Zobrazeno 1 - 6
of 6
pro vyhledávání: '"George Cimis"'
Autor:
Kenneth P. Ellsworth, S. Mitra, Georgianna Harris, G.R. Rasmusson, Raman K. Bakshi, Jeffrey H. Toney, B. Chang, Walter F. Baginsky, R. L. Tolman, B. Azzolina, George Cimis, Herbert G. Bull
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 58:377-384
Steroid 5alpha-reductase is required for the conversion of testosterone to dihydrotestosterone. Localization of type 1 5alpha-reductase in the sebaceous gland of skin offers the possibility for selective inhibition of this isozyme as a treatment for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1e85dc33daf4854843601537d36d9c
https://doi.org/10.1016/0960-0760(96)00050-7
https://doi.org/10.1016/0960-0760(96)00050-7
Publikováno v:
Journal of Investigative Dermatology. 105:209-214
The presence of 5 alpha-reductase (5 alpha-R) in skin may indicate that the androgen regulation of sebaceous glands and sebum production requires the local conversion of testosterone to dihydrotestosterone. The goals of this study were to identify wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b64de5b784be695b859a8f2c59426d
https://doi.org/10.1111/1523-1747.ep12317162
https://doi.org/10.1111/1523-1747.ep12317162
Autor:
Richard L. Tolman, Susan Aster, Raman K. Bakshi, Jeffrey P. Bergman, Herb G. Bull, Benedict Chang, George Cimis, Michael P. Dolenga, Phillippe Durette, Kenneth Ellsworth, Craig Esser, Donald W. Graham, William K. Hagmann, Georgianna Harris, Ihor Kopka, Thomas Lanza, Gool Patel, Scott Polo, Gary H. Rasmusson, Soumya Sahoo, Jeffrey H. Toney, Derek Von Langen, Bruce Witzel
Publikováno v:
European Journal of Medicinal Chemistry. 30:311s-316s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdce1c65646d2979e6f48fc46946df19
https://doi.org/10.1016/s0223-5234(23)00132-0
https://doi.org/10.1016/s0223-5234(23)00132-0
Autor:
Raman K. Bakshi, Georgianna Harris, Gool F. Patel, Herb G. Bull, Kenneth P. Ellsworth, Gary H. Rasmusson, Walter F. Baginsky, B. Chang, George Cimis, Richard L. Tolman
Publikováno v:
Journal of Medicinal Chemistry. 37:3871-3874
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bc51a1712ed5655a3ac9868f11a0c5
https://doi.org/10.1021/jm00049a003
https://doi.org/10.1021/jm00049a003
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 66(5-6)
The rhesus macaque types 1 and 2 5alpha-reductase (5aR1 and 5aR2) were cloned and expressed in COS cells to facilitate comparison of rhesus and human 5aRs. The deduced protein sequences of the rhesus SaRs shared 94% and 96% identity with the human ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81ea8066accc746bd2d4d0f3b99e710
https://pubmed.ncbi.nlm.nih.gov/9749833
https://pubmed.ncbi.nlm.nih.gov/9749833
Autor:
Kenneth P. Ellsworth, Georgianna Harris, Richard L. Tolman, Gary H. Rasmusson, Walter F. Baginsky, Barbara Azzolina, Christian R. H. Raetz, George Cimis
Steroid 5 alpha-reductase (EC 1.3.1.22) catalyzes the reduction of testosterone to dihydrotestosterone. The 5 alpha-reductase found in human scalp has been compared with the enzyme found in prostate. The scalp reductase has a broad pH optimum centere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501b3e62f235e5b072142c4fca283150
https://europepmc.org/articles/PMC50427/
https://europepmc.org/articles/PMC50427/
