Zobrazeno 1 - 10
of 264
pro vyhledávání: '"George F. Vande Woude"'
Autor:
Jianqun Kou, Phillip R. Musich, Ben Staal, Liang Kang, Yuan Qin, Zhi Q. Yao, Boheng Zhang, Weizhong Wu, Angela Tam, Alan Huang, Huai-Xiang Hao, George F. Vande Woude, Qian Xie
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-13 (2018)
Abstract Background Aberrant MET tyrosine kinase signaling is known to cause cancer initiation and progression. While MET inhibitors are in clinical trials against several cancer types, the clinical efficacies are controversial and the molecular mech
Externí odkaz:
https://doaj.org/article/e7bf11f0134e423c8693699756a8d3d7
Autor:
Sharon Moshitch-Moshkovitz, Galia Tsarfaty, Dafna W. Kaufman, Gideon Y. Stein, Keren Shichrur, Eddy Solomon, Robert H. Sigler, James H. Resau, George F. Vande Woude, Ilan Tsarfaty
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 5, Pp 353-363 (2006)
The tyrosine kinase receptor Met and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), play an important role in normal developmental processes, as well as in tumorigenicity and metastasis. We constructed a green fluorescent protein (GFP)
Externí odkaz:
https://doaj.org/article/6655673b43f14144aa7c6b9debe68288
Autor:
Galia Tsarfaty, Gideon Y. Stein, Sharon Moshitch-Moshkovitz, Dafna W. Kaufman, Brain Cao, James H. Resau, George F. Vande Woude, Ilan Tsarfaty
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 5, Pp 344-352 (2006)
Molecular functional and metabolic imaging allows visualization of disease-causing processes in living organisms. Here we present a new approach for the functional molecular imaging (FMI) of endogenous tyrosine kinase receptor activity using Met and
Externí odkaz:
https://doaj.org/article/e47e6da363004ed093316bc497208227
Autor:
Rick V. Hay, Brian Cao, R. Scot Skinner, Ling-Mei Wang, Yanli Su, James H. Resau, George F. Vande Woude, Milton D. Gross
Publikováno v:
Molecular Imaging, Vol 1 (2002)
Inappropriate expression of the c-met-protooncogene product (Met) and/or of its ligand, hepatocyte growth factor/scatter factor (HGF/SF), has been correlated with poor prognosis in a variety of human solid tumors. We are developing animal models for
Externí odkaz:
https://doaj.org/article/c7648bca380a4e5e9b018faa4df7ab6d
Autor:
Ana M. Gonzalez-Angulo, Debu Tripathy, Gordon B. Mills, Naoto T. Ueno, John Mendelsohn, George F. Vande Woude, Kim-Anh Do, Tina Primeau, Napa Parinyanitikul, Joohyuk Sohn, Huiqin Chen, Mihai Gagea, Wenbin Liu, Bailiang Wang, Shunqiang Li, Shuying Liu
Establish MCF-10A derived cells expression of PIK3CA/MET genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0911e05296415c5fb4cc0da8bec5c486
https://doi.org/10.1158/1535-7163.22510369
https://doi.org/10.1158/1535-7163.22510369
Autor:
Ana M. Gonzalez-Angulo, Debu Tripathy, Gordon B. Mills, Naoto T. Ueno, John Mendelsohn, George F. Vande Woude, Kim-Anh Do, Tina Primeau, Napa Parinyanitikul, Joohyuk Sohn, Huiqin Chen, Mihai Gagea, Wenbin Liu, Bailiang Wang, Shunqiang Li, Shuying Liu
There is compelling evidence that oncogenic MET and PIK3CA signaling pathways contribute to breast cancer. However, the activity of pharmacologic targeting of either pathway is modest. Mechanisms of resistance to these monotherapies have not been cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1878d1b5d779580c0f2a13b1a25e1813
https://doi.org/10.1158/1535-7163.c.6539590.v1
https://doi.org/10.1158/1535-7163.c.6539590.v1
Autor:
Ana M. Gonzalez-Angulo, Debu Tripathy, Gordon B. Mills, Naoto T. Ueno, John Mendelsohn, George F. Vande Woude, Kim-Anh Do, Tina Primeau, Napa Parinyanitikul, Joohyuk Sohn, Huiqin Chen, Mihai Gagea, Wenbin Liu, Bailiang Wang, Shunqiang Li, Shuying Liu
Antibody list
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ea8f421d9c578ff6a5f5c8d8470fd9
https://doi.org/10.1158/1535-7163.22510354
https://doi.org/10.1158/1535-7163.22510354
Autor:
Carrie R. Graveel, George F. Vande Woude, Marianne K. Melnik, Jane E. Pettinga, Jayne E. Paulson, Leon D. Oostendorp, Colleen A. App, Bree D. Berghuis, Erik S. Linklater, Amanda K. Paulson
Breast cancer displays significant intratumoral heterogeneity, which has been shown to have a substantial impact on both innate and acquired resistance to tyrosine kinase inhibitors. The heterogeneous expression of multiple receptor tyrosine kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed6e182925365d03a02914afa5a2e7f
https://doi.org/10.1158/1541-7786.c.6539575
https://doi.org/10.1158/1541-7786.c.6539575
Supplementary Figures S1-S9 - PDF file 588K, Supplementary Figure S1: The chemical structures of SGX523 and erlotinib; Supplementary Figure S2: The effect of erlotinib on basal tyrosine phosphorylation of EGFR; Supplementary Figure S3: Inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f68f85d15f266edd5be15edeaa3b348
https://doi.org/10.1158/1535-7163.22500136.v1
https://doi.org/10.1158/1535-7163.22500136.v1
Autor:
Carrie R. Graveel, George F. Vande Woude, Marianne K. Melnik, Jane E. Pettinga, Jayne E. Paulson, Leon D. Oostendorp, Colleen A. App, Bree D. Berghuis, Erik S. Linklater, Amanda K. Paulson
PDF - 39K, The ER, PR, and HER2 (ERBB2) status was determined by standardized immunohistochemical staining and pathological analysis at Spectrum Health. ER, PR, and HER2 scores are based on IHC guidelines recommended by the ASCO/CAP.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012d06ebd6d3bd81dcf86a726ae1ad8f
https://doi.org/10.1158/1541-7786.22510324
https://doi.org/10.1158/1541-7786.22510324