Zobrazeno 1 - 10
of 16
pro vyhledávání: '"George Delidakis"'
Autor:
Chang-Han Lee, Tae Hyun Kang, Ophélie Godon, Makiko Watanabe, George Delidakis, Caitlin M. Gillis, Delphine Sterlin, David Hardy, Michel Cogné, Lynn E. Macdonald, Andrew J. Murphy, Naxin Tu, Jiwon Lee, Jonathan R. McDaniel, Emily Makowski, Peter M. Tessier, Aaron S. Meyer, Pierre Bruhns, George Georgiou
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Lee et al. report an engineered IgG1 Fc domain that behaves like an hFcRn binding pH toggle switch. The authors show that this new half-life extension Fc domain confers improved pharmacokinetics in new humanized knock-in mouse strains that recapitula
Externí odkaz:
https://doaj.org/article/84d23b07351d4847b7e49dca2fbb568c
Autor:
Tae Hyun Kang, Chang-Han Lee, George Delidakis, Jiwon Jung, Odile Richard-Le Goff, Jiwon Lee, Jin Eyun Kim, Wissam Charab, Pierre Bruhns, George Georgiou
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
IgG antibodies mediate the clearance of target cells via the engagement of Fc gamma receptors (FcγRs) on effector cells by eliciting antibody-dependent cellular cytotoxicity and phagocytosis (ADCC and ADCP, respectively). Because (i) the IgG Fc doma
Externí odkaz:
https://doaj.org/article/14736d77c6ce439ba0931b0ea86ecb01
Autor:
Chang-Han Lee, Tae Hyun Kang, Ophélie Godon, Makiko Watanabe, George Delidakis, Caitlin M. Gillis, Delphine Sterlin, David Hardy, Michel Cogné, Lynn E. Macdonald, Andrew J. Murphy, Naxin Tu, Jiwon Lee, Jonathan R. McDaniel, Emily Makowski, Peter M. Tessier, Aaron S. Meyer, Pierre Bruhns, George Georgiou
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/8c4e20eedae3439a812a8b79401a3610
Autor:
Lori A. Rowe, Ilya J. Finkelstein, Kamyab Javanmardi, Daniel R. Boutz, Jin Eyun Kim, Shivaprakash Gangappa, Jonathan R. McDaniel, Ralph S. Baric, Dhwani Batra, Maria D. Person, George Georgiou, William N. Voss, Brent L. Iverson, Gregory C. Ippolito, Katia George, Andrew S. Herbert, Yuri Tanno, Foteini Bartzoka, Shawn A. Abbasi, Jason S. McLellan, Jimmy Gollihar, Suryaprakash Sambhara, Daniel Billick, Jule Goike, Chelsea J. Paresi, Whitney Pickens, George Delidakis, Justin S. Lee, Nicole V. Johnson, Yixuan J. Hou, Nianshuang Wang, Andrew P. Horton, Jason J. Lavinder, Jan Pohl, Michelle Gadush, Chia Wei Chou, John M. Dye, Dalton M Towers
Publikováno v:
bioRxiv
Although humoral immunity is essential for control of SARS-CoV-2, the molecular composition, binding epitopes and effector functions of the immunoglobulin G (IgG) antibodies that circulate in blood plasma following infection are unknown. Proteomic de
Autor:
Chang-Han Lee, George Delidakis
Publikováno v:
Methods in Molecular Biology ISBN: 9781071619438
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09ad9fbea3d8b231af06302ee913d139
https://doi.org/10.1007/978-1-0716-1944-5_13
https://doi.org/10.1007/978-1-0716-1944-5_13
Autor:
Chang-Han, Lee, George, Delidakis
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2421
Fc-mediated effector functions are important for the clearance of pathologic cells by therapeutic IgG antibodies through two mechanisms: via the activation of the classical complement pathway and through the binding to Fcγ receptors (FcγRs) which m
Autor:
Annalee W. Nguyen, Christopher A. Stevens, Ellen K. Wagner, George Delidakis, Ahlam Qerqez, Jennifer A. Maynard
Publikováno v:
Journal of Biological Chemistry. 294:5790-5804
T-cell receptors (TCR) have considerable potential as therapeutics and antibody-like reagents to monitor disease progression and vaccine efficacy. Whereas antibodies recognize only secreted and surface-bound proteins, TCRs recognize otherwise inacces
Autor:
Yixuan J. Hou, Daniel Billick, Shivaprakash Gangappa, Jason S. McLellan, Lori A. Rowe, Jonathan R. McDaniel, Brent L. Iverson, Dhwani Batra, Chelsea J. Paresi, Nicole V. Johnson, Shawn A. Abbasi, Michelle Gadush, Andrew S. Herbert, Jimmy Gollihar, Ralph S. Baric, Gregory C. Ippolito, Foteini Bartzoka, Andrew P. Horton, George Georgiou, William N. Voss, Yuri Tanno, Jan Pohl, George Delidakis, John M. Dye, Whitney Pickens, Dalton M Towers, Suryaprakash Sambhara, Justin S. Lee, Nianshuang Wang, Jason J. Lavinder, Jule Goike, Daniel R. Boutz, Jin Eyun Kim, Katia George, Maria D. Person
Publikováno v:
Science (New York, N.y.)
SUMMARYAlthough humoral immunity is essential for control of SARS-CoV-2, the molecular composition, binding epitopes and effector functions of the immunoglobulin G (IgG) antibodies that circulate in blood plasma following infection are unknown. Prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a594216b5cb4ab9e788a3418165d91b2
https://doi.org/10.1101/2020.12.20.423708
https://doi.org/10.1101/2020.12.20.423708
Autor:
Macdonald Lynn, Michel Cogné, Andrew J. Murphy, Pierre Bruhns, Tae Hyun Kang, Makiko Watanabe, George Georgiou, Chang-Han Lee, Delphine Sterlin, David Hardy, Ophélie Godon, Peter M. Tessier, Jonathan R. McDaniel, George Delidakis, Caitlin M. Gillis, Aaron S. Meyer, Emily K. Makowski, Naxin Tu, Jiwon Lee
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.5031. ⟨10.1038/s41467-019-13108-2⟩
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature communications, vol 10, iss 1
Nature Communications, 2019, 10 (1), pp.5031. ⟨10.1038/s41467-019-13108-2⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.5031. ⟨10.1038/s41467-019-13108-2⟩
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature communications, vol 10, iss 1
Nature Communications, 2019, 10 (1), pp.5031. ⟨10.1038/s41467-019-13108-2⟩
The pharmacokinetic properties of antibodies are largely dictated by the pH-dependent binding of the IgG fragment crystallizable (Fc) domain to the human neonatal Fc receptor (hFcRn). Engineered Fc domains that confer a longer circulation half-life b
Autor:
Ophélie Godon, Macdonald Lynn, Makiko Watanabe, George Georgiou, Peter M. Tessier, Andrew J. Murphy, Michel Cogné, David Hardy, Emily K. Makowski, Chang-Han Lee, Delphine Sterlin, George Delidakis, Caitlin M. Gillis, Aaron S. Meyer, Jonathan R. McDaniel, Jiwon Lee, Tae Hyun Kang, Pierre Bruhns, Naxin Tu
Publikováno v:
Nature communications, vol 10, iss 1
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
The pharmacokinetic properties of antibodies are largely dictated by the pH-dependent binding of the IgG fragment crystallizable (Fc) domain to the human neonatal Fc receptor (hFcRn). Engineered Fc domains that confer a longer circulation half-life b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5da5c7a3dc1f5ac7546b6627778cb8b
https://escholarship.org/uc/item/7x73k9v5
https://escholarship.org/uc/item/7x73k9v5