Výsledky vyhledávání - "George E. Holmes"

Oxidative and other DNA damages as the basis of aging: a review

Autor: Carol Bernstein, George E. Holmes, Harris Bernstein

Publikováno v: Mutation Research/DNAging. 275:305-315

DNA damages occur continuously in cells of living organisms. While most of these damages are repaired, some accumulate. In particular, there is evidence for DNA damage accumulation in non-dividing cells of mammals. These accumulated DNA damages proba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a775fefa6d55b67b0826e2155b3a80d0
https://doi.org/10.1016/0921-8734(92)90034-m

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Accumulation of DNA damages in aging Paramecium tetraurelia

Autor: Norreen R. Holmes, George E. Holmes

Publikováno v: Molecular and General Genetics MGG. 204:108-114

Paramecium tetraurelia cells of ages 4, 15, and 27 days were labeled with [14C]-thymidine. In addition, cells were grown clonally for 27 days (108 generations) and labeled with [14C]-thymidine in the presence of 0.5 or 7.5 micrograms/ml of mitomycin-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff92cbdce649740924fc6fdcf00f2e4a
https://doi.org/10.1007/bf00330196

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Accumulation of DNA Fragments in Aging Paramecium tetraureliain Axenic and Nonaxenic Media

Autor: Norreen R. Holmes, George E. Holmes

Publikováno v: Gerontology. 32:252-260

The accumulation of DNA fragments in aging Paramecium tetraurelia after 15 days (or approximately 60 generations) of clonal growth in both axenic and nonaxenic media was assayed by alkaline elution assay. This sensitive technique permits measurement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64226a63b1747f98e87f0506ab08c71f
https://doi.org/10.1159/000212799

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The dependence of HNO2 mutagenesis in phage T4 on ligase and the lack of dependence of 2AP mutagenesis on repair functions

Autor: Silke Schneider, Helen L. Gensler, Don M. Morgan, Carol Bernstein, George E. Holmes

Publikováno v: Molecular and General Genetics MGG. 148:213-220

A temperature sensitive ligase allele of phage T4 reduced or eliminated HNO2 induced reversion of am mutants. Since at the temperatures used, the ligase mutant is defective in the repair of some types of lethal lesions (i.e., UV, MMS and EMS induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9a9118bda0829f1f55bb0a353ec8bd
https://doi.org/10.1007/bf00268387

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Intragenic Complementation by Gene 42 Amber Mutations of Bacteriophage T4

Autor: George E. Holmes

Publikováno v: Journal of Virology. 16:1085-1089

Phage T4 amber mutants defective in gene 42 (dCMP hydroxymethylase) were shown by in vivo and in vitro experiments to participate in both positive and negative intragenic complementation. This argues that incomplete polypeptide chains can participate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2713299ef72a11858f4595af0cbf228
https://doi.org/10.1128/jvi.16.4.1085-1089.1975

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THE EXCESS PROFITS TAX OF 1917: PART II

Autor: George E. Holmes

Publikováno v: The Bulletin of the National Tax Association. 4:39-46

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2d38f707bfdaabae3b9b2e82d0cab55
https://doi.org/10.1086/bullnattax41785253

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The Nature of Antibodies Following Experimental Arbovirus Infection in Guinea Pigs

Autor: Joseph A. Bellanti, Sudie B. Russ, George E. Holmes, Edward L. Buescher

Publikováno v: The Journal of Immunology. 94:1-11

Summary Following experimental infection of guinea pigs with Japanese encephalitis and Russian spring-summer encephalitis viruses, complement-fixing (CF), hemagglutination-inhibiting (HI) and neutralizing (N) antibodies are regularly formed by the 7t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65b3d9d9ad8ba15752451b9493ade7f6
https://doi.org/10.4049/jimmunol.94.1.1

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Suppression of phage nonsense and temperature-sensitive mutants by an suA mutant E. coli

Autor: George E. Holmes

Publikováno v: Nature. 250:73-75

BECKWITH and Scaife1,2 showed that the suppressor allele suA of Escherichia coli does not suppress nonsense codons in the lactose operon, but does relieve the polarity effect of UAG, UAA and possibly frameshift mutations. It is shown here that suA E.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099176253cf8424f1b37c60ba55d8638
https://doi.org/10.1038/250073a0

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Recombinational repair of mitomycin C lesions in phage T4

Autor: George E. Holmes, Silke Schneider, Carol Bernstein, Harris Bernstein

Publikováno v: Virology. 103(2)

Treatment of phage T4-host adsorption complexes with mitomycin C (MMC) doubled the frequency of recombination between two r II markers. The rate at which MMC delivered lethal lesions to cells infected by two or more phage (multicomplexes) was 10-fold

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519ecaaf66552ea4c3e4c8c60721f525
https://pubmed.ncbi.nlm.nih.gov/6930130

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