Zobrazeno 1 - 9
of 9
pro vyhledávání: '"George C, Morton"'
Autor:
Carrie Xu, George C. Morton, Vinayak Hosagrahara, Shung Wu, Denis E. Ryono, Jonathan Lippy, Narayanan Hariharan, Kenneth T. Locke, Xiang-Xang Ye, Wei Wang, Liqun Gu, Yi-Xin Li, Fucheng Qu, Peter T. W. Cheng, Sean S. Chen, Kevin O’Malley, Michael Cap, Robert Zahler, Tao Wang, Lori Kunselman, Charles Z. Ding, Cuixia Chu, Rebecca A. Smirk, Neil Flynn, Pratik Devasthale, Hao Zhang, Nathan Morgan, Atsu Apedo, Thomas Harrity, Lisa Zhang, Dennis Farrelly, Arthur M. Doweyko, Zhi Lai, Tim Herpin, Pathanjali Kadiyala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1196-1205
The design, synthesis and structure–activity relationships of a novel series of 3,4-disubstituted pyrrolidine acid analogs as PPAR ligands is outlined. In both the 1,3- and 1,4-oxybenzyl pyrrolidine acid series, the preferred stereochemistry was sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9c9221e9206ed0e57f44f10281d7ab
https://doi.org/10.1016/j.bmcl.2015.01.066
https://doi.org/10.1016/j.bmcl.2015.01.066
Autor:
Thomas J. Connors, Jie Qian, Zeck Huang, Joanne R. Mathiasen, Edward R. Bacon, Thelma S. Angeles, Mark J. Huffman, Emir Duzic, Joseph M. Salvino, Beth Ann McKenna, Hervé Schaffhauser, Robert J. McHugh, Lily D. Lu, George C. Morton, Beverly P. Holskin, Karla Kopec, Amy DiCamillo, Gerard C. Rosse, Chrysanthe Spais, Rabindranath Tripathy, Lisa D. Aimone
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1421-1426
Serotoninergic neurotransmission has been implicated in modulation of learning and memory. It has been demonstrated that 5-hydroxytryptamine(6) (5-HT(6)) receptor antagonists show beneficial effect on cognition in several animal models. Based on a ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33e912dffb6b9ff1c34528c45a1f47ab
https://doi.org/10.1016/j.bmcl.2011.12.026
https://doi.org/10.1016/j.bmcl.2011.12.026
Autor:
Beverly P. Holskin, Karla Kopec, Joanne R. Mathiasen, Amy DiCamillo, Babu G. Sundar, Thomas J. Connors, Emir Duzic, Edward R. Bacon, Gerard C. Rosse, Chrysanthe Spais, Thomas R. Bailey, Beth Ann McKenna, Rebecca A. Brown, Jie Qian, Derek Dunn, Mark J. Huffman, Joseph M. Salvino, Huang Zeqi, Lisa D. Aimone, Hervé Schaffhauser, Deborah Galinis, Thelma S. Angeles, Lily D. Lu, George C. Morton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:120-123
7-Arylsulfonyl substituted benzofuropiperidine was discovered as a novel scaffold for 5HT(6) receptor antagonists. Optimization by substitution at C-1 position led to identification of selective, orally bioavailable, brain penetrant antagonists with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a63c099e60dd280977edea44193b5a96
https://doi.org/10.1016/j.bmcl.2011.11.050
https://doi.org/10.1016/j.bmcl.2011.11.050
Autor:
Kenneth E. Carlson, Stephen G. Walker, Barry Koplowitz, Kathleen M. Gillooly, John W. Haycock, Kim W. McIntyre, Ximao Wu, Stephen Roberts, Guixue Yu, John E. Macor, George C. Morton, Huji Tuerdi, Yifan Yang, Timothy F. Herpin, R. Michael Lawrence, Liya Kang, Judy Wardwell-Swanson, Ashish Khanna
Publikováno v:
Journal of Leukocyte Biology. 80:897-904
It is well established that melanocortins are peptides that have potent anti-inflammatory activity. Recent research has focused on understanding which of the known melanocortin receptors mediates the anti-inflammatory actions of the melanocortins. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49eae78aadd18c8896ae186501df670d
https://doi.org/10.1189/jlb.1204748
https://doi.org/10.1189/jlb.1204748
Autor:
Kenneth E. Carlson, John S. Tokarski, George C. Morton, R. Michael Lawrence, Guixue Yu, Huji Tuerdi, John E. Macor, Timothy F. Herpin, Ximao Wu, Liya Kang, Ashish Khanna
Publikováno v:
Journal of Medicinal Chemistry. 46:1123-1126
The melanocortin-1 receptor (MC-1R) is a G-protein-coupled receptor involved in inflammation and skin pigmentation. Compound 2 is the first highly potent and selective MC-1R small-molecule agonist reported. Compound 2 showed efficacy in an acute mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27cd19e9c4e3016d60a567ef90ee1f5
https://doi.org/10.1021/jm025600i
https://doi.org/10.1021/jm025600i
Autor:
Rabindranath, Tripathy, Robert J, McHugh, Edward R, Bacon, Joseph M, Salvino, George C, Morton, Lisa D, Aimone, Zeck, Huang, Joanne R, Mathiasen, Amy, DiCamillo, Mark J, Huffman, Beth A, McKenna, Karla, Kopec, Lily D, Lu, Jie, Qian, Thelma S, Angeles, Thomas, Connors, Chrysanthe, Spais, Beverly, Holskin, Emir, Duzic, Hervé, Schaffhauser, Gerard C, Rossé
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(3)
Serotoninergic neurotransmission has been implicated in modulation of learning and memory. It has been demonstrated that 5-hydroxytryptamine(6) (5-HT(6)) receptor antagonists show beneficial effect on cognition in several animal models. Based on a ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbd67be491fa50904fc04fc20c374a04
https://pubmed.ncbi.nlm.nih.gov/22226656
https://pubmed.ncbi.nlm.nih.gov/22226656
Autor:
Babu G, Sundar, Thomas R, Bailey, Derek D, Dunn, Edward R, Bacon, Joseph M, Salvino, George C, Morton, Lisa D, Aimone, Huang, Zeqi, Joanne R, Mathiasen, Amy, Dicamillo, Mark J, Huffman, Beth A, McKenna, Karla, Kopec, Lily D, Lu, Rebecca, Brown, Jie, Qian, Thelma, Angeles, Thomas, Connors, Chrysanthe, Spais, Beverly, Holskin, Deborah, Galinis, Emir, Duzic, Herve, Schaffhauser, Gerard C, Rosse
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
7-Arylsulfonyl substituted benzofuropiperidine was discovered as a novel scaffold for 5HT(6) receptor antagonists. Optimization by substitution at C-1 position led to identification of selective, orally bioavailable, brain penetrant antagonists with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b0ab8369735ed85da9712148db21027
https://pubmed.ncbi.nlm.nih.gov/22153937
https://pubmed.ncbi.nlm.nih.gov/22153937
Autor:
R. Michael Lawrence, George C. Morton, Mark E. Salvati, Jonathan O’Connell, Ramakrishna Seethala, Arthur V. Miller, Tara L. Peterson, Cooper Christopher B, Carolyn A. Weigelt, Yalei Liu, Tammy C. Wang, Lalgudi S. Harikrishnan, Timothy F. Herpin, Kingsley K. Appiah, David S. Taylor, Xiaohong Yin, Muthoni G. Kamau, Jennifer X. Qiao, Leonard P. Adam, Alice Ye A. Chen, David S. Nirschl
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(8)
2-Arylbenzoxazole 5 was identified as a hit from a fluorescence-based high-throughput screen for CETP inhibitors. The synthesis and SAR investigation employing array synthesis of the A- and B-rings are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cb06dc4861759c7d2f7f37b9fbbffa
https://pubmed.ncbi.nlm.nih.gov/18374566
https://pubmed.ncbi.nlm.nih.gov/18374566
Autor:
Timothy F, Herpin, George C, Morton
Publikováno v:
Methods in enzymology. 369
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96bee1eabb264e9194fcdecaaad6ebd4
https://pubmed.ncbi.nlm.nih.gov/14722948
https://pubmed.ncbi.nlm.nih.gov/14722948