Data from Breast Cancer Dormancy Can Be Maintained by Small Numbers of Micrometastases

Autor: Karen M. Page, Trevor A. Graham, Ian P.M. Tomlinson, Nick A. Wright, J. Louise Jones, George Elia, Tomas Alarcón, Lisa Willis

Late relapse of breast cancer can occur more than 25 years after primary diagnosis. During the intervening years between initial treatment and relapse, occult cancers are maintained in an apparent state of dormancy that is poorly understood. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa1eaa2bb0c05032da100d3878102f04
https://doi.org/10.1158/0008-5472.c.6500331

Data from Bone Marrow–Derived Stromal Cells Express Lineage-Related Messenger RNA Species

Autor: Malcolm R. Alison, Nicholas A. Wright, Richard Poulsom, George Elia, Raymond J. Playford, Toby Hunt, Kairbaan Hodivala-Dilke, Rosemary Jeffery, Natalie C. Direkze

Evidence has emerged that bone marrow cells have a greater degree of plasticity than previously thought. However, there has been a call to establish proof that these bone marrow–derived cells function appropriately in their new environment. We have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f698cfc7183bd61a6eab565a7a4e19c
https://doi.org/10.1158/0008-5472.c.6494787.v1

Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon

Autor: Ann-Marie Baker, Biancastella Cereser, Samuel Melton, Alexander G. Fletcher, Manuel Rodriguez-Justo, Paul J. Tadrous, Adam Humphries, George Elia, Stuart A.C. McDonald, Nicholas A. Wright, Benjamin D. Simons, Marnix Jansen, Trevor A. Graham

Publikováno v: Cell Reports, Vol 8, Iss 4, Pp 940-947 (2014)

Human intestinal stem cell and crypt dynamics remain poorly characterized because transgenic lineage-tracing methods are impractical in humans. Here, we have circumvented this problem by quantitatively using somatic mtDNA mutations to trace clonal li

Externí odkaz: https://doaj.org/article/5803d8f2cc1e4ffd817fc85712de1e0b

Clonal Transitions and Phenotypic Evolution in Barrett's Esophagus

Autor: James A. Evans, Emanuela Carlotti, Meng-Lay Lin, Richard J. Hackett, Magnus J. Haughey, Adam M. Passman, Lorna Dunn, George Elia, Ross J. Porter, Mairi H. McLean, Frances Hughes, Joanne ChinAleong, Philip Woodland, Sean L. Preston, S. Michael Griffin, Laurence Lovat, Manuel Rodriguez-Justo, Weini Huang, Nicholas A. Wright, Marnix Jansen, Stuart A.C. McDonald

Publikováno v: Evans, J A, Carlotti, E, Lin, M-L, Hackett, R J, Haughey, M J, Passman, A M, Dunn, L, Elia, G, Porter, R J, McLean, M H, Hughes, F, ChinAleong, J, Woodland, P, Preston, S L, Griffin, S M, Lovat, L, Rodriguez-Justo, M, Huang, W, Wright, N A, Jansen, M & McDonald, S A C 2021, ' Clonal Transitions and Phenotypic Evolution in Barrett's Esophagus ', Gastroenterology . https://doi.org/10.1053/j.gastro.2021.12.271

BACKGROUND & AIMS: Barrett's esophagus (BE) is a risk factor for esophageal adenocarcinoma but our understanding of how it evolves is poorly understood. We investigated BE gland phenotype distribution, the clonal nature of phenotypic change, and how

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ce501697431493a43d2e17fdea462c
https://hdl.handle.net/20.500.11820/86dd8044-f515-481a-8ca6-c44362bdc748

Stromal Claudin14-heterozygosity, but not deletion, increases tumour blood leakage without affecting tumour growth.

Autor: Marianne Baker, Louise E Reynolds, Stephen D Robinson, Delphine M Lees, Maddy Parsons, George Elia, Kairbaan Hodivala-Dilke

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e62516 (2013)

The maintenance of endothelial cell-cell junctions is vital for the control of blood vessel leakage and is known to be important in the growth and maturation of new blood vessels during angiogenesis. Here we have investigated the role of a tight junc

Externí odkaz: https://doaj.org/article/65ff3c9f977a4399ac2c953da2c108a7