Zobrazeno 1 - 10
of 36
pro vyhledávání: '"George D Cresswell"'
Autor:
Ingrid M. Saldana-Guerrero, Luis F. Montano-Gutierrez, Katy Boswell, Christoph Hafemeister, Evon Poon, Lisa E. Shaw, Dylan Stavish, Rebecca A. Lea, Sara Wernig-Zorc, Eva Bozsaky, Irfete S. Fetahu, Peter Zoescher, Ulrike Pötschger, Marie Bernkopf, Andrea Wenninger-Weinzierl, Caterina Sturtzel, Celine Souilhol, Sophia Tarelli, Mohamed R. Shoeb, Polyxeni Bozatzi, Magdalena Rados, Maria Guarini, Michelle C. Buri, Wolfgang Weninger, Eva M. Putz, Miller Huang, Ruth Ladenstein, Peter W. Andrews, Ivana Barbaric, George D. Cresswell, Helen E. Bryant, Martin Distel, Louis Chesler, Sabine Taschner-Mandl, Matthias Farlik, Anestis Tsakiridis, Florian Halbritter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Early childhood tumours arise from transformed embryonic cells, which often carry large copy number alterations (CNA). However, it remains unclear how CNAs contribute to embryonic tumourigenesis due to a lack of suitable models. Here we empl
Externí odkaz:
https://doaj.org/article/869f81138e26465185ec2a1246dd0cf6
Autor:
Ahmet Acar, Daniel Nichol, Javier Fernandez-Mateos, George D. Cresswell, Iros Barozzi, Sung Pil Hong, Nicholas Trahearn, Inmaculada Spiteri, Mark Stubbs, Rosemary Burke, Adam Stewart, Giulio Caravagna, Benjamin Werner, Georgios Vlachogiannis, Carlo C. Maley, Luca Magnani, Nicola Valeri, Udai Banerji, Andrea Sottoriva
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Evolutionary steering uses therapies to control tumour evolution by exploiting trade-offs. Here, using a barcoding approach applied to large cell populations, the authors explore evolutionary steering in lung cancer cells treated with EGFR inhibitors
Externí odkaz:
https://doaj.org/article/7266ff52e4984f1da8cfe86c3ba11937
Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking
Autor:
George D. Cresswell, Daniel Nichol, Inmaculada Spiteri, Haider Tari, Luis Zapata, Timon Heide, Carlo C. Maley, Luca Magnani, Gaia Schiavon, Alan Ashworth, Peter Barry, Andrea Sottoriva
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Tracking tumour evolution in a patient via circulating tumour DNA (ctDNA) is complicated due to the unknown mix of fragmented alleles from different cancer lesions. Here, the authors make use of a rapid autopsy program to demonstrate how representati
Externí odkaz:
https://doaj.org/article/98ada904713047afa84798009c85187b
Autor:
Benjamin Werner, Jack Case, Marc J. Williams, Ketevan Chkhaidze, Daniel Temko, Javier Fernández-Mateos, George D. Cresswell, Daniel Nichol, William Cross, Inmaculada Spiteri, Weini Huang, Ian P. M. Tomlinson, Chris P. Barnes, Trevor A. Graham, Andrea Sottoriva
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Quantifying somatic evolutionary processes in cancer and healthy tissue is a challenge. Here, the authors use single time point multi-region sampling of cancer and normal tissue, combined with evolutionary theory, to quantify in vivo mutation and cel
Externí odkaz:
https://doaj.org/article/1cc8e57a38b3428da9bd484790ebf103
Autor:
Taryn D. Treger, Tasnim Chagtai, Robert Butcher, George D. Cresswell, Reem Al-Saadi, Jesper Brok, Richard D. Williams, Chrissy Roberts, Nicholas M. Luscombe, Kathy Pritchard Jones, William Mifsud
Publikováno v:
Translational Oncology, Vol 11, Iss 6, Pp 1301-1306 (2018)
BACKGROUND: Diffuse anaplastic Wilms tumor (DAWT) is a rare, high-risk subtype that is often missed on diagnostic needle biopsy. Somatic mutations in TP53 are associated with the development of anaplasia and with poorer survival, particularly in adva
Externí odkaz:
https://doaj.org/article/91db7bd722744d7e9972c46a34a8b83c
Supplementary Figure 8 from The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer
Autor:
Andrea Sottoriva, Nicholas Turner, Gaia Schiavon, Yinyin Yuan, Rachael Natrajan, Carlo C. Maley, Mitch Dowsett, Francesca Muscara, Jennifer E. Rusby, Saira Khalique, Konrad Koelble, Lila Zabaglo, Hannah Cottom, Ian Said Huntingford, Luca Ermini, Kate Chkhaidze, Isaac Garcia-Murillas, Sarah Hrebien, Nicholas Trahearn, Ahmet Acar, George D. Cresswell, Daniel Nichol, Inmaculada Spiteri, Alexandra Vatsiou, Peter Barry
Figure S8. CCF comparisons between multiple tumour samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e14909e7526f88855b2f85c54402048
https://doi.org/10.1158/1078-0432.22470770.v1
https://doi.org/10.1158/1078-0432.22470770.v1
Autor:
Andrea Sottoriva, Nicholas Turner, Gaia Schiavon, Yinyin Yuan, Rachael Natrajan, Carlo C. Maley, Mitch Dowsett, Francesca Muscara, Jennifer E. Rusby, Saira Khalique, Konrad Koelble, Lila Zabaglo, Hannah Cottom, Ian Said Huntingford, Luca Ermini, Kate Chkhaidze, Isaac Garcia-Murillas, Sarah Hrebien, Nicholas Trahearn, Ahmet Acar, George D. Cresswell, Daniel Nichol, Inmaculada Spiteri, Alexandra Vatsiou, Peter Barry
Whole-exome sequencing mutations cancer cell fractions used in Figure S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab9de59a4fd3a9d387ffb9f298eb3e2
https://doi.org/10.1158/1078-0432.22470746
https://doi.org/10.1158/1078-0432.22470746
Autor:
Andrea Sottoriva, Nicholas Turner, Gaia Schiavon, Yinyin Yuan, Rachael Natrajan, Carlo C. Maley, Mitch Dowsett, Francesca Muscara, Jennifer E. Rusby, Saira Khalique, Konrad Koelble, Lila Zabaglo, Hannah Cottom, Ian Said Huntingford, Luca Ermini, Kate Chkhaidze, Isaac Garcia-Murillas, Sarah Hrebien, Nicholas Trahearn, Ahmet Acar, George D. Cresswell, Daniel Nichol, Inmaculada Spiteri, Alexandra Vatsiou, Peter Barry
Copy number alterations calls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043ce1557a5b6e269bec3a36b997e18f
https://doi.org/10.1158/1078-0432.22470776.v1
https://doi.org/10.1158/1078-0432.22470776.v1
Autor:
Andrea Sottoriva, Nicholas Turner, Gaia Schiavon, Yinyin Yuan, Rachael Natrajan, Carlo C. Maley, Mitch Dowsett, Francesca Muscara, Jennifer E. Rusby, Saira Khalique, Konrad Koelble, Lila Zabaglo, Hannah Cottom, Ian Said Huntingford, Luca Ermini, Kate Chkhaidze, Isaac Garcia-Murillas, Sarah Hrebien, Nicholas Trahearn, Ahmet Acar, George D. Cresswell, Daniel Nichol, Inmaculada Spiteri, Alexandra Vatsiou, Peter Barry
Supplementary Material and Methods Figure S1. Proportion of clonal and subclonal variants identified by whole exome sequencing. Figure S2. Mutation cancer cell fractions from whole-exome sequencing. Figure S4. Bootstrap values for targeted sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4c1b16efbef758e5a1b9cc6f150227
https://doi.org/10.1158/1078-0432.22470767
https://doi.org/10.1158/1078-0432.22470767
Supplementary Figure 3 from The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer
Autor:
Andrea Sottoriva, Nicholas Turner, Gaia Schiavon, Yinyin Yuan, Rachael Natrajan, Carlo C. Maley, Mitch Dowsett, Francesca Muscara, Jennifer E. Rusby, Saira Khalique, Konrad Koelble, Lila Zabaglo, Hannah Cottom, Ian Said Huntingford, Luca Ermini, Kate Chkhaidze, Isaac Garcia-Murillas, Sarah Hrebien, Nicholas Trahearn, Ahmet Acar, George D. Cresswell, Daniel Nichol, Inmaculada Spiteri, Alexandra Vatsiou, Peter Barry
Figure S3. Log-R-ratios and B-allele-frequency values.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ded9c88d89315292cf2ded1d1edcc7a
https://doi.org/10.1158/1078-0432.22470773
https://doi.org/10.1158/1078-0432.22470773