Zobrazeno 1 - 10
of 96
pro vyhledávání: '"George B. Spiegelman"'
Autor:
Grace Yim, Peter Axerio-Cilies, Charles J. Thompson, George B. Spiegelman, Artem Cherkasov, Michael Hsing, Ján Burian
Publikováno v:
Nucleic Acids Research
Tuberculosis therapeutic options are limited by the high intrinsic antibiotic resistance of Mycobacterium tuberculosis. The putative transcriptional regulator WhiB7 is crucial for the activation of systems that provide resistance to diverse antibioti
Publikováno v:
Molecular Microbiology. 83:759-774
The gtaI gene of Rhodobacter capsulatus encodes an N-acyl-homoserine lactone (acyl-HSL) synthase. Immediately 5′ of the gtaI gene is ORF rcc00328 that encodes a potential acyl-HSL receptor protein. A combination of genetic and biochemical approache
Publikováno v:
Journal of Biological Chemistry. 285:41374-41379
RasC is required for optimum activation of adenylyl cyclase A and for aggregate stream formation during the early differentiation of Dictyostelium discoideum. RasG is unable to substitute for this requirement despite its sequence similarity to RasC.
Publikováno v:
CBE Life Sciences Education
Invention activities challenge students to tackle problems that superficially appear unrelated to the course material but illustrate underlying fundamental concepts that are fundamental to material that will be presented. During our invention activit
Publikováno v:
Journal of Bacteriology. 191:5489-5498
In Bacillus species, the master regulator of sporulation is Spo0A. Spo0A functions by both activating and repressing transcription initiation from target promoters that contain 0A boxes, the binding sites for Spo0A. Several classes of spo0A mutants h
Publikováno v:
Journal of Bioeconomics. 9:265-277
It has been proposed that open thermodynamic systems will act to dissipate available energy gradients by self-organizing into coherent structures that, with time, evolve and develop into nested hierarchies – panarchies – that adapt to internal an
Publikováno v:
Journal of Bacteriology. 188:7988-7991
Promoter- lux fusions that showed rifampin-modulated transcription were identified from a Salmonella enterica serovar Typhimurium 14028 reporter library. The transformation of a subset of fusions into mutants that lacked one of six global regulatory
Publikováno v:
Developmental Biology. 284:412-420
The disruption of the gene encoding the Dictyostelium Ras subfamily protein, RasC results in a strain that fails to aggregate with defects in both cAMP signal relay and chemotaxis. Restriction enzyme mediated integration disruption of a second gene i
Autor:
Gerald Weeks, George B. Spiegelman, David Secko, Chinten James Lim, Meenal Khosla, Karl A. Zawadzki
Publikováno v:
Experimental Cell Research. 306:47-55
In addition to its previously established roles in cAMP relay and cAMP chemotaxis, loss of signal transduction through the RasC protein was found to impact a number of vegetative cell functions. Vegetative rasC- cells exhibited reduced random motilit
Autor:
George B. Spiegelman, Brett N. McLeod
Publikováno v:
Journal of Bacteriology. 187:2532-2536
The ParA family protein Soj appears to negatively regulate sporulation in Bacillus subtilis by inhibiting transcription from promoters that are activated by phosphorylated Spo0A. We tested in vitro Soj inhibition of Spo0A-independent variants of a pr