408
http://europepmc.org/articles/PMC8279408
Autor:
Christian L. Roth, Oleg G. Chepurny, Bart C. De Jonghe, George G. Holz, Clinton Elfers, Kylie S. Chichura, Matthew R. Hayes, Tito Borner, Robert P. Doyle, Ian R. Sweet, Brandon T. Milliken
Publikováno v:
J Med Chem
There is a critical unmet need for therapeutics to treat the epidemic of comorbidities associated with obesity and type 2 diabetes, ideally devoid of nausea/emesis. This study developed monomeric peptide agonists of glucagon-like peptide 1 receptor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f87628e79fa1735fd176ff82760e989
https://doi.org/10.1021/acs.jmedchem.0c01783
https://doi.org/10.1021/acs.jmedchem.0c01783
Autor:
null Qinghe Meng, null Oleg G. Chepurny, null Colin A. Leech, null Napat Pruekprasert, null Megan E. Molnar, null J. Jason Collier, null Robert N. Cooney, null George G. Holz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc374670632cc0491b0ffcc9dbd981b8
https://doi.org/10.1111/dom.14693/v2/response1
https://doi.org/10.1111/dom.14693/v2/response1