Zobrazeno 1 - 10
of 276
pro vyhledávání: '"George E Wright"'
Autor:
Hung Chang, Ivan B Yanachkov, Edward J Dix, Milka Yanachkova, Youfu Li, Marc R Barnard, George E Wright, Alan D Michelson, Andrew L Frelinger
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94780 (2014)
Diadenosine tetraphosphate (Ap4A), a constituent of platelet dense granules, and its P1,P4-dithio and/or P2,P3-chloromethylene analogs, inhibit adenosine diphosphate (ADP)-induced platelet aggregation. We recently reported that these compounds antago
Externí odkaz:
https://doaj.org/article/874ef7e91dfb4fdb80321881bbbe4d83
Autor:
Dean Bryant, George E. Wright, James S. Blachly, Jonathan C. Strefford, Graham Packham, Carl G. Figdor, Francesco Forconi, Isla Henderson, Thomas A. Bowden, Giorgia Chiodin, Teunis B. H. Geijtenbeek, Beatriz Valle-Argos, Philip J. Rock, Enrica Antonia Martino, Patrick J. Duriez, Freda K. Stevenson, Yasunori Watanabe, Katy J. McCann, Louis M. Staudt, Max Crispin, Joel D. Allen, Richard Burack
Publikováno v:
Blood, 138(17), 1570-1582. American Society of Hematology
Blood, 138, 17, pp. 1570-1582
Blood, 138, 1570-1582
Blood
Blood, 138, 17, pp. 1570-1582
Blood, 138, 1570-1582
Blood
Glycosylation of the surface immunoglobulin (Ig) variable region is a remarkable follicular lymphoma–associated feature rarely seen in normal B cells. Here, we define a subset of diffuse large B-cell lymphomas (DLBCLs) that acquire N-glycosylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29c1bc1823f404e2a7f19678b1ca290
https://hdl.handle.net/2066/244632
https://hdl.handle.net/2066/244632
Autor:
Louis M. Staudt, Carmen Doebele, Hang Nguyen, Arthur L. Shaffer, Angelika Oellerich, Yanlong Ji, Thomas Oellerich, George E. Wright, Samantha Schaller, Sebastian Scheich, Richard Longnecker, Jagan R. Muppidi, Kuan-Ting Pan, Henning Urlaub, Kamonwan Fish, Hubert Serve, Federico Comoglio, Masato Ikeda
Publikováno v:
Proc Natl Acad Sci U S A
Epstein-Barr virus (EBV) infects human B cells and reprograms them to allow virus replication and persistence. One key viral factor in this process is latent membrane protein 2A (LMP2A), which has been described as a B cell receptor (BCR) mimic promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf1bf5c332e99ab65fc5b621d6e908d
https://doi.org/10.1073/pnas.2007946117
https://doi.org/10.1073/pnas.2007946117
Autor:
Louis M. Staudt, Christopher Melani, Da-Wei Huang, Alina Nicolae, Stefania Pittaluga, Seth M. Steinberg, George E. Wright, Elaine S. Jaffe, Wyndham H. Wilson, Mark Roschewski
Publikováno v:
Blood Cancer Discov
Mediastinal gray zone lymphoma (MGZL) has immunopathologic features between classical Hodgkin lymphoma (cHL) and primary mediastinal thymic B-cell lymphoma (PMBL), leading to uncertainty regarding its biological relationship to these entities. We per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2d7fa503e27ffc6afffd2b2b9ca700
https://doi.org/10.1158/2643-3230.bcd-20-0009
https://doi.org/10.1158/2643-3230.bcd-20-0009
Publikováno v:
Comparative Medicine. 70:56-66
Zoonotic monkey B virus (Macacine alphaherpesvirus 1; BV) infections are extremely serious and usually fatal. Drugs currently used for treatment were developed for the treatment of herpes simplex virus but are less effective against BV. Effective sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::138c36acbc39e589ec3229252261e3ee
https://doi.org/10.30802/aalas-cm-18-000134
https://doi.org/10.30802/aalas-cm-18-000134
Autor:
Frances A. Tosto, Ping Chen, Dickran Kazandjian, Craig J. Thomas, George E. Wright, Kelli M. Wilson, Thomas Oellerich, James W. Lord, Carleen Klumpp-Thomas, Irina Maric, Grace Smith, Crystal McKnight, Da-Wei Huang, Jan Wisnieski, Xin Yu, Ryan M. Young, Björn Häupl, Michele Ceribelli, Arnold Bolomsky, James Q. Wang, Erin S Beck, Callie K. Van Winkle, Jameson Travers, James D. Phelan, Stefania Pittaluga, Yandan Yang
Publikováno v:
Nature communications. 13(1)
Oncogenic mutations within the RAS pathway are common in multiple myeloma (MM), an incurable malignancy of plasma cells. However, the mechanisms of pathogenic RAS signaling in this disease remain enigmatic and difficult to inhibit therapeutically. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ff65735fce3a50eebd3af3c1317c4c
https://pubmed.ncbi.nlm.nih.gov/36192480
https://pubmed.ncbi.nlm.nih.gov/36192480
Autor:
Michael C. Kelly, Xiaohu Zhang, Kelli M. Wilson, Erika M Gaglione, Inhye E. Ahn, Zachary Rae, Lu Chen, Louis M. Staudt, Weihong Xu, Yandan Yang, James D. Phelan, Sandrine Roulland, Dan E. Webster, Arthur L. Shaffer, Björn Häupl, Hong Zhao, Xin Yu, Clare Sun, George E. Wright, Jaewoo Choi, Crystal McKnight, Da-Wei Huang, Craig J. Thomas, Ryan M. Young, Monica Kasbekar, James Q. Wang, Thomas Oellerich, Wyndham H. Wilson, Carleen Klumpp-Thomas, Adrian Wiestner, Michele Ceribelli
Publikováno v:
Blood Cancer Discov
The use of Bruton tyrosine kinase (BTK) inhibitors to block B-cell receptor (BCR)–dependent NF-κB activation in lymphoid malignancies has been a major clinical advance, yet acquired therapeutic resistance is a recurring problem. We modeled the dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac385850371cd627d809df8da7e0a54
https://europepmc.org/articles/PMC8580621/
https://europepmc.org/articles/PMC8580621/
Autor:
Louis M. Staudt, Roland Schmitz, Thomas Oellerich, Wyndham H. Wilson, George E. Wright, Ryan M. Young, James D. Phelan, Calvin A. Johnson, Arthur L. Shaffer, Da-Wei Huang
Publikováno v:
Annual Review of Cancer Biology. 3:429-455
Genomic analyses of diffuse large B cell lymphoma (DLBCL) are revealing the genetic and phenotypic heterogeneity of these aggressive lymphomas. In part, this heterogeneity reflects the existence of distinct genetic subtypes that acquire characteristi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3524482ab237561010f5a33a1d723e7d
https://doi.org/10.1146/annurev-cancerbio-030518-055734
https://doi.org/10.1146/annurev-cancerbio-030518-055734
Autor:
Brendan Hodkinson, Louis M. Staudt, George E. Wright, Martin Shreeve, Sriram Balasubramanian, Yue Fan, Wyndham H. Wilson, Da-Wei Huang, Jessica Vermeulen
Publikováno v:
Cancer cell. 39(12)
Summary In diffuse large B cell lymphoma (DLBCL), tumors belonging to the ABC but not GCB gene expression subgroup rely upon chronic active B cell receptor signaling for viability, a dependency that is targetable by ibrutinib. A phase III trial (“P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d5e7b3ce7a2fb5c648b8241c56ed7e
https://pubmed.ncbi.nlm.nih.gov/34739842
https://pubmed.ncbi.nlm.nih.gov/34739842
Autor:
Louis M. Staudt, Amy S. Kimball, Sven de Vos, Jerry Ping, Darrin M. Beaupre, Wyndham H. Wilson, Da-Wei Huang, Kevin A. Kwei, George E. Wright, Leslie Popplewell, Jutta K. Neuenburg, Saurabh Chhabra, Tycel Phillips
Publikováno v:
Leukemialymphoma. 62(9)
Relapsed/refractory diffuse large B-cell lymphoma (DLBCL) is difficult to cure; non-germinal center B-cell-like (non-GCB) and activated B-cell-like (ABC) DLBCL have worse outcomes than GCB DLBCL. Ibrutinib and lenalidomide are synergistic in vitro in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fb6284c7912a55b4aa5b029c255205
https://pubmed.ncbi.nlm.nih.gov/33856277
https://pubmed.ncbi.nlm.nih.gov/33856277