Zobrazeno 1 - 10
of 744
pro vyhledávání: '"George C. Tsokos"'
Autor:
Eri Katsuyama, Morgane Humbel, Abel Suarez-Fueyo, Abhigyan Satyam, Nobuya Yoshida, Vasileios C. Kyttaris, Maria G. Tsokos, George C. Tsokos
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract CD38 has emerged as a potential therapeutic target for patients with systemic lupus erythematosus (SLE) but it is not known whether CD38 alters CD4+ T cell function. Using primary human T cells and CD38-sufficient and CD38-deficient Jurkat T
Externí odkaz:
https://doaj.org/article/d0cd238c69d947889a5549cbde81b514
Autor:
Meng Xu, Taku Ito-Kureha, Hyun-Seo Kang, Aleksandar Chernev, Timsse Raj, Kai P. Hoefig, Christine Hohn, Florian Giesert, Yinhu Wang, Wenliang Pan, Natalia Ziętara, Tobias Straub, Regina Feederle, Carolin Daniel, Barbara Adler, Julian König, Stefan Feske, George C. Tsokos, Wolfgang Wurst, Henning Urlaub, Michael Sattler, Jan Kisielow, F. Gregory Wulczyn, Marcin Łyszkiewicz, Vigo Heissmeyer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/9e89d380ba524171be8ac6b2c5c274ad
Autor:
Meng Xu, Taku Ito-Kureha, Hyun-Seo Kang, Aleksandar Chernev, Timsse Raj, Kai P. Hoefig, Christine Hohn, Florian Giesert, Yinhu Wang, Wenliang Pan, Natalia Ziętara, Tobias Straub, Regina Feederle, Carolin Daniel, Barbara Adler, Julian König, Stefan Feske, George C. Tsokos, Wolfgang Wurst, Henning Urlaub, Michael Sattler, Jan Kisielow, F. Gregory Wulczyn, Marcin Łyszkiewicz, Vigo Heissmeyer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The regulation of thymocyte development by RNA-binding proteins (RBPs) is largely unexplored. We identify 642 RBPs in the thymus and focus on Arpp21, which shows selective and dynamic expression in early thymocytes. Arpp21 is downregulated i
Externí odkaz:
https://doaj.org/article/c1ccb1c3902a42deb7a8b59d19e9f6cb
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114379- (2024)
Summary: The protein phosphatase 2A (PP2A) regulatory subunit PPP2R2A is involved in the regulation of immune response. We report that lupus-prone mice with T cells deficient in PPP2R2A display less autoimmunity and nephritis. PPP2R2A deficiency prom
Externí odkaz:
https://doaj.org/article/4301456793754b668d157f3b9275f2d3
Autor:
Marc Scherlinger, Hao Li, Wenliang Pan, Wei Li, Kohei Karino, Theodoros Vichos, Afroditi Boulougoura, Nobuya Yoshida, Maria G. Tsokos, George C. Tsokos
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by dysregulated B cell compartment responsible for the production of autoantibodies. Here, we show that T cell-specific expression of calcium/calmodulin-dependent prot
Externí odkaz:
https://doaj.org/article/2b332fe762944cbb829b78d049a34058
Publikováno v:
European Journal of Rheumatology, Vol 10, Iss 4, Pp 148-158 (2023)
Externí odkaz:
https://doaj.org/article/ebd9f72e2d2447ea89b2e7d07f382734
Autor:
Jing Zhao, Sungwook Jung, Xiaofei Li, Lushen Li, Vivek Kasinath, Hengcheng Zhang, Said N. Movahedi, Ahmad Mardini, Gianmarco Sabiu, Yoonha Hwang, Vikas Saxena, Yang Song, Bing Ma, Sophie E. Acton, Pilhan Kim, Joren C. Madsen, Peter T. Sage, Stefan G. Tullius, George C. Tsokos, Jonathan S. Bromberg, Reza Abdi
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Here, we investigated how fibroblastic reticular cells (FRCs) facilitate the tolerance induced by anti-CD40L in a murine model of heart transpla
Externí odkaz:
https://doaj.org/article/bc8427fba19b4be3b7fbe037cc02ca92
Autor:
Xunyao Wu, Yi Liu, Shanzhao Jin, Min Wang, Yuhao Jiao, Bo Yang, Xin Lu, Xin Ji, Yunyun Fei, Huaxia Yang, Lidan Zhao, Hua Chen, Yaran Zhang, Hao Li, Peter E. Lipsky, George C. Tsokos, Fan Bai, Xuan Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Patients with rheumatoid arthritis are commonly stratified by ACPA serology, with positivity being associated with more severe disease and joint destruction. Here the authors present a single cell RNA sequencing resource comparing peripheral blood an
Externí odkaz:
https://doaj.org/article/a76d17f2901f409b96a7a520d3bb90cf
Autor:
Li Dai, Mayuko Uehara, Xiaofei Li, Brenna A. LaBarre, Naima Banouni, Takaharu Ichimura, Melissa M. Lee-Sundlov, Vivek Kasinath, Jade A. Sullivan, Heyu Ni, Francesca Barone, Silvia Giannini, Baharak Bahmani, Peter T. Sage, Nikolaos A. Patsopoulos, George C. Tsokos, Jonathan S. Bromberg, Karin Hoffmeister, Liwei Jiang, Reza Abdi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Lymph nodes (LNs) are the critical sites of immunity, and the stromal cells of LNs are crucial to their function. Our understanding of the stromal compartment of the LN has deepened recently with the characterization of nontraditional stromal cells.
Externí odkaz:
https://doaj.org/article/3dc4347bd1d44db88e9d3b536cdd3e39
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Lupus nephritis (LN) is common in people with systemic lupus erythematosus (SLE) and advances, almost invariably, to end-stage renal disease (ESRD). In this issue of the JCI, Abraham, Durkee, et al. presented a large-scale immune cell landscape of ki
Externí odkaz:
https://doaj.org/article/2af451a30a424181983e80469bd542d9