Zobrazeno 1 - 10
of 47
pro vyhledávání: '"George D Kalliolias"'
Autor:
Konstantinos Loupasakis, David Kuo, Upneet K Sokhi, Christopher Sohn, Bethany Syracuse, Eugenia G Giannopoulou, Sung Ho Park, Hyelim Kang, Gunnar Rätsch, Lionel B Ivashkiv, George D Kalliolias
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0179762 (2017)
During rheumatoid arthritis (RA), Tumor Necrosis Factor (TNF) activates fibroblast-like synoviocytes (FLS) inducing in a temporal order a constellation of genes, which perpetuate synovial inflammation. Although the molecular mechanisms regulating TNF
Externí odkaz:
https://doaj.org/article/fc2e2852a93d4ad5bf6d724ad55ed4d1
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-4 (2024)
Abstract With great interest, we have read the recent article “Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery” published by Lyu et al. in Annals of the Rheumatic Dis
Externí odkaz:
https://doaj.org/article/4f9ef201e7504681b3f9d058752051d1
Publikováno v:
Pharmacological Research, Vol 210, Iss , Pp 107537- (2024)
Externí odkaz:
https://doaj.org/article/70cd9ac076e64113852e003d6a37dc78
Autor:
Bei Wang, Jacquelynn Golubov, Erin M. Oswald, Patrick Poon, Qiaozhi Wei, Clarissa Lett, Fadi Shehadeh, Matthew Kaczynski, Lewis Oscar Felix, Biswajit Mishra, Evangelia K. Mylona, Matthew F. Wipperman, Erica Chio, Sara C. Hamon, Andrea T. Hooper, Selin Somersan-Karakaya, Bret J. Musser, Christopher D. Petro, Jennifer D. Hamilton, Matthew A. Sleeman, George D. Kalliolias, Eleftherios Mylonakis, Dimitris Skokos
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105334- (2024)
Summary: Background: Passive administration of SARS-CoV-2 neutralizing monoclonal antibodies (mAbs), such as CAS + IMD (Casirivimab + Imdevimab) antibody cocktail demonstrated beneficial effects on clinical outcomes in hospitalized patients with COVI
Externí odkaz:
https://doaj.org/article/2b0af8e604764c0bbe87f262c39423c8
Targeting TLR Signaling Cascades in Systemic Lupus Erythematosus and Rheumatoid Arthritis: An Update
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 138 (2024)
Evidence from animal models and human genetics implicates Toll-like Receptors (TLRs) in the pathogenesis of Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). Endosomal TLRs sensing nucleic acids were proposed to induce lupus-promoting
Externí odkaz:
https://doaj.org/article/f0fee9a00f4d40208050b4e0b3ac84a6
Autor:
Matthew P. Kosloski, George D. Kalliolias, Christine R. Xu, Sivan Harel, Ching‐Ha Lai, Wenjun Zheng, John D. Davis, Mohamed A. Kamal
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 2, Pp 384-395 (2022)
Abstract Itepekimab is a monoclonal antibody that targets interleukin (IL‐33) and has been shown to reduce airway inflammation and associated tissue damage in preclinical studies. We assessed the safety, tolerability, pharmacokinetics (PKs), and ph
Externí odkaz:
https://doaj.org/article/feb1920e777547ffb5e5c23f8ef174ce
Autor:
Fumitaka Mizoguchi, Kamil Slowikowski, Kevin Wei, Jennifer L. Marshall, Deepak A. Rao, Sook Kyung Chang, Hung N. Nguyen, Erika H. Noss, Jason D. Turner, Brandon E. Earp, Philip E. Blazar, John Wright, Barry P. Simmons, Laura T. Donlin, George D. Kalliolias, Susan M. Goodman, Vivian P. Bykerk, Lionel B. Ivashkiv, James A. Lederer, Nir Hacohen, Peter A. Nigrovic, Andrew Filer, Christopher D. Buckley, Soumya Raychaudhuri, Michael B. Brenner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Synovial fibroblasts are thought to be central mediators of joint destruction in rheumatoid arthritis (RA). Here the authors use single-cell transcriptomics and flow cytometry to identify synovial fibroblast subsets that are expanded and display dist
Externí odkaz:
https://doaj.org/article/c5ce4a229b2441f988b5517aa170745b
Autor:
John D. Davis, Mohamed A. Kamal, Sivan Harel, Ching-Ha Lai, Matthew P. Kosloski, Christine Xu, Wenjun Zheng, George D Kalliolias
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 2, Pp 384-395 (2022)
Itepekimab is a monoclonal antibody that targets interleukin (IL‐33) and has been shown to reduce airway inflammation and associated tissue damage in preclinical studies. We assessed the safety, tolerability, pharmacokinetics (PKs), and pharmacodyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a3f165e488b44bd021d9921094db91
https://doaj.org/article/feb1920e777547ffb5e5c23f8ef174ce
https://doaj.org/article/feb1920e777547ffb5e5c23f8ef174ce
Autor:
Claire Q. Wang, Sokol Haxhinasto, Sandra Garcet, Norma Kunjravia, Inna Cueto, Juana Gonzalez, Darshna Rambhia, Olivier Harari, Matthew A. Sleeman, Jennifer D. Hamilton, Wei Keat Lim, Jan Freudenberg, George D. Kalliolias, Paresh Thakker, Robert Bissonnette, James G. Krueger
Publikováno v:
Journal of Investigative Dermatology. 143:87-97.e14
Palmoplantar pustular psoriasis (PPPP) and non‒pustular palmoplantar psoriasis (NPPP) are localized, debilitating forms of psoriasis. The inflammatory circuits involved in PPPP and NPPP are not well-understood. To compare the cellular and immunolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63458b00775e6bbbd1616fc8a68193b0
https://doi.org/10.1016/j.jid.2022.05.1094
https://doi.org/10.1016/j.jid.2022.05.1094
Autor:
Jong Dae Ji, Steven Zeng, Carmen Chai, Se Hwan Mun, Matthew Jundong Kim, Haemin Kim, Tae-Hwan Kim, Brian Oh, Kyung-Hyun Park-Min, Younseo Oh, Chitra Lekha Dahia, Seyeon Bae, George D. Kalliolias
Publikováno v:
Bone Research
Bone Research, Vol 9, Iss 1, Pp 1-11 (2021)
Bone Research, Vol 9, Iss 1, Pp 1-11 (2021)
Osteoclasts are bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathological bone erosion. Macrophage colony stimulating factor (M-CSF) is abundant in rheumatoid arthritis (RA). However, the role of M-CSF in arthri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a96f68459eda9753949f28a8a5dfef
http://europepmc.org/articles/PMC8528869
http://europepmc.org/articles/PMC8528869