Zobrazeno 1 - 10
of 212
pro vyhledávání: '"George Eng"'
Autor:
George Eng, Benjamin W. Lee, Lev Protas, Mark Gagliardi, Kristy Brown, Robert S. Kass, Gordon Keller, Richard B. Robinson, Gordana Vunjak-Novakovic
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The use of stem cell-derived cardiomyocytes for heart repair is hampered by their immature structural and contractile properties that may cause arrhythmia. Here, Eng et al.show that electrical conditioning of human cardiomyocytes in 3D culture can en
Externí odkaz:
https://doaj.org/article/413621c69f534affb5ac9f42218483c9
Autor:
Martin S Taylor, Ilya Altukhov, Kelly R Molloy, Paolo Mita, Hua Jiang, Emily M Adney, Aleksandra Wudzinska, Sana Badri, Dmitry Ischenko, George Eng, Kathleen H Burns, David Fenyö, Brian T Chait, Dmitry Alexeev, Michael P Rout, Jef D Boeke, John LaCava
Publikováno v:
eLife, Vol 7 (2018)
Long Interspersed Nuclear Element-1 (LINE-1, L1) is a mobile genetic element active in human genomes. L1-encoded ORF1 and ORF2 proteins bind L1 RNAs, forming ribonucleoproteins (RNPs). These RNPs interact with diverse host proteins, some repressive a
Externí odkaz:
https://doaj.org/article/38c0c1b5394448678742820310960994
Autor:
Jung-Kuei Chen, Karl A. Merrick, Yi Wen Kong, Anita Izrael-Tomasevic, George Eng, Erika D. Handly, Jesse C. Patterson, Ian G. Cannell, Lucia Suarez-Lopez, Aaron M. Hosios, Anh Dinh, Donald S. Kirkpatrick, Kebing Yu, Christopher M. Rose, Jonathan M. Hernandez, Haeun Hwangbo, Adam C. Palmer, Matthew G. Vander Heiden, Ömer H. Yilmaz, Michael B. Yaffe
Publikováno v:
bioRxiv
5-fluorouracil (5-FU) is a successful and broadly used anti-cancer therapeutic. A major mechanism of action of 5-FU is thought to be through thymidylate synthase (TYMS) inhibition resulting in dTTP depletion and activation of the DNA damage response.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadd78608f21d007548dbd022c63b683
https://doi.org/10.1101/2023.04.28.538590
https://doi.org/10.1101/2023.04.28.538590
Autor:
Martin S. Taylor, Connie Wu, Peter C. Fridy, Stephanie J. Zhang, Yasmeen Senussi, Justina C. Wolters, Wen-Chih Cheng, John Heaps, Bryant D. Miller, Kei Mori, Limor Cohen, Hua Jiang, Kelly R. Molloy, Brian T. Chait, Michael Goggins, Irun Bhan, Joseph W. Franses, Xiaoyu Yang, Mary-Ellen Taplin, Xinan Wang, David C. Christiani, Bruce E. Johnson, Matthew Meyerson, Ravindra Uppaluri, Ann Marie Egloff, Elyssa N. Denault, Laura M. Spring, Tian-Li Wang, Ie-Ming Shih, Euihye Jung, Kshitij S. Arora, Lawrence R. Zukerberg, Osman H. Yilmaz, Gary Chi, Bryanna L. Norden, Yuhui Song, Linda Nieman, Aparna R. Parikh, Matthew Strickland, Ryan B. Corcoran, Tomas Mustelin, George Eng, Ömer H. Yilmaz, Ursula A. Matulonis, Steven J. Skates, Bo R. Rueda, Ronny Drapkin, Samuel J. Klempner, Vikram Deshpande, David T. Ting, Michael P. Rout, John LaCava, David R. Walt, Kathleen H. Burns
Publikováno v:
bioRxiv
Improved biomarkers are needed for early cancer detection, risk stratification, treatment selection, and monitoring treatment response. While proteins can be useful blood-based biomarkers, many have limited sensitivity or specificity for these applic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cdcf66174cd5676ee31b3db57f28b9f
https://hdl.handle.net/11370/41ca3c33-d273-45a6-bf29-9274abc151ef
https://hdl.handle.net/11370/41ca3c33-d273-45a6-bf29-9274abc151ef
Publikováno v:
New England Journal of Medicine. 385:1894-1902
A Man with Altered Mental Status and New Onset of Seizures A 38-year-old man was evaluated in the emergency department because of altered mental status and a first seizure. Examination revealed an ...
Autor:
Alex M. Jaeger, JJ Patten, Olivia Smith, Haley Hauck, Ömer H. Yilmaz, Tyler Jacks, George Eng, Peter M. K. Westcott, Jason M. Schenkel, Coralie Backlund, Ryan Elbashir, Darrell J. Irvine, Zackery A. Ely, Daniel Zhang, Nathan J. Sacks, Mary Clare Beytagh
Publikováno v:
Nature Cancer. 2:1071-1085
Immune evasion is a hallmark of cancer and therapies that restore immune surveillance have proven highly effective in cancers with high tumor mutation burden (TMB) (for example, those with microsatellite instability). Whether low TMB cancers, which a
Autor:
Douglas S. Kwon, Seyed Alireza Rabi, Richard A. Hodin, Laura E. Avena, Anthony Griffiths, Meaghan Flagg, James R. Stone, Manish Chandra Choudhary, Isabella Gomez, Derek J. Erstad, Virginia A. Triant, Ömer H. Yilmaz, George Eng, Mara Farcasanu, Larance Ronsard, Grace C. Lee, Daniel Lingwood, George C. Velmahos, Thomas J. Diefenbach, Upasana Das Adhikari, Anna N. Honko, Leah M Froehle, Abigail E. Schiff, Jonathan Z. Li
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
The clinical significance of severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) RNA in stool remains uncertain. We found that extrapulmonary dissemination of infection to the gastrointestinal tract, assessed by the presence of SARS-CoV-2 RN
Autor:
William L. Hwang, Karthik A. Jagadeesh, Jimmy A. Guo, Hannah I. Hoffman, Payman Yadollahpour, Jason W. Reeves, Rahul Mohan, Eugene Drokhlyansky, Nicholas Van Wittenberghe, Orr Ashenberg, Samouil L. Farhi, Denis Schapiro, Prajan Divakar, Eric Miller, Daniel R. Zollinger, George Eng, Jason M. Schenkel, Jennifer Su, Carina Shiau, Patrick Yu, William A. Freed-Pastor, Domenic Abbondanza, Arnav Mehta, Joshua Gould, Conner Lambden, Caroline B. M. Porter, Alexander Tsankov, Danielle Dionne, Julia Waldman, Michael S. Cuoco, Lan Nguyen, Toni Delorey, Devan Phillips, Jaimie L. Barth, Marina Kem, Clifton Rodrigues, Debora Ciprani, Jorge Roldan, Piotr Zelga, Vjola Jorgji, Jonathan H. Chen, Zackery Ely, Daniel Zhao, Kit Fuhrman, Robin Fropf, Joseph M. Beechem, Jay S. Loeffler, David P. Ryan, Colin D. Weekes, Cristina R. Ferrone, Motaz Qadan, Martin J. Aryee, Rakesh K. Jain, Donna S. Neuberg, Jennifer Y. Wo, Theodore S. Hong, Ramnik Xavier, Andrew J. Aguirre, Orit Rozenblatt-Rosen, Mari Mino-Kenudson, Carlos Fernandez-del Castillo, Andrew S. Liss, David T. Ting, Tyler Jacks, Aviv Regev
Publikováno v:
Nat Genet
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory cancer. Molecular stratification in pancreatic cancer remains rudimentary and does not yet inform clinical management or therapeutic development. Here, we construct a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52fea7e3e72f452826d1f68df747811
https://europepmc.org/articles/PMC10290535/
https://europepmc.org/articles/PMC10290535/
Publikováno v:
Open Journal of Urology. 11:1-5
Background: Penile metastasis of colorectal carcinoma is a rare phenomenon in clinical setting. They normally manifest as penile lesion and acute urinary retention. However, presentation of priapism is exceedingly rare. Aims: Discussion of this rare
Publikováno v:
Journal of Coordination Chemistry. 73:2085-2094
Two ionic triphenyltin complexes were obtained when two thiocarboxylic acids, mercaptoacetic acid and 3-mercaptopropionic acid, were mixed with triphenyltin hydroxide in the presence of dicylcohexy...