A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells

Autor: Jonathan W. Cruz, Ermelinda Damko, Bhavika Modi, Naxin Tu, Karoline Meagher, Vera Voronina, Hans Gartner, George Ehrlich, Ashique Rafique, Robert Babb, Priya Aneja, Terra B. Potocky, Amanda D’ Orvilliers, Alida Coppi, Sook Yen E, Haibo Qiu, Courtney M. Williams, Brandy L. Bennett, Gang Chen, Lynn Macdonald, William Olson, John C. Lin, Neil Stahl, Andrew J. Murphy, Christos A. Kyratsous, Brinda C. Prasad

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)

Abstract Harnessing complement-mediated cytotoxicity by therapeutic antibodies has been limited because of dependency on size and density of antigen, structural constraints resulting from orientation of antibody binding, and blockade of complement ac

Externí odkaz: https://doaj.org/article/a1c56187022f4047924380652a772499

CONGESTIVE HEART FAILURE: EXPERIMENTAL MODEL

Autor: Antonio Francesco Corno, Xue eCai, Caroline B Jones, Giuseppina eMondani, Mark R. Boyett, Jonathan Charles Jarvis, George eHart

Publikováno v: Frontiers in Pediatrics, Vol 1 (2013)

INTRODUCTION.Surgically induced, combined volume and pressure overload has been used in rabbits to create a simplified and reproducible model of acute left ventricular (LV) failure.MATERIALS AND METHODS.New Zealand white male rabbits (n=24, mean weig

Externí odkaz: https://doaj.org/article/28ae5c1419cb4221a33a5f986b99e3c1

Long-distance travel for birthing among Indigenous and non-Indigenous pregnant people in Canada.

Autor: Smylie J; Well Living House (Smylie), St. Michael's Hospital; Dalla Lana School of Public Health (Smylie), University of Toronto; Ontario HIV Treatment Network (O'Brien); Midwifery Education Program (Bourgeois), Ryerson University; Seventh Generations Midwives Toronto (Bourgeois), Toronto, Ont.; Department of Public Health (Daoud), Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel; National Aboriginal Council of Midwives (Harney George, Bebee), BC; Native Women's Association of Canada (Ryan), Ont.; Bridlewood Medical Centre (Beaudoin), Kanata, Ont. janet.smylie@utoronto.ca., O'Brien K; Well Living House (Smylie), St. Michael's Hospital; Dalla Lana School of Public Health (Smylie), University of Toronto; Ontario HIV Treatment Network (O'Brien); Midwifery Education Program (Bourgeois), Ryerson University; Seventh Generations Midwives Toronto (Bourgeois), Toronto, Ont.; Department of Public Health (Daoud), Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel; National Aboriginal Council of Midwives (Harney George, Bebee), BC; Native Women's Association of Canada (Ryan), Ont.; Bridlewood Medical Centre (Beaudoin), Kanata, Ont., Beaudoin E; Well Living House (Smylie), St. Michael's Hospital; Dalla Lana School of Public Health (Smylie), University of Toronto; Ontario HIV Treatment Network (O'Brien); Midwifery Education Program (Bourgeois), Ryerson University; Seventh Generations Midwives Toronto (Bourgeois), Toronto, Ont.; Department of Public Health (Daoud), Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel; National Aboriginal Council of Midwives (Harney George, Bebee), BC; Native Women's Association of Canada (Ryan), Ont.; Bridlewood Medical Centre (Beaudoin), Kanata, Ont., Daoud N; Well Living House (Smylie), St. Michael's Hospital; Dalla Lana School of Public Health (Smylie), University of Toronto; Ontario HIV Treatment Network (O'Brien); Midwifery Education Program (Bourgeois), Ryerson University; Seventh Generations Midwives Toronto (Bourgeois), Toronto, Ont.; Department of Public Health (Daoud), Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel; National Aboriginal Council of Midwives (Harney George, Bebee), BC; Native Women's Association of Canada (Ryan), Ont.; Bridlewood Medical Centre (Beaudoin), Kanata, Ont., Bourgeois C; Well Living House (Smylie), St. Michael's Hospital; Dalla Lana School of Public Health (Smylie), University of Toronto; Ontario HIV Treatment Network (O'Brien); Midwifery Education Program (Bourgeois), Ryerson University; Seventh Generations Midwives Toronto (Bourgeois), Toronto, Ont.; Department of Public Health (Daoud), Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel; National Aboriginal Council of Midwives (Harney George, Bebee), BC; Native Women's Association of Canada (Ryan), Ont.; Bridlewood Medical Centre (Beaudoin), Kanata, Ont., George EH; Well Living House (Smylie), St. Michael's Hospital; Dalla Lana School of Public Health (Smylie), University of Toronto; Ontario HIV Treatment Network (O'Brien); Midwifery Education Program (Bourgeois), Ryerson University; Seventh Generations Midwives Toronto (Bourgeois), Toronto, Ont.; Department of Public Health (Daoud), Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel; National Aboriginal Council of Midwives (Harney George, Bebee), BC; Native Women's Association of Canada (Ryan), Ont.; Bridlewood Medical Centre (Beaudoin), Kanata, Ont., Bebee K; Well Living House (Smylie), St. Michael's Hospital; Dalla Lana School of Public Health (Smylie), University of Toronto; Ontario HIV Treatment Network (O'Brien); Midwifery Education Program (Bourgeois), Ryerson University; Seventh Generations Midwives Toronto (Bourgeois), Toronto, Ont.; Department of Public Health (Daoud), Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel; National Aboriginal Council of Midwives (Harney George, Bebee), BC; Native Women's Association of Canada (Ryan), Ont.; Bridlewood Medical Centre (Beaudoin), Kanata, Ont., Ryan C; Well Living House (Smylie), St. Michael's Hospital; Dalla Lana School of Public Health (Smylie), University of Toronto; Ontario HIV Treatment Network (O'Brien); Midwifery Education Program (Bourgeois), Ryerson University; Seventh Generations Midwives Toronto (Bourgeois), Toronto, Ont.; Department of Public Health (Daoud), Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel; National Aboriginal Council of Midwives (Harney George, Bebee), BC; Native Women's Association of Canada (Ryan), Ont.; Bridlewood Medical Centre (Beaudoin), Kanata, Ont.

Publikováno v: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne [CMAJ] 2021 Jun 21; Vol. 193 (25), pp. E948-E955.

Inactivation of rabies diagnostic reagents by gamma radiation.

Autor: Gamble WC, Chappell WA, George EH

Publikováno v: Journal of clinical microbiology [J Clin Microbiol] 1980 Nov; Vol. 12 (5), pp. 676-8.

Persistence of complement-fixing antibodies in guinea pig sera serially collected in large volumes.

Autor: Gamble WC, Chappell WA, George EH

Publikováno v: Laboratory animal science [Lab Anim Sci] 1974 Aug; Vol. 24 (4), pp. 605-9.