Morbidity and mortality in patients undergoing lower limb arthroplasty surgery during the initial surge of the COVID-19 pandemic in the UK at a single-speciality orthopaedic hospital

Autor: Yuvraj Agrawal, Ashish Vasudev, Akash Sharma, George Cooper, Jonathan Stevenson, Michael C. Parry, David Dunlop

Publikováno v: Bone & Joint Open, Vol 2, Iss 5, Pp 323-329 (2021)

Aims: The COVID-19 pandemic posed significant challenges to healthcare systems across the globe in 2020. There were concerns surrounding early reports of increased mortality among patients undergoing emergency or non-urgent surgery. We report the mor

Externí odkaz: https://doaj.org/article/14da97bdc6e943b88b3f06ffd04683cd

A transdisciplinary and community-driven database to unravel subduction zone initiation

Autor: Fabio Crameri, Valentina Magni, Mathew Domeier, Grace E. Shephard, Kiran Chotalia, George Cooper, Caroline M. Eakin, Antoniette Greta Grima, Derya Gürer, Ágnes Király, Elvira Mulyukova, Kalijn Peters, Boris Robert, Marcel Thielmann

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Despite numerous advances in our understanding of subduction since the theory of plate tectonics was established, the mechanisms of subduction zone initiation remain highly controversial. Here, the authors present a transdisciplinary and expandable c

Externí odkaz: https://doaj.org/article/75c539ae9c2346e19c0ead5932321f3b

Deoxyribose and deoxysugar derivatives from photoprocessed astrophysical ice analogues and comparison to meteorites

Autor: Michel Nuevo, George Cooper, Scott A. Sandford

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Sugars are known to form from the UV photoprocessing of ices under astrophysical conditions. Here, the authors report the detection of deoxyribose, the sugar of DNA, and other deoxysugars from the UV photoprocessing of H2O:CH3OH ice mixtures, which a

Externí odkaz: https://doaj.org/article/43b467e5b7b54cb283f02edc2c336d8e

NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease

Autor: Eilise M. Ryan, Pranvera Sadiku, Patricia Coelho, Emily R. Watts, Ailiang Zhang, Andrew J. M. Howden, Manuel A. Sanchez-Garcia, Martin Bewley, Joby Cole, Brian J. McHugh, Wesley Vermaelen, Bart Ghesquiere, Peter Carmeliet, Giovanny Rodriguez Blanco, Alex Von Kriegsheim, Yolanda Sanchez, William Rumsey, James F. Callahan, George Cooper, Nicholas Parkinson, Kenneth Baillie, Doreen A. Cantrell, John McCafferty, Gourab Choudhury, Dave Singh, David H. Dockrell, Moira K. B. Whyte, Sarah R. Walmsley

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 207:998-1011

Rationale: Chronic obstructive pulmonary disease (COPD) is a disease characterized by persistent airway inflammation and disordered macrophage function. The extent to which alterations in macrophage bioenergetics contribute to impaired antioxidant re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40854efbfdaf539694ed945e6a78bdf6
https://doi.org/10.1164/rccm.202203-0482oc

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

Autor: Ananda S. Mirchandani, Stephen J. Jenkins, Calum C. Bain, Manuel A. Sanchez-Garcia, Hannah Lawson, Patricia Coelho, Fiona Murphy, David M. Griffith, Ailiang Zhang, Tyler Morrison, Tony Ly, Simone Arienti, Pranvera Sadiku, Emily R. Watts, Rebecca. S. Dickinson, Leila Reyes, George Cooper, Sarah Clark, David Lewis, Van Kelly, Christos Spanos, Kathryn M. Musgrave, Liam Delaney, Isla Harper, Jonathan Scott, Nicholas J. Parkinson, Anthony J. Rostron, J. Kenneth Baillie, Sara Clohisey, Clare Pridans, Lara Campana, Philip Starkey Lewis, A. John Simpson, David H. Dockrell, Jürgen Schwarze, Nikhil Hirani, Peter J. Ratcliffe, Christopher W. Pugh, Kamil Kranc, Stuart J. Forbes, Moira K. B. Whyte, Sarah R. Walmsley

Publikováno v: Mirchandani, A S, Jenkins, S J, Bain, C C, Sanchez Garcia, M A, Lawson, H, Coelho, P, Murphy, F, Griffith, D, Zhang, A, Morrison, T, Ly, T, Arienti, S, Sadiku, P, Watts, E R, Dickinson, R, Reyes, L, Cooper, G, Clark, S, Lewis, D, Kelly, V, Spanos, C, Musgrave, K M, Delaney, L, Harper, I, Scott, J, Parkinson, N, Rostron, A J, Baillie, J K, Clohisey, S, Pridans, C, Campana, L, Starkey Lewis, P, Simpson, A J, Dockrell, D H, Schwarze, J, Hirani, N, Ratcliffe, P J, Pugh, C W, Kranc, K, Forbes, S J, Whyte, M K B & Walmsley, S R 2022, ' Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation ', Nature Immunology . https://doi.org/0.1038/s41590-022-01216-z

Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia, and its impact on immune responses, is often neglected. In the present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ab39b51379ba91e60afdc26dc1fbd1
https://doi.org/10.1038/s41590-022-01216-z