Výsledky vyhledávání - "George B. Naff"

Activation of protein mediators of inflammation and evidence for endotoxemia in Borrelia recurrentis infection

Autor: Robert E. Galloway, George H. Goldsmith, Thomas Butler, Hidehiko Saito, Jack Levin, Sissay Awoke, Craig K. Wallace, George B. Naff

Publikováno v: The American Journal of Medicine. 63:933-938

Fifteen patients with Borrelia recurrentis infection were studied to evaluate the role of certain plasma proteins and endotoxin in the pathophysiology of both the acute illness and the Jarisch-Herxheimer-like reaction. The causative spirochetes disap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9f7141f6215b9e172e42ba36288a72
https://doi.org/10.1016/0002-9343(77)90548-4

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Contribution of Toxic Oxygen Intermediates to Complement-induced Reductions in Effective Hepatic Blood Flow

Autor: William J. Schirmer, George B. Naff, Donald E. Fry, James M. Schirmer

Publikováno v: The Journal of Trauma: Injury, Infection, and Critical Care. 28:1295-1300

This study examines the effects of complement activation and of complement-induced oxygen radical production on the principal determinant of hepatic function, i.e., effective hepatic blood flow (EHBF). Female Sprague-Dawley rats received cobra venom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b4f2e0d293b06fea0ecf587107c2c4
https://doi.org/10.1097/00005373-198809000-00001

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Metabolism of C4 and linkage analysis in a kindred with hereditary incomplete C4 deficiency

Autor: George B. Naff, Jeanne E. Anderson, Chester A. Alper, Jeffrey J. Wisnieski, Michael H. Nathanson, Alvin E. Davis

Publikováno v: Arthritis & Rheumatism. 30:919-926

We studied a kindred in which C4 deficiency had been discovered. Unlike families with total absence of C4, in this kindred C4 deficiency was found to be incomplete, autosomal dominant, not caused by null alleles, and not associated with a high incide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c953dde894e3f9f3cac8c0c7a1e0c5f
https://doi.org/10.1002/art.1780300812

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Allopurinol and lodoxamide in complement-induced hepatic ischemia

Autor: James M. Schirmer, George B. Naff, William J. Schirmer, Donald E. Fry

Publikováno v: Journal of Surgical Research. 45:28-36

Intravascular complement activation with either zymosan or cobra venom factor (CVF) impairs hepatic blood flow. Oxygen radical scavengers given at the time of complement activation attenuate the resulting hepatic ischemia. It is not clear whether com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20830a76bb8cfb7a76907096f10a3fdb
https://doi.org/10.1016/0022-4804(88)90017-0

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THE CONVERSION OF C'1S TO C'1 ESTERASE BY PLASMIN AND TRYPSIN

Autor: George B. Naff, Oscar D. Ratnoff

Publikováno v: Journal of Experimental Medicine. 125:337-358

The formation of C'1 esterase from C'1, the first component of complement, may be brought about by the action of plasmin or trypsin upon C'1s, a subcomponent of C'1. These enzymes also decrease the esterolytic activity of C'1 esterase. The formation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01c9c74447685704be00af91518b033b
https://doi.org/10.1084/jem.125.2.337

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THE ENZYMATIC NATURE OF C'1r

Autor: Oscar D. Ratnoff, George B. Naff

Publikováno v: The Journal of Experimental Medicine

Human C'1, a macromolecular complex composed of three subunits, is the zymogen for at least two distinct enzymes. Preparations of one subunit, C'1r, functioned as a protease which converted another subunit, C'1s, to C'1 esterase. The conversion of C'

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361a00300c4e3c06401b9a92b3e1e4be
https://doi.org/10.1084/jem.128.4.571

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Glomerular deposition of properdin in acute and chronic glomerulonephritis with hypocomplementemia

Autor: George B. Naff, John T. Boyer, Alfred F. Michael, N. Gunnar Westberg

Publikováno v: Journal of Clinical Investigation. 50:642-649

Kidney tissue from 97 patients was studied by immunofluorescent techniques using antiserum to purified properdin. All patients with acute poststreptococcal glomerulonephritis showed deposition of properdin and the third component of complement (C3),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::775e35ecea873cc560de491f8d4586f4
https://doi.org/10.1172/jci106534

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THE INHIBITION OF PLASMIN, PLASMA KALLIKREIN, PLASMA PERMEABILITY FACTOR, AND THE C'1r SUBCOMPONENT OF THE FIRST COMPONENT OF COMPLEMENT BY SERUM C'1 ESTERASE INHIBITOR

Autor: Oscar D. Ratnoff, George B. Naff, Jack Pensky, D. Ogston

Publikováno v: The Journal of Experimental Medicine

The fraction of human serum designated as C'1 esterase inhibitor is known to inhibit the action of C'1 esterase, a plasma kallikrein, and PF/Dil, an enzyme in plasma enhancing cutaneous vascular permeability. In the present study, C'1 esterase inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad83d21963508e5b33511aacb8e48161
http://europepmc.org/articles/PMC2138601

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