Zobrazeno 1 - 10
of 87
pro vyhledávání: '"George D D Jones"'
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140975 (2015)
The Nek11 kinase is a potential mediator of the DNA damage response whose expression is upregulated in early stage colorectal cancers (CRCs). Here, using RNAi-mediated depletion, we examined the role of Nek11 in HCT116 WT and p53-null CRC cells expos
Externí odkaz:
https://doaj.org/article/3e53e015bcbe44df8ea10a2252752fe0
Autor:
George D. D. Jones, Mark D. Farrar, Marcus S. Cooke, Chiung-Wen Hu, Barbara Shih, Lesley E. Rhodes, Mu-Rong Chao, Donald Allan, Andy Vail
Publikováno v:
Free Radical Biology & Medicine
Skin melanisation ranges widely across human populations. Melanin has antioxidant properties and also acts as a filter to solar ultraviolet radiation (UVR) incident upon the skin. In this study we firstly examined whether melanin level might influenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee3612c0d6406f85557672d964a2444
https://doi.org/10.1016/j.freeradbiomed.2020.07.034
https://doi.org/10.1016/j.freeradbiomed.2020.07.034
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7195
Numerous studies have demonstrated the normal tissue-sparing effects of ultra-high dose rate ‘FLASH’ irradiation in vivo, with an associated reduction in damage burden being reported in vitro. Towards this, two key radiochemical mechanisms have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4745428556b50a38ff8575768ae0daf5
https://doi.org/10.3390/ijms24087195
https://doi.org/10.3390/ijms24087195
Autor:
George D. D. Jones, P. Symonds
Publikováno v:
Clinical Oncology. 31:269-271
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9acc7d579ae591ab40b323c218894cc
https://doi.org/10.1016/j.clon.2019.02.011
https://doi.org/10.1016/j.clon.2019.02.011
Autor:
Alaa S Alhegaili, Nicolas Sylvius, Mahsa Karbaschi, Matthew Blades, George D. D. Jones, Helen G. Tempest, Marcus S. Cooke, Yunhee Ji
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 20, p 5112 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 20
International Journal of Molecular Sciences
Volume 20
Issue 20
The distribution of DNA damage and repair is considered to occur heterogeneously across the genome. However, commonly available techniques, such as the alkaline comet assay or HPLC-MS/MS, measure global genome levels of DNA damage, and do not reflect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b013734dc24c7a426832ed323da0a30
https://www.mdpi.com/1422-0067/20/20/5112
https://www.mdpi.com/1422-0067/20/20/5112
Autor:
P. Symonds, George D. D. Jones
Publikováno v:
Clinical oncology (Royal College of Radiologists (Great Britain)). 31(7)
FLASH radiotherapy (FLASH-RT) is a technology that could modify the way radiotherapy is delivered in the future. This technique involves the ultra-fast delivery of radiotherapy at dose rates several orders of magnitude higher than those currently use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885123a154c3920f6a329602f5c97c26
https://pubmed.ncbi.nlm.nih.gov/31010708
https://pubmed.ncbi.nlm.nih.gov/31010708
Autor:
Paul Symonds, George D. D. Jones
Publikováno v:
Clinical Oncology. 32:479
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cca51606324fe1936ef5c50d159cc80
https://doi.org/10.1016/j.clon.2020.03.004
https://doi.org/10.1016/j.clon.2020.03.004
Publikováno v:
Clinical oncology (Royal College of Radiologists (Great Britain)). 31(5)
Radiotherapy is still a treatment of choice for many malignancies, often in combination with other strategies. However, its efficacy is limited by the dose that can be safely administered without eliciting serious side-effects, as well as the fact th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef16401806c784bdd65a4733d4f4e234
https://pubmed.ncbi.nlm.nih.gov/30826201
https://pubmed.ncbi.nlm.nih.gov/30826201
Autor:
Larissa Lezina, George D. D. Jones, Ruth V. Spriggs, Simon D. Wagner, Anne E. Willis, Carolyn J.P. Jones, Kate Dudek, Daniel O. Beck, Aleksandra Bzura, Graham Packham
CD40L/interleukin-4 (IL-4) stimulation occurs in vivo in the tumor microenvironment and induces global translation to varying degrees in individuals with chronic lymphocytic leukemia (CLL) in vitro. However, the implications of CD40L/IL-4 for the tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c9881dd793a18543057a6e3a63406e
https://eprints.soton.ac.uk/423934/
https://eprints.soton.ac.uk/423934/
Autor:
Hussein H. K. Abbas, George D. D. Jones, Steven S. Foster, Kheloud M. H. Alhamoudi, Mark D. Evans
Publikováno v:
BMC Cancer
BMC Cancer, Vol 18, Iss 1, Pp 1-15 (2018)
BMC Cancer, Vol 18, Iss 1, Pp 1-15 (2018)
BackgroundTargeted therapies are based on exploiting cancer-cell-specific genetic features or phenotypic traits to selectively kill cancer cells while leaving normal cells unaffected. Oxidative stress is a cancer hallmark phenotype. Given that free n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038a9f0055deb5b3365d45ff3dea897d
https://doi.org/10.1186/s12885-018-4332-7
https://doi.org/10.1186/s12885-018-4332-7