Zobrazeno 1 - 8
of 8
pro vyhledávání: '"George F. Njoroge"'
Autor:
Ernest Asante-Appiah, Sony Agrawal, Peter T. Meinke, Ellen Xia, Anilkumar G. Nair, Joseph A. Kozlowski, Lei Chen, De-Yi Yang, Michael P. Dwyer, Craig A. Coburn, Oleg Selyutin, Michael Wong, Rong Kong, Bin Hu, George F Njoroge, Amin A. Nomeir, Tao Ji, Rong Liu, Paul Ingravallo, Ling Tong, Ying Zhai, Stuart B. Rosenblum, Yueheng Jiang, Wensheng Yu, James I. Fells, Bin Zhong, Kevin X. Chen, Qingbei Zeng
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(13)
HCV NS5A inhibitors have demonstrated impressive in vitro potency profiles in HCV replicon assays and robust HCV RNA titer reduction in the clinic making them attractive components for inclusion in an all oral fixed dose combination regimen for the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7b1449a073e396c15e702031383c2f
https://pubmed.ncbi.nlm.nih.gov/27180013
https://pubmed.ncbi.nlm.nih.gov/27180013
Autor:
Alan Hruza, Doll Ronald J, Corey Strickland, George F. Njoroge, Viyyoor M. Girijavallabhan, Paul Kirschmeier, Hugh Y. Zhu, Alan B. Cooper, W. Robert Bishop, Jagdish A. Desai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1134-1136
The discovery of C-linked imidazole azaheptapyridine bridgehead FPT inhibitors is described. This novel class of compounds are sub nM FPT enzyme inhibitors with potent cellular inhibitory activities. This series also has reduced hERG activity versus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d2b987196690cb380652f00f14b7a5
https://doi.org/10.1016/j.bmcl.2009.12.013
https://doi.org/10.1016/j.bmcl.2009.12.013
Autor:
Birendra N. Pramanik, Tin-Yau Chan, Bruce Albert Malcolm, Lata Ramanathan, Yan-Hui Liu, George F Njoroge
Publikováno v:
Journal of mass spectrometry : JMS. 46(8)
An affinity-selection study using size exclusion chromatography (SEC) combined with off-line electrospray ionization mass spectrometry (ESI-MS) was performed on libraries of peptidic α-ketoamide inhibitors directed against the hepatitis C virus (HCV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad95b829f3fcbd20787b2c485c124d7
https://pubmed.ncbi.nlm.nih.gov/21766396
https://pubmed.ncbi.nlm.nih.gov/21766396
Publikováno v:
The Journal of pharmacy and pharmacology. 63(7)
Objectives Hepatitis C virus (HCV) infection represents a major worldwide-health problem. The current standard of care is combination therapy with pegylated interferon and ribavirin, which achieves a successful response in only approximately 40% of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5a4ee99ec2151d947111a9a96a794c
https://pubmed.ncbi.nlm.nih.gov/21635253
https://pubmed.ncbi.nlm.nih.gov/21635253
I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles
Autor:
Neng Yang Shih, Hsueh-Cheng Huang, Jose S. Duca, Bancha Vibulbhan, Frank Bennett, Kevin X. Chen, Stephen Gavalas, Yueheng Jiang, Robert E. Palermo, Charles A. Lesburg, Srikanth Venkatraman, Zhiqing He, Francisco Velazquez, Nancy Butkiewicz, Li Wang, Boris Feld, Pinto Patrick A, Gopinadhan N. Anilkumar, Yuhua Huang, Stuart B. Rosenblum, Chuan Kui Jiang, Haiyan Pu, Tin Yau Chan, Eric Ferrari, George F Njoroge, Joseph A. Kozlowski, Sony Agrawal, Henry M. Vaccaro, Mousumi Sannigrahi, Qingbei Zeng, Patricia McMonagle, Oleg Selyutin
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
SAR development of indole-based palm site inhibitors of HCV NS5B polymerase exemplified by initial indole lead 1 (NS5B IC50 = 0.9 μM, replicon EC50 >100 μM) is described. Structure-based drug design led to the incorporation of novel heterocyclic mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbcde4c34dd48082f61c28f48aee1b2
https://pubmed.ncbi.nlm.nih.gov/21840715
https://pubmed.ncbi.nlm.nih.gov/21840715
Autor:
Taveras Arthur G, W. Robert Bishop, Michael Sinensky, Doll Ronald J, Marguerite B. Dalton, Lydia Armstrong, Paul Kirschmeier, Ming Liu, Fang Zhang, George F. Njoroge, James J.-K. Pai
Publikováno v:
Farnesyltransferase Inhibitors in Cancer Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a87ab510dfc7428cbc9652fea966b77
https://doi.org/10.1385/1-59259-013-6:87
https://doi.org/10.1385/1-59259-013-6:87
Autor:
Jeffry J. Winemiller, George F. Njoroge, Kirtivan D. Kotian, J. Eric Nordlander, Dwight E. Raff
Publikováno v:
Journal of the American Chemical Society. 106:1427-1432
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ef2cde3507967282919a1ccd2c2f87f
https://doi.org/10.1021/ja00317a039
https://doi.org/10.1021/ja00317a039
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