Lentiviral in situ targeting of stem cells in unperturbed intestinal epithelium

Autor: George B. Garside, Madeline Sandoval, Slobodan Beronja, K. Lenhard Rudolph

Publikováno v: BMC Biology, Vol 21, Iss 1, Pp 1-12 (2023)

Abstract Background Methods for the long-term in situ transduction of the unperturbed murine intestinal epithelium have not been developed in past research. Such a method could speed up functional studies and screens to identify genetic factors influ

Externí odkaz: https://doaj.org/article/33b2e89d547c4e1a91b000ef317c7a21

Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction

Autor: Nadja Gebert, Chia-Wei Cheng, Joanna M. Kirkpatrick, Domenico Di Fraia, Jina Yun, Patrick Schädel, Simona Pace, George B. Garside, Oliver Werz, K. Lenhard Rudolph, Henri Jasper, Ömer H. Yilmaz, Alessandro Ori

Publikováno v: Cell Reports, Vol 31, Iss 4, Pp - (2020)

Summary: The small intestine is responsible for nutrient absorption and one of the most important interfaces between the environment and the body. During aging, changes of the epithelium lead to food malabsorption and reduced barrier function, thus i

Externí odkaz: https://doaj.org/article/6ec250b7c1924a2c8eabf6e16788b454

The Cdc14 Phosphatase Controls Resolution of Recombination Intermediates and Crossover Formation during Meiosis

Autor: Rokas Grigaitis, Paula Alonso-Ramos, Teresa Bermejo, David Álvarez-Melo, Carolina Pascual-Silva, Katerina Strouhalova, Meret Arter, Joao Matos, George B. Garside, Pedro A. San-Segundo, Jesús A. Carballo, Rahel Wettstein, Marta Fernández-Díaz, Marco Geymonat

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 9811, p 9811 (2021)
International Journal of Molecular Sciences, 22 (18)
Digital.CSIC. Repositorio Institucional del CSIC
instname
International Journal of Molecular Sciences
Volume 22
Issue 18

Meiotic defects derived from incorrect DNA repair during gametogenesis can lead to mutations, aneuploidies and infertility. The coordinated resolution of meiotic recombination intermediates is required for crossover formation, ultimately necessary fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cc3863d969ad60771a2f0b7c582586
https://www.mdpi.com/1422-0067/22/18/9811

Short-term dietary restriction in old mice rejuvenates the aging-induced structural imbalance of gut microbiota

Autor: Ting Zeng, Si Tao, Hui Cui, Liu Zhang, Zhendong Tao, Yiting Wang, Jianying Wu, Duozhuang Tang, George B. Garside

Publikováno v: Biogerontology

The world’s aging population is growing rapidly. Incidences of multiple pathologies, such as abdominal obesity, cardiovascular and cerebrovascular diseases, type 2 diabetes, and malignant neoplasms, increase sharply with age. Aged individuals posse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34320a6d8963d16a5a924112ba395783
http://europepmc.org/articles/PMC6790194

Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction

Autor: K. Lenhard Rudolph, Chia-Wei Cheng, George B. Garside, Joanna Kirkpatrick, Ömer H. Yilmaz, Henri Jasper, Domenico Di Fraia, Jina Yun, Nadja Gebert, Alessandro Ori, Patrick Schädel, Simona Pace, Oliver Werz

Publikováno v: Cell Reports
Cell reports
Cell Reports, Vol 31, Iss 4, Pp-(2020)
Elsevier

SUMMARY The small intestine is responsible for nutrient absorption and one of the most important interfaces between the environment and the body. During aging, changes of the epithelium lead to food malabsorption and reduced barrier function, thus in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a2b7f997615e021a0e4dfefe86c86d