Zobrazeno 1 - 10
of 13
pro vyhledávání: '"George F. Huhn"'
Publikováno v:
The Journal of Organic Chemistry. 65:7718-7722
2-Fluoro-4-methylpyridine (3) is efficiently functionalized by chlorination, hydrolysis and methanesulfonylation into the novel alkylating agent 7. This mesylate is used for the bisalkylation of anthrone under carefully defined conditions to prepare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd9f3bd93c42115a3018c530c6e597a
https://doi.org/10.1021/jo9804339
https://doi.org/10.1021/jo9804339
Publikováno v:
Organic Process Research & Development. 2:105-110
The end point, rates of reaction, and heat of reaction have been determined for the reaction of 1,10-dibromodecane and 1,6-hexamethylenediamine, which forms a moderately cross-linked polymer useful as a bile acid sequestrant in the treatment of eleva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc8c2cb56579c61a78200262119437af
https://doi.org/10.1021/op970243k
https://doi.org/10.1021/op970243k
Autor:
Mark D. Lauritsen, Goss S. Kauffman, Kimberly A. Nelson, Walter M. Bryant, Richard E. Olson, Gary O. Page, Lisa M. Lloyd, James Segretario, George F. Huhn, John F. Arnett, Pesti Jaan A, Christopher S. Bamum, Edward F. Gorko, Jill A. Downard, Robert E. Yule, Joseph J. Mrowca
Publikováno v:
Journal of Heterocyclic Chemistry. 35:249-255
The methanesulfonates of (α-(4-chlorophenyl)-α-[1-(2-chlorophenyl)ethenyl]-1H-1,2,4-triazole-1-ethanol and α-[1-(2-chlorophenyl)ethenyl]-α-(2,4-difluorophenyl)-1H-1,2,4-triazole-1-ethanol (1a, b) are orally effective α-styryl carbinol derivative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4e11eec83289b50d611174679ccae58
https://doi.org/10.1002/jhet.5570350144
https://doi.org/10.1002/jhet.5570350144
Autor:
George F. Huhn, Walter M. Bryant
Publikováno v:
Synthetic Communications. 25:915-920
A practical new synthesis suitable for large-scale production of 7-methoxy-3(2H)-benzofuranone by conversion of commercially available 2-hydroxy-3-methoxybenzoic acid to 7-methoxy-3-acetoxybenzofuran followed by hydrolysis is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ea5807fa5475ee5bc94a9ac9c165ae8
https://doi.org/10.1080/00397919508013429
https://doi.org/10.1080/00397919508013429
Autor:
Ken W. Sigvardson, James Henry Jensen, George F. Huhn, Yide Xing, Q. Islam, Michael E. Pierce
Publikováno v:
Journal of Heterocyclic Chemistry. 31:17-23
Sodium borohydride reduction of 1-phenyl-3-(4-pyridinylmethylene)-2-oxindole 1 in methanol gives a high yield of the oxindole 2, a precursor to linopirdine. The reduction is accelerated by methanol and the major by-products during this reduction are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86a6cb797b8fb8cd87e69752d5c9de9c
https://doi.org/10.1002/jhet.5570310103
https://doi.org/10.1002/jhet.5570310103
Publikováno v:
Separation Science and Technology. 28:1959-1970
Inosine- and uridine-5′-diphosphates can be purified by ion-exchange chromatography utilizing a new ion-exchange method where Type 1 ion-exchange resins and the absorbed nucleoside polyphosphates are changed to the basic form by rinsing the column
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc83b4c64302d9b51056b697647b76fd
https://doi.org/10.1080/01496399308016726
https://doi.org/10.1080/01496399308016726
Publikováno v:
The Journal of Organic Chemistry. 58:4642-4645
DuP 532 (2), which is a potent angiotensin II receptor antagonist, has been prepared by two different routes. One route, which is more practical for large-scale synthesis, required the preparation of methyl 4(5)-(pentafluoroethyl)-2-propylimidazole-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1d1d4268cd709410a483885ffa73b51
https://doi.org/10.1021/jo00069a029
https://doi.org/10.1021/jo00069a029
Publikováno v:
Synthetic Communications. 23:1617-1625
Linopirdine is a pharmacologically potent drug which stimulates central nervous system neurotransmitter release. A facile process used to synthesize linopirdine on a commercial manufacturing scale consisting of seven chemical steps with only a single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0812812fc4579e6f02621917b06c08a9
https://doi.org/10.1080/00397919308011258
https://doi.org/10.1080/00397919308011258
Publikováno v:
ChemInform. 24
DuP 532 (2), which is a potent angiotensin II receptor antagonist, has been prepared by two different routes. One route, which is more practical for large-scale synthesis, required the preparation of methyl 4(5)-(pentafluoroethyl)-2-propylimidazole-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffab6b066693bcb4d9c2015415df3515
https://doi.org/10.1002/chin.199351154
https://doi.org/10.1002/chin.199351154
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::743c2464df1fc94c2c40568223ae4260
https://doi.org/10.1002/chin.199403148
https://doi.org/10.1002/chin.199403148