Zobrazeno 1 - 10
of 89
pro vyhledávání: '"George D. D. Jones"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7195 (2023)
Numerous studies have demonstrated the normal tissue-sparing effects of ultra-high dose rate ‘FLASH’ irradiation in vivo, with an associated reduction in damage burden being reported in vitro. Towards this, two key radiochemical mechanisms have b
Externí odkaz:
https://doaj.org/article/42819bda25fd48edb6d3709adee9ced4
Autor:
Hussein H. K. Abbas, Kheloud M. H. Alhamoudi, Mark D. Evans, George D. D. Jones, Steven S. Foster
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-15 (2018)
Abstract Background Targeted therapies are based on exploiting cancer-cell-specific genetic features or phenotypic traits to selectively kill cancer cells while leaving normal cells unaffected. Oxidative stress is a cancer hallmark phenotype. Given t
Externí odkaz:
https://doaj.org/article/57432eb1a9e44b4180fba3c67aee2427
Autor:
Alaa S. Alhegaili, Yunhee Ji, Nicolas Sylvius, Matthew J. Blades, Mahsa Karbaschi, Helen G. Tempest, George D. D. Jones, Marcus S. Cooke
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 20, p 5112 (2019)
The distribution of DNA damage and repair is considered to occur heterogeneously across the genome. However, commonly available techniques, such as the alkaline comet assay or HPLC-MS/MS, measure global genome levels of DNA damage, and do not reflect
Externí odkaz:
https://doaj.org/article/61f9325613a24f4fb15d737bd59ce0e1
Autor:
George D. D. Jones, Mark D. Farrar, Marcus S. Cooke, Chiung-Wen Hu, Barbara Shih, Lesley E. Rhodes, Mu-Rong Chao, Donald Allan, Andy Vail
Publikováno v:
Free Radical Biology & Medicine
Skin melanisation ranges widely across human populations. Melanin has antioxidant properties and also acts as a filter to solar ultraviolet radiation (UVR) incident upon the skin. In this study we firstly examined whether melanin level might influenc
Autor:
George D. D. Jones, P. Symonds
Publikováno v:
Clinical Oncology. 31:269-271
Autor:
P. Symonds, George D. D. Jones
Publikováno v:
Clinical oncology (Royal College of Radiologists (Great Britain)). 31(7)
FLASH radiotherapy (FLASH-RT) is a technology that could modify the way radiotherapy is delivered in the future. This technique involves the ultra-fast delivery of radiotherapy at dose rates several orders of magnitude higher than those currently use
Publikováno v:
Clinical oncology (Royal College of Radiologists (Great Britain)). 31(5)
Radiotherapy is still a treatment of choice for many malignancies, often in combination with other strategies. However, its efficacy is limited by the dose that can be safely administered without eliciting serious side-effects, as well as the fact th
Autor:
Paul Symonds, George D. D. Jones
Publikováno v:
Clinical Oncology. 32:479
Autor:
Larissa Lezina, George D. D. Jones, Ruth V. Spriggs, Simon D. Wagner, Anne E. Willis, Carolyn J.P. Jones, Kate Dudek, Daniel O. Beck, Aleksandra Bzura, Graham Packham
CD40L/interleukin-4 (IL-4) stimulation occurs in vivo in the tumor microenvironment and induces global translation to varying degrees in individuals with chronic lymphocytic leukemia (CLL) in vitro. However, the implications of CD40L/IL-4 for the tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c9881dd793a18543057a6e3a63406e
https://eprints.soton.ac.uk/423934/
https://eprints.soton.ac.uk/423934/
Autor:
Joanna P. Wood, Barry L. Sharp, Helen J. Reid, Sarah Taylor, George D. D. Jones, Anne L. Thomas
Publikováno v:
Analytical and Bioanalytical Chemistry. 406:8033-8036
This note presents a comparison of the use of saliva versus leukocytes for the determination of Pt-DNA adducts obtained from patients undergoing platinum-based chemotherapy. Samples of both blood and saliva were taken pre- and post-treatment and were