Ca2+-independent hypoxic vasorelaxation in porcine coronary artery

Autor: Min Gu, George D. Thorne, Yukisato Ishida, Richard J. Paul, Robert L. Wardle

Publikováno v: The Journal of Physiology. 562:839-846

To demonstrate a Ca2+-independent component of hypoxic vasorelaxation and to investigate its mechanism, we utilized permeabilized porcine coronary arteries, in which [Ca2+] could be clamped. Arteries permeabilized with β-escin developed maximum forc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0810b240528bfb526a228be9f2b2cbbb
https://doi.org/10.1113/jphysiol.2004.073692

Hypoxic vasorelaxation inhibition by organ culture correlates with loss of Kv channels but not Ca2+ channels

Autor: Richard J. Paul, George D. Thorne, Laura Conforti

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 283:H247-H253

We (Thorne GD, Shimizu S, and Paul RJ. Am J Physiol Cell Physiol 281: C24–C32, 2001) have recently shown that organ culture for 24 h specifically inhibits relaxation to acute hypoxia (95% N2-5% CO2) in the porcine coronary artery. Here we show simi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c562d11ec951853a7af10a8e6e2c83df
https://doi.org/10.1152/ajpheart.00569.2001

Topical paromomycin with or without gentamicin for cutaneous leishmaniasis

Autor: Diane Ullman, Aicha Boukthir, Nabil Belhadj Hamida, Ryan C. Adams, Kirsten S. Smith, Mourad Mokni, Jihene Bettaieb, Zaher El Ahmadi, Philip L. Smith, Adel Gharbi, Robert M. Rice, George D. Thorne, Nissaf Ben Alaya, A. Zaatour, Carl J. Nielsen, Jeanne A. Norwood, Max Grogl, Hechmi Louzir, Sadok Chlif, Gloria Morizot, William F. McCarthy, Alan J. Magill, Afif Ben Salah, Mara Kreishman-Deitrick, Karen M. Kopydlowski, Janet Ransom, Judith Berman, Pierre Buffet, Nathalie Ben Messaoud, Kidar Abdelhamid, Evelyn Guedri, Douglas B. Tang

Publikováno v: New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2013, 368 (6), pp.524-32. ⟨10.1056/NEJMoa1202657⟩
New England Journal of Medicine, 2013, 368 (6), pp.524-32. ⟨10.1056/NEJMoa1202657⟩

International audience; BACKGROUND: There is a need for a simple and efficacious treatment for cutaneous leishmaniasis with an acceptable side-effect profile. METHODS: We conducted a randomized, vehicle-controlled phase 3 trial of topical treatments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7048bbfb40ab6d667daf8f05bd432e4
https://hal-riip.archives-ouvertes.fr/pasteur-00793585/file/Topical_Paromomycin_with_or_without_Gentamicin_for_Cutaneous_Leishmaniasis.pdf

Ca2+-independent hypoxic vasorelaxation in porcine coronary artery

Autor: Min, Gu, George D, Thorne, Robert L, Wardle, Yukisato, Ishida, Richard J, Paul

Publikováno v: The Journal of physiology. 562(Pt 3)

To demonstrate a Ca(2+)-independent component of hypoxic vasorelaxation and to investigate its mechanism, we utilized permeabilized porcine coronary arteries, in which [Ca(2+)] could be clamped. Arteries permeabilized with beta-escin developed maximu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc7ddaac96ef946629ac6ab28e498c0c
https://pubmed.ncbi.nlm.nih.gov/15564284

Effects of organ culture on arterial gene expression and hypoxic relaxation: role of the ryanodine receptor

Autor: George D. Thorne, Richard J. Paul

Publikováno v: American journal of physiology. Cell physiology. 284(4)

Organ culture specifically inhibits vasorelaxation to acute hypoxia and preferentially decreases specific voltage-dependent K+channel expression over other K+and Ca2+channel subtypes. To isolate further potential oxygen-sensing mechanisms correlated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccacf7bb6eb7f533f4b8132237422f33
https://pubmed.ncbi.nlm.nih.gov/12477664