Zobrazeno 1 - 10
of 35
pro vyhledávání: '"George D. Maynard"'
Autor:
William B. J. Cafferty, Xingxing Wang, Stephen M. Strittmatter, Tianna Zhou, George D. Maynard, Jeffery D. Kocsis, Pramod S Terse
Publikováno v:
Brain
After CNS trauma such as spinal cord injury, the ability of surviving neural elements to sprout axons, reorganize neural networks and support recovery of function is severely restricted, contributing to chronic neurological deficits. Among limitation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2122ea96e4494f221d54a29008e268f
https://doi.org/10.1093/brain/awaa116
https://doi.org/10.1093/brain/awaa116
Autor:
Mulugeta Million, Jing-Fang Zhao, Andrew Luckey, József Czimmer, George D Maynard, John Kehne, Diane C Hoffman, Yvette Taché
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73749 (2013)
Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related body responses. However to date there are no CRF1 antagonists that have shown clinical efficacy in stress-related diseases. We investigated the inhibito
Externí odkaz:
https://doaj.org/article/803ea8aaa29b44e9b54bec8f43f6b2fd
Autor:
Jun Lin, Eric Frieden, Ajay Bhargava, James C. Tsai, Stephen M. Strittmatter, Xingxing Wang, Juliann Boccio, Alexander Arzeno, George D. Maynard, Jin-Young Choi
Publikováno v:
Investigative Ophthalmology & Visual Science. 56:1357-1366
Purpose Glaucoma is a major cause of vision loss due to retinal ganglion cell (RGC) degeneration. Therapeutic intervention controls increased IOP, but neuroprotection is unavailable. NogoReceptor1 (NgR1) limits adult central nervous system (CNS) axon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c594e1146650efb0dd4e4979f6d0c1e
https://doi.org/10.1167/iovs.14-15472
https://doi.org/10.1167/iovs.14-15472
Autor:
John H. Kehne, George D. Maynard
Publikováno v:
Targets and Emerging Therapies for Schizophrenia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7742045f376a193b19ec7574597fdef
https://doi.org/10.1002/9781118309421.ch15
https://doi.org/10.1002/9781118309421.ch15
Autor:
John H. Kehne, George D. Maynard
Publikováno v:
Drug Discovery Today: Therapeutic Strategies. 5:161-168
Adaptive responding to stressors is of fundamental importance to the survival of the species. Aberrant hyperactivation of corticotropin releasing factor type 1 (CRF1) receptors in dysfunctional stress response system (SRS) pathways may contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1146b0be39421521956f717fa7dfd3b0
https://doi.org/10.1016/j.ddstr.2008.09.003
https://doi.org/10.1016/j.ddstr.2008.09.003
Autor:
Zhe-Qing Wang, Bertrand L. Chenard, Bingsong Han, George D. Maynard, Yuelian Xu, Kenneth R. Shaw, Linghong Xie
Publikováno v:
Organic Process Research & Development. 11:716-720
A scaleable route to 6-chloro-4-[2-(3-fluoropyridin-2-yl)-imidazol-1-ylmethyl]-5-propyl-pyrimidine (NDT 9533750), a key intermediate to a series of novel subtype preferring GABAA partial agonists, is described in which various scaleup issues were add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abd054a674a526cd24ffa95ce730ac27
https://doi.org/10.1021/op700084h
https://doi.org/10.1021/op700084h
Autor:
Xingxing Wang, Eric Frieden, William B. J. Cafferty, George D. Maynard, Stephen M. Strittmatter, Chang-Yeon Kim, Dana Wirak, Kazim Yigitkanli, Ajay Bhargava, Tomoko Sekine-Komo
Axonal growth and neurological recovery after traumatic spinal cord injury (SCI) is limited by the presence of inhibitory proteins in myelin, several of which act via the NgR1 protein in neurons. A truncated soluble ligand-binding fragment of NgR1 se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c66b7db1a92595523f3f32dbbfb569e
https://europepmc.org/articles/PMC4245872/
https://europepmc.org/articles/PMC4245872/
Publikováno v:
Expert opinion on investigational drugs. 21(9)
Post-traumatic stress disorder (PTSD) is a chronic debilitating psychiatric disorder resulting from exposure to a severe traumatic stressor and an area of great unmet medical need. Advances in pharmacological treatments beyond the currently approved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e17da43426bdefbbd9b2983a6b6f8aa
https://pubmed.ncbi.nlm.nih.gov/22834476
https://pubmed.ncbi.nlm.nih.gov/22834476