Zobrazeno 1 - 10
of 10
pro vyhledávání: '"George F. Dorsey"'
Autor:
George F. Dorsey, Maosheng Duan, Robert G. Ferris, Christopher Joseph Aquino, Wieslaw M. Kazmierski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4988-4992
A series of 4,4-disubstituted cyclohexylamine based CCR5 antagonists has been designed and synthesized. Their antiviral structure-activity relationship has been extensively explored.
Publikováno v:
Magnetic Resonance in Chemistry. 46:558-563
We describe here new versions of the DEPT phase-encoded HMQC experiment that offer robust performance and improved sensitivity. The new sequences rely on frequency-swept proton and carbon pulses to minimize signal losses from miscalibrated pulses whi
Publikováno v:
Magnetic Resonance in Chemistry. 46:564-570
This article describes new versions of the DEPT phase-edited heteronuclear single quantum correlation (HSQC) pulse sequence with sensitivity enhancement. The sequences incorporate frequency-swept carbon and proton pulses. The new experiments are inhe
Autor:
Renae M. Crosby, Christopher Mohr, Daniel D. Sternbach, Steven R. Jordan, Krystal J. Alligood, Paul L. Feldman, Paul S. Charifson, George F. Dorsey, Conrad W. Hummel, Judd Berman, Lisa M. Shewchuk, Gregory J. Pacofsky, Marc Rodriguez, Tona M. Gilmer, Karen Lackey
Publikováno v:
Journal of Medicinal Chemistry. 41:1894-1908
The design, synthesis, and evaluation of dipeptide analogues as ligands for the pp60c-src SH2 domain are described. The critical binding interactions between Ac-Tyr-Glu-N(n-C5H11)2 (2) and the protein are established and form the basis for our struct
Autor:
Dan Todd, George W. Koszalka, Richard F. Cox, Jeffrey H. Tidwell, Graham Whitesell, Jeffrey A. Stafford, Robert P. Wiard, Gregory J. Pacofsky, Paul L. Feldman, George G. Lovell, Stephen S. Gonzales, Jill R. Cowan, Maggie S. McIntyre, Istvan Kaldor, George F. Dorsey
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(21)
The ultrashort-acting benzodiazepine (USA BZD) agonists reported previously have been structurally modified to improve aqueous solubility. Lactam-to-amidine modifications, replacement of the C5-haloaryl ring, and annulation of heterocycles are presen
Autor:
David Kendall Jung, Jeffrey A. Stafford, Maggie S. McIntyre, George F. Dorsey, Robert P. Wiard, Gregory J. Pacofsky, Jeffrey H. Tidwell, Paul L. Feldman, Jill R. Cowan, George W. Koszalka, Richard F. Cox, Stephen S. Gonzales
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(21)
The synthesis and evaluation of novel ultrashort-acting benzodiazepine (USA BZD) agonists is described. A BZD scaffold was modified by incorporation of amino acids and derivatives. The propionate side chain of glutamic acid tethers an enzymatically l
Autor:
James E. Long, J. Darren Stuart, Timothy K. Tippin, Marcia L. Moss, Dallas K. Croom, Michael K. James, Stephen V. Frye, Frank W. Lee, D. Mark Bickett, Kenneth William Batchelor, Curt Dale Haffner, John Van Arnold, George F. Dorsey, Patrick R. Maloney, Rayomand J. Unwalla, Stephanie L. Schweiker, Roger N. Hiner, H. Neal Bramson, Gaochoa Tian, Mary K. Grizzle, Robert A. Noe
Publikováno v:
Journal of medicinal chemistry. 38(14)
A variety of C17 amide-substituted 6-azaandrost-4-en-3-ones were prepared and tested versus human type 1 and 2 steroid 5 alpha-reductase (5AR) and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase (3BHSD) in
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