Zobrazeno 1 - 10
of 251
pro vyhledávání: '"George E Davis"'
Autor:
Jennifer A Schumacher, Zoë A Wright, Diandra Rufin Florat, Surendra K Anand, Manish Dasyani, Surya Prakash Rao Batta, Valentina Laverde, Kaitlin Ferrari, Laurita Klimkaite, Nina O Bredemeier, Suman Gurung, Gretchen M Koller, Kalia N Aguera, Griffin P Chadwick, Riley D Johnson, George E Davis, Saulius Sumanas
Publikováno v:
PLoS Genetics, Vol 20, Iss 1, p e1010851 (2024)
Blood vessels in different vascular beds vary in size, which is essential for their function and fluid flow along the vascular network. Molecular mechanisms involved in the formation of a vascular lumen of appropriate size, or tubulogenesis, are stil
Externí odkaz:
https://doaj.org/article/19690feb94b046cf83ff5f524a60d51c
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0235116 (2020)
Here, we examine known GTPase regulators of vesicle trafficking events to assess whether they affect endothelial cell (EC) lumen and tube formation. We identify novel roles for the small GTPases Rab3A, Rab3B, Rab8A, Rab11A, Rab27A, RalA, RalB and cav
Externí odkaz:
https://doaj.org/article/052610860756455f90d2eb79691c312b
Autor:
Dae Joong Kim, Pieter R Norden, Jocelynda Salvador, David M Barry, Stephanie L K Bowers, Ondine Cleaver, George E Davis
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184461 (2017)
Here we examine the question of how endothelial cells (ECs) develop their apical membrane surface domain during lumen and tube formation. We demonstrate marked apical membrane targeting of activated Src kinases to this apical domain during early and
Externí odkaz:
https://doaj.org/article/f1a989f8e0584da284439abdd48c2c64
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147758 (2016)
A critical and understudied property of endothelial cells is their ability to form lumens and tube networks. Although considerable information has been obtained concerning these issues, including the role of Cdc42 and Rac1 and their effectors such as
Externí odkaz:
https://doaj.org/article/c4dfb27c6a0e4696806afecdeb899000
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e85147 (2013)
We describe a novel 3D fibrin matrix model using recombinant hematopoietic stem cell cytokines under serum-free defined conditions which promotes the assembly of human endothelial cell (EC) tubes with co-associated pericytes. Individual ECs and peric
Externí odkaz:
https://doaj.org/article/270db60ce53347f49d8813b64634a364
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: We sought to determine how endothelial cell (EC) expression of the activating k-Ras (kirsten rat sarcoma 2 viral oncogene homolog) mutation, k-RasV12, affects their ability to form lumens and tubes and interact with pericytes during capill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b6b5e03c31355c8e9f2b25570e3176
https://doi.org/10.1161/atvbaha.121.316798
https://doi.org/10.1161/atvbaha.121.316798
Autor:
Gretchen M. Koller, George E. Davis, Kalia N. Aguera, Scott S. Kemp, Prisca K. Lin, Courtney T. Griffin, Jun Xie, Jocelynda Salvador
Publikováno v:
Am J Pathol
Whether alterations in the microtubule cytoskeleton affect the ability of endothelial cells (ECs) to sprout and form branching networks of tubes was investigated in this study. Bioassays of human EC tubulogenesis, where both sprouting behavior and lu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aabec95afdeb9f924c3ea83f6b32c01
https://doi.org/10.1016/j.ajpath.2021.08.017
https://doi.org/10.1016/j.ajpath.2021.08.017
Autor:
George E. Davis, Scott S. Kemp
Publikováno v:
Cold Spring Harbor perspectives in medicine.
The extracellular matrix represents a critical regulator of tissue vascularization during embryonic development and postnatal life. In this perspective, we present key information and concepts that focus on how the extracellular matrix controls capil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339fcfc1a7a28e65367d40068b379a02
https://pubmed.ncbi.nlm.nih.gov/35817544
https://pubmed.ncbi.nlm.nih.gov/35817544
Autor:
Gretchen M. Koller, George E. Davis, Joshua C. Forgy, Stephanie L.K. Bowers, Kalia N. Aguera, Scott S. Kemp
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 40:2891-2909
Objective: In this work, we have sought to define growth factor requirements and the signaling basis for different stages of human vascular morphogenesis and maturation. Approach and Results: Using a serum-free model of endothelial cell (EC) tube mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::937229e9f60ecc4696448de949a988d6
https://doi.org/10.1161/atvbaha.120.314517
https://doi.org/10.1161/atvbaha.120.314517
Autor:
Scott S. Kemp, Prisca K. Lin, Zheying Sun, Maria A. Castaño, Ksenia Yrigoin, Marlena R. Penn, George E. Davis
Publikováno v:
Frontiers in cell and developmental biology. 10
Here we address the functional importance and role of pericytes in capillary tube network assembly, an essential process that is required for vascularized tissue development, maintenance, and health. Healthy capillaries may be directly capable of sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf9cb001fff84b3de3a631061960d27
https://pubmed.ncbi.nlm.nih.gov/36072343
https://pubmed.ncbi.nlm.nih.gov/36072343