Zobrazeno 1 - 10
of 347
pro vyhledávání: '"George C Prendergast"'
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0276910 (2022)
Ulcerative colitis (UC) is a common chronic disease of the large intestine. Current anti-inflammatory drugs prescribed to treat this disease have limited utility due to significant side-effects. Thus, immunotherapies for UC treatment are still sought
Externí odkaz:
https://doaj.org/article/1d6c24e80b754b0a998ca0ee3ec92a49
Autor:
Arturo Bravo-Nuevo, Alice Marcy, Minzhou Huang, Frank Kappler, Jennifer Mulgrew, Lisa Laury-Kleintop, Melvin Reichman, Annette Tobia, George C Prendergast
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90031 (2014)
Metabolic syndrome, diabetes and diabetes complications pose a growing medical challenge worldwide, accentuating the need of safe and effective strategies for their clinical management. Here we present preclinical evidence that the sorbitol derivativ
Externí odkaz:
https://doaj.org/article/028aec2c386442f4a5d19bc9bf208a09
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49615 (2012)
Stimulation of the receptor tyrosine kinase KIT by Stem Cell Factor (SCF) triggers activation of RAS and its downstream effectors. Proper KIT activation is essential for the maturation, survival and proliferation of mast cells. In addition, SCF activ
Externí odkaz:
https://doaj.org/article/7b952aaf2a074921b6aa8eb8fa055273
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7102 (2009)
Myelodysplastic syndrome (MDS) is characterized by ineffective hematopoiesis and hyperplastic bone marrow. Complete loss or interstitial deletions of the long arm of chromosome 5 occur frequently in MDS. One candidate tumor suppressor on 5q is the ma
Externí odkaz:
https://doaj.org/article/0bd4c0189e3344a5b82975dcde8e79d0
There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas
Publikováno v:
The Cancer Journal. 29:34-37
There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer and it offers radically new ideas
Autor:
Lauren M. F. Merlo, James B. DuHadaway, James D. Montgomery, Wei-Dan Peng, Peter J. Murray, George C. Prendergast, Andrew J. Caton, Alexander J. Muller, Laura Mandik-Nayak
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Indoleamine-2,3-dioxygenase (IDO)1 and IDO2 are two closely related tryptophan catabolizing enzymes encoded by linked genes. The IDO pathway is also immunomodulatory, with IDO1 well-characterized as a mediator of tumor immune evasion. Due to its homo
Externí odkaz:
https://doaj.org/article/564df2743520466b8950a559dcc7cf6e
Autor:
Laura Mandik-Nayak, James B. DuHadaway, Jennifer Mulgrew, Elizabeth Pigott, Kaylend Manley, Summer Sedano, George C. Prendergast, Lisa D. Laury-Kleintop
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 11, Pp 1313-1322 (2017)
During the development of autoimmune disease, a switch occurs in the antibody repertoire of B cells so that the production of pathogenic rather than non-pathogenic autoantibodies is enabled. However, there is limited knowledge concerning how this piv
Externí odkaz:
https://doaj.org/article/42ba5a95c4b349389a6e4f816a090987
Ulcerative colitis (UC) is an idiopathic disease of the large intestine linked to high fat-high protein diets, a dysbiotic microbiome, and a metabolome linked to diet and/or aberrant circadian rhythms associated with poor sleeping patterns. Understan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22cfcd61a400ab6eb91da93d81039524
https://doi.org/10.21203/rs.3.rs-2846587/v1
https://doi.org/10.21203/rs.3.rs-2846587/v1