Výsledky vyhledávání - "George B. Dawe"

Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors

Autor: Mohammad Fahim Kadir, Camilo Navarrete, Christian Fuentes, R. Venskutonyte, M. Arsenault, Amanda M Perozzo, E.A. Santander, Y. Yan, John Michael Edwardson, Ryan P.D. Alexander, Derek Bowie, Jette S. Kastrup, Mark R. P. Aurousseau, Karla Frydenvang, Nelson P. Barrera, George B. Dawe

Publikováno v: Neuron. 102(5)

Summary Neurotransmitter-gated ion channels are allosteric proteins that switch on and off in response to agonist binding. Most studies have focused on the agonist-bound, activated channel while assigning a lesser role to the apo or resting state. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb58497e10f5d2bfe9e6643645fecd31
https://pubmed.ncbi.nlm.nih.gov/31053408

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Re-Evaluating a Proposed Mechanism for Ion Modulation in Kainate Receptors

Autor: Maria Musgaard, Derek Bowie, Mark R. P. Aurousseau, Elizabeth D. Andrews, Bryan A. Daniels, George B. Dawe, Philip C. Biggin

Glutamate is the major excitatory neurotransmitter in the brain, activating ionotropic receptors named for their selectivity to the agonists NMDA, AMPA, and kainate (KARs). The KAR subunit GluK2 requires external ions, in addition to glutamate, to pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31fc6f9bf95a5f690af8eccab126748
https://ora.ox.ac.uk/objects/uuid:cbb20fad-d794-41b8-968d-0be17447fb9c

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Mechanism of AMPA Receptor Gating Re-Shaped by Auxiliary Proteins

Autor: George B. Dawe, Derek Bowie

Publikováno v: Biophysical Journal. 110(3)

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate excitation in the mammalian central nervous system. Amongst iGluRs, the AMPA receptor (AMPAR) subfamily facilitates the initial depolarization of postsynaptic terminal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d91d22b0f6bf60272b518e2ce14f43f

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Characterization of a 'Hotspot' in the AMPA Receptor Activation Pathway

Autor: Derek Bowie, Maria Musgaard, Mark R. P. Aurousseau, George B. Dawe, Philip C. Biggin

Publikováno v: Biophysical Journal. 108(2)

Ionotropic glutamate receptors (iGluRs) facilitate the bulk of synaptic excitation in the mammalian central nervous system. Structures of full-length, AMPA-type iGluRs (AMPARs) have recently been reported in conformations thought to represent resting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16eeb8564974e3c3c76e11ba64580815

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Functional Consequences of Cysteine Mutations at the Kainate Receptor Dimer Interface

Autor: Philip C. Biggin, Maria Musgaard, George B. Dawe, Bryan A. Daniels, Derek Bowie, Mark R. P. Aurousseau

Publikováno v: Biophysical Journal. 106(2)

The cation-binding pocket is integral to the stability of the kainate receptor dimer interface, allowing proper activation of the receptor. Interestingly, a double cysteine mutation (Y521C/L783C GluK2) across the interface eliminates the need for occ

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Can Activation and Desensitization Properties of iGluRs Be Predicted and Understood by Studying the LBD Dimer Dynamics?

Autor: George B. Dawe, Maria Musgaard, Philip C. Biggin, Derek Bowie, Mark R. P. Aurousseau, Bryan A. Daniels

Publikováno v: Biophysical Journal. 108(2):287a-288a

Ionotropic glutamate receptors (iGluRs) are vital for the function of our central nervous system (CNS), e.g. in learning and memory formation, and thus implicated in many CNS disorders. The tetrameric iGluRs contain a glutamate-gated cation channel w

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Characterization of cys-loop receptor genes involved in inhibitory amine neurotransmission in parasitic and free living nematodes

Autor: George B. Dawe, Robin N. Beech, Vijayaraghava T.S. Rao, Micah K. Callanan, Sean G. Forrester

Publikováno v: Parasitology international. 62(6)

We have isolated two genes, Hco-lgc-53 and Hco-mod-1, from the parasitic nematode Haemonchus contortus, which are orthologs of previously characterized genes that encode dopamine and serotonin-gated chloride channels, respectively, in Caenorhabditis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2c3c472a93f8315960bdcb81a4845d
https://pubmed.ncbi.nlm.nih.gov/23602737

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