Estimation of the Minimal Rift Valley Fever Virus Protective Neutralizing Antibody Titer in Human Volunteers Immunized with MP-12 Vaccine Based on Protection in a Mouse Model of Disease

Autor: Douglas M. Watts, Jonna L.B. Westover, Pedro M. Palermo, Kevin W. Bailey, John C. Morrill, George E. Bettinger, Thomas P. Monath, Darci R. Smith, Clarence J. Peters, Phillip R. Pittman, Jeanette Orbegozo, Brian B. Gowen

Publikováno v: The American journal of tropical medicine and hygiene. 107(5)

The Rift Valley fever virus (RVFV) MP-12 vaccine is a promising human and veterinary vaccine. Although the vaccine elicited neutralizing antibody (nAb) in human volunteers, the minimal antibody titer that is needed to afford protection is unknown. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533658f5dd6fe1e73d0e061def07355c
https://pubmed.ncbi.nlm.nih.gov/36122681

Safety and immunogenicity of Rift Valley fever MP-12 and arMP-12ΔNSm21/384 vaccine candidates in goats (Capra aegagrus hircus) from Tanzania

Autor: Jessica Rowland, Philemon N. Wambura, Mirende Kichuki Matiko, Pedro M. Palermo, Salama Nyundo, Ester Adamson, Douglas M. Watts, George E Bettinger, John C. Morrill

Publikováno v: Onderstepoort Journal of Veterinary Research, Volume: 86, Issue: 1, Pages: 1-8, Published: 2019
The Onderstepoort Journal of Veterinary Research
Onderstepoort Journal of Veterinary Research, Vol 86, Iss 1, Pp e1-e8 (2019)

Vaccination of domestic ruminants is considered to be an effective strategy for protecting these animals against Rift Valley fever (RVF), but available vaccines have limitations. Therefore, the aim of this study was to determine the safety and immuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949ce6b99c5731d28574af316309fb5f
https://doi.org/10.4102/ojvr.v86i1.1683

Efficacy of a recombinant Rift Valley fever virus MP-12 with NSm deletion as a vaccine candidate in sheep

Autor: Peter Marszal, John C. Morrill, Shunzhen Zhang, William C. Wilson, Hana M. Weingartl, C. J. Peters, George E. Bettinger, Charles Nfon

Publikováno v: Vaccine. 32(20)

Rift Valley fever virus (RVFV), a mosquito-borne virus in the Bunyaviridae family and Phlebovirus genus, causes RVF, a disease of ruminants and man, endemic in Sub-Saharan African countries. However, outbreaks in Yemen and Saudi Arabia demonstrate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9b3b5e2e1d123929bdb4cb7ce3f71c
https://pubmed.ncbi.nlm.nih.gov/24462482

Evidence for the extrusion of an incompletely folded form of penicillinase during secretion by protoplasts of bacillus licheniformis 749/C1

Autor: George E. Bettinger, J.O. Lampen

Publikováno v: Biochemical and Biophysical Research Communications. 43:200-206

Summary The cell-bound and exocellular penicillinases of B. licheniformis 749/C are resistant to trypsin and chymotrypsin. The production of penicillinase sensitive to these proteases has been detected utilizing protoplasts stripped of part of their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8be263de0a578389448c7da37bf02951
https://doi.org/10.1016/s0006-291x(71)80107-9

Tunicamycin, an inhibitor of Bacillus peptidoglycan synthesis: a new site of inhibition

Autor: Frank E. Young, George E. Bettinger

Publikováno v: Biochemical and biophysical research communications. 67(1)

Bacillus subtilis membranes can transfer either N-acetylmuramyl-pentapeptide phosphate or N-acetylglucosaminyl phosphate from UMP directly onto undecaprenyl phosphate. Tunicamycin blocks only the latter transfer and inhibits peptidoglycan synthesis b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f77d0cb342e2ba952a9f9e2a17c504f
https://pubmed.ncbi.nlm.nih.gov/812492