Zobrazeno 1 - 10
of 69
pro vyhledávání: '"George F. Atweh"'
Autor:
Kurt R. Oettel, Edward L. Nelson, Merry Jennifer Markham, Claire F. Verschraegen, Lisa A. Carey, Julie M. Vose, George F. Atweh, Wells A. Messersmith, Martin J. Edelman, Philip W. Kantoff, Ruth O'Regan, Jenny C. Chang, Ravi Bhatia, Lowell B. Anthony
Publikováno v:
JCO Oncol Pract
JCO oncology practice, vol 17, iss 3
JCO oncology practice, vol 17, iss 3
The role of clinical researchers is vital to cancer progress. The teaching, research, and leadership roles that academic oncologists hold need to be accounted for and appropriately compensated. National metrics are currently inexistent, but are neces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab7d6f1db9f42484f88563581d4168a
https://europepmc.org/articles/PMC8462569/
https://europepmc.org/articles/PMC8462569/
Autor:
George F. Atweh, Charmaine A. Ramlogan-Steel, Camelia Iancu-Rubin, Jason C. Steel, Hassana Fathallah
Publikováno v:
Blood Cells, Molecules, and Diseases. 87:102522
Stathmin 1 (STMN1) is a cytosolic phosphoprotein that was discovered as a result of its high level of expression in leukemic cells. It plays an important role in the regulation of mitosis by promoting depolymerization of the microtubules that make up
Autor:
Deepa Manwani, Henny H. Billett, Hillel W. Cohen, Stelian Serban, Matthew A. Huggins, Patricia A. Shi, Grace Chen, Veronica Carullo, Jungeun Jang, Olugbenga Olowokure, George F. Atweh, Paul S. Frenette
Publikováno v:
American Journal of Hematology. 90:381-385
Intravenous immunoglobulin (IVIG) decreases neutrophil adhesion to endothelium and red blood cell-neutrophil interactions in sickle cell mice undergoing vaso-occlusion. In this Phase I clinical trial of sickle cell anemia (SCA) patients admitted with
Autor:
Prasad Devarajan, Jamie Wilhelm, Michael J. Bennett, George F. Atweh, Punam Malik, Mi-Ok Kim, Nambirajan Sundaram
Publikováno v:
American Journal of Hematology. 86:559-566
Renal complications affect nearly 30–50% of adults with sickle cell anemia (SCA), causing significant morbidity and mortality. Standard renal function tests like serum creatinine and glomerular filtration rate become abnormal in this disease only w
Publikováno v:
Blood Cells, Molecules, and Diseases. 40:166-173
K562 erythroleukemia cells have been widely used as a model for the study of globin gene regulation. A number of agents have been shown to activate or suppress globin gene expression in these cells. However, the molecular effects of these agents on t
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 40:2341-2347
Epigenomic modifiers, such as histone deacetylase inhibitors, are compounds that regulate gene expression by interfering with the enzymatic machinery that maintains the proper chromatin structure of the nucleus. These compounds are at the forefront o
Publikováno v:
Blood. 110:3391-3397
Butyrate is a prototype of histone deacetylase inhibitors that is believed to reactivate silent genes by inducing epigenetic modifications. Although butyrate was shown to induce fetal hemoglobin (HbF) production in patients with hemoglobin disorders,
Autor:
George F. Atweh, Hassana Fathallah
Publikováno v:
Hematology. 2006:58-62
Reactivation of fetal hemoglobin (HbF) expression is an important therapeutic option in patients with hemoglobin disorders. In sickle cell disease (SCD), an increase in HbF inhibits the polymerization of sickle hemoglobin and the resulting pathophysi
Publikováno v:
Annals of the New York Academy of Sciences. 1054:228-237
The first studies of the pharmacological induction of fetal hemoglobin were conducted in patients with sickle cell disease and thalassemia. Although hydroxyurea was approved by the FDA for the treatment of sickle cell disease in 1996, no similar phar
Publikováno v:
Cell Cycle. 4:1774-1782
Physiological polyploidy is a characteristic of several cell types including the megakaryocytes (MK) that give rise to circulating blood platelets. MK achieve polyploidy by switching from a normal to an endomitotic cell cycle characterized by the abs