Zobrazeno 1 - 10
of 64
pro vyhledávání: '"George F. Kalf"'
Autor:
Robert R. Snyder, James J. Kocsis, I. Glenn Sipes, George F. Kalf, David J. Jollow, Helmut Greim, Terrence J. Monks, Charlotte M. Witmer
Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam ples of enzymatically catalyzed reactions in which normal body constituen
The finding that chemicals can be metabolically activated to yield reactive chemical species capable of covalently binding to cellular macromolecules and the concept that these reactions could initiate toxicological and carcinogenic events stimulated
Autor:
George F. Kalf, Anna M. Hutt
Publikováno v:
Environmental Health Perspectives
Chronic exposure of humans to benzene (BZ) causes acute myeloid leukemia (AML). Both BZ and therapy-related secondary AML are characterized by chromosomal translocations that may occur by inappropriate recombinational events. DNA topoisomerase II (to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::479e4cc4f224060bd190600ce719e70d
https://doi.org/10.1289/ehp.961041265
https://doi.org/10.1289/ehp.961041265
Publikováno v:
STEM CELLS. 14:730-742
Hydroquinone (a major marrow metabolite of the leukemogen, benzene) induces incomplete granulocytic differentiation of mouse myeloblasts to the myelocyte stage, and also causes an increase in the number of myelocytes. This was confirmed using the nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe53ba0571f3f05df2947533a49a66e
https://doi.org/10.1002/stem.140730
https://doi.org/10.1002/stem.140730
Autor:
Robert Snyder, George F. Kalf
Publikováno v:
Critical Reviews in Toxicology. 24:177-209
Although benzene is best known as a compound that causes bone marrow depression leading to aplastic anemia in animals and humans, it also induces acute myelogenous leukemia in humans. The epidemiological evidence for leukemogenesis in humans is contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7a567c114176fd9c10dec385ee1b59
https://doi.org/10.3109/10408449409021605
https://doi.org/10.3109/10408449409021605
Autor:
Annette O'Connor, George F. Kalf
Publikováno v:
Leukemia & Lymphoma. 11:331-338
Chronic exposure of humans to benzene (BZ) affects hematopoietic progenitor cells in intermediate stages of differentiation which can lead to aplastic anemia and/or acute myelogenous leukemia and some of its variant forms. We studied the effects of B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2214c6a5651dd0cc628bf33ad1c749
https://doi.org/10.3109/10428199309067923
https://doi.org/10.3109/10428199309067923
Autor:
George F. Kalf, Nancy L. Oliveira
Publikováno v:
Blood. 79:627-633
Chronic exposure of humans to benzene has been shown to have a cytotoxic effect on hematopoietic progenitor cells in intermediate stages of differentiation, which can lead to aplastic anemia and acute myelogenous leukemia. We studied the effect of hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ef83ffe8051773fcbeef70bf7752681
https://doi.org/10.1182/blood.v79.3.627.627
https://doi.org/10.1182/blood.v79.3.627.627
Autor:
John F. Renz, George F. Kalf
Publikováno v:
Blood. 78:938-944
Chronic exposure of humans to benzene (BZ), a myelotoxin, causes aplastic anemia and acute leukemia. The stromal macrophage that produces interleukin-1 (IL-1), a cytokine essential for hematopoiesis, is a target of BZ's toxicity. Monocyte dysfunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e874de9a4b15587c9cf728b5397e815b
https://doi.org/10.1182/blood.v78.4.938.938
https://doi.org/10.1182/blood.v78.4.938.938
Autor:
James W. Karaszkiewicz, George F. Kalf
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1035:223-229
An enzyme has been purified to electrophoretic homogeneity from rat liver mitoplasts which metabolizes benzene to phenol. The enzyme has a Mr of 52,000 and requires NADPH, adrendoxin, and adrenodoxin reductase for activity. Benzene hydroxylase activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e9cc19338c3fa5c3bf657659adb366
https://doi.org/10.1016/0304-4165(90)90121-c
https://doi.org/10.1016/0304-4165(90)90121-c
Publikováno v:
Chemical Research in Toxicology. 3:333-339
Hydroquinone, a metabolite that accumulates in bone marrow following benzene exposure, was oxidized by prostaglandin H synthase (PHS) to 1,4-benzoquinone, which was measured by HPLC with reductive electrochemistry. Hydroquinone metabolism in the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ba998f5fc5bacb04b4442968c82ec1
https://doi.org/10.1021/tx00016a010
https://doi.org/10.1021/tx00016a010