Zobrazeno 1 - 10
of 100
pro vyhledávání: '"George E.O. Muscat"'
Autor:
Mitchell E. Fane, Yash Chhabra, David E.J. Hollingsworth, Jacinta L. Simmons, Loredana Spoerri, Tae Gyu Oh, Jagat Chauhan, Toby Chin, Lachlan Harris, Tracey J. Harvey, George E.O. Muscat, Colin R. Goding, Richard A Sturm, Nikolas K. Haass, Glen M. Boyle, Michael Piper, Aaron G. Smith
Publikováno v:
EBioMedicine, Vol 16, Iss C, Pp 63-75 (2017)
While invasion and metastasis of tumour cells are the principle factor responsible for cancer related deaths, the mechanisms governing the process remain poorly defined. Moreover, phenotypic divergence of sub-populations of tumour cells is known to u
Externí odkaz:
https://doaj.org/article/1d9c7e7e95224d40a32f42bb4b0ce6d1
Autor:
Zewen Kelvin Tuong, Rebecca Fitzsimmons, Shu-Ching Mary Wang, Tae Gyu Oh, Patrick Lau, Frederik Steyn, Gethin Thomas, George E.O. Muscat
Publikováno v:
EBioMedicine, Vol 11, Iss C, Pp 101-117 (2016)
RORα is a member of the nuclear receptor (NR) superfamily and analysis of the (global) RORα-deficient mouse model revealed this NR has a role in glycemic control and fat deposition. Therefore, we generated an adipose-specific RORα ‘gain of funct
Externí odkaz:
https://doaj.org/article/9a268d51f1f44530b3a43e3c6d5584ac
Autor:
Manuel A. Fernández-Rojo, Milena Gongora, Rebecca L. Fitzsimmons, Nick Martel, Sheree D. Martin, Susan J. Nixon, Andrew J. Brooks, Maria P. Ikonomopoulou, Sally Martin, Harriet P. Lo, Stephen A. Myers, Christina Restall, Charles Ferguson, Paul F. Pilch, Sean L. McGee, Robin L. Anderson, Michael J. Waters, John F. Hancock, Sean M. Grimmond, George E.O. Muscat, Robert G. Parton
Publikováno v:
Cell Reports, Vol 4, Iss 2, Pp 238-247 (2013)
Caveolae and caveolin-1 (CAV1) have been linked to several cellular functions. However, a model explaining their roles in mammalian tissues in vivo is lacking. Unbiased expression profiling in several tissues and cell types identified lipid metabolis
Externí odkaz:
https://doaj.org/article/626b24aa557c4a558809186d6302745e
Autor:
John W. Funder, Colin Clyne, Morag J Young, Vanessa Cheung, Tram B. Doan, Peter J. Fuller, J. Dinny Graham, Christine L. Clarke, George E.O. Muscat, Heidi N. Hilton, Natalie A. Eriksson
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-16 (2020)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Background The role of nuclear receptors in both the aetiology and treatment of breast cancer is exemplified by the use of the oestrogen receptor (ER) as a prognostic marker and treatment target. Treatments targeting the oestrogen signalling pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62029ea50325ba6334b79412a0475355
http://link.springer.com/article/10.1186/s13058-020-01355-x
http://link.springer.com/article/10.1186/s13058-020-01355-x
Publikováno v:
Journal of Molecular Endocrinology. 62:R223-R237
Breast cancer is a heterogeneous disease, and the complexity of breast carcinogenesis is associated with epigenetic modification. There are several major classes of epigenetic enzymes that regulate chromatin activity. This review will focus on the ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ff5e6e8a8749688266ecf26f660f72
https://doi.org/10.1530/jme-18-0224
https://doi.org/10.1530/jme-18-0224
Autor:
George E.O. Muscat, Michael A. Pearen
Publikováno v:
Exercise and Sport Sciences Reviews. 46:97-104
Exercise induces various physical and metabolic changes in skeletal muscle that adaptively reprograms this tissue to current physiological and environmental demands. Underlying these changes are broad modifications to gene expression. We postulate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37dc3b9371dfa25306432132b4555448
https://doi.org/10.1249/jes.0000000000000143
https://doi.org/10.1249/jes.0000000000000143
Autor:
Sungmin Baek, Genevieve A. Secker, Katarzyna Koltowska, Anne K. Lagendijk, Scott Paterson, Natasha L. Harvey, Kelly A. Smith, Neil I. Bower, Samuel J. Capon, Drew L. Sutton, Kazuhide S. Okuda, Cas Simons, George E.O. Muscat, Tae Gyu Oh, Gregory J. Baillie, Benjamin M. Hogan, John Toubia
The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The first lymphatic vessels arise from pre-existing veins after venous endothelial cells become specified as lymphatic prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b507614e37d3f2099d04f26950609037
https://hdl.handle.net/11541.2/136969
https://hdl.handle.net/11541.2/136969
Autor:
Christine L. Clarke, Tae Gyu Oh, Bipul R. Acharya, Shu-Ching M. Wang, Alpha S. Yap, George E.O. Muscat, Joel M. Goode, J. Dinny Graham
Publikováno v:
EBioMedicine
We have previously reported that RORγ expression was decreased in ER − ve breast cancer, and increased expression improves clinical outcomes. However, the underlying RORγ dependent mechanisms that repress breast carcinogenesis have not been eluci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86c98b69ad939c06f1e7d510965e8e9
Autor:
Richard A. Sturm, Colin R. Goding, Nikolas K. Haass, Jagat Chauhan, David E.J. Hollingsworth, Mitchell Fane, Jacinta L. Simmons, Lachlan Harris, Loredana Spoerri, Tae Gyu Oh, Michael Piper, Glen M. Boyle, Yash Chhabra, George E.O. Muscat, Toby Chin, Tracey J. Harvey, Aaron G. Smith
Publikováno v:
EBioMedicine, Vol 16, Iss C, Pp 63-75 (2017)
EBioMedicine
EBioMedicine
While invasion and metastasis of tumour cells are the principle factor responsible for cancer related deaths, the mechanisms governing the process remain poorly defined. Moreover, phenotypic divergence of sub-populations of tumour cells is known to u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c28798ee31f67d50180e9869a79fea4
https://doi.org/10.1016/j.ebiom.2017.01.013
https://doi.org/10.1016/j.ebiom.2017.01.013
Autor:
Sean M. Grimmond, Christine L. Clarke, Aaron G. Smith, Peter J. Leedman, John W. Funder, Joel M. Goode, Peter Bailey, Wayne D. Tilley, Peter J. Fuller, George E.O. Muscat, Dennis H. Dowhan, Natalie A. Eriksson, Tae Gyu Oh, Evan R. Simpson, Eloise Dray
Publikováno v:
Molecular Endocrinology. 28:1166-1185
Protein arginine methyltransferases (PRMTs) methylate arginine residues on histones and target transcription factors that play critical roles in many cellular processes, including gene transcription, mRNA splicing, proliferation, and differentiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d82e5a93258241a3b0209c8fd6471b
https://doi.org/10.1210/me.2013-1403
https://doi.org/10.1210/me.2013-1403