Zobrazeno 1 - 6
of 6
pro vyhledávání: '"George Appiah-Kubi"'
Autor:
Ashweta Sahni, George Appiah Kubi, Ziqing Qian, Jian-Guo Ren, Amritendu Koley, Patrick G Dougherty, Jin Wen, Ruchira Basu, Xiaoyan Pan, Dehua Pei, Heba Salim
Publikováno v:
J Med Chem
Stapled peptides recapitulate the binding affinity and specificity of α-helices in proteins, resist proteolytic degradation, and may provide a novel modality against challenging drug targets such as protein-protein interactions. However, most of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8209ea802cefe2b26a8c964426c9034b
https://doi.org/10.1021/acs.jmedchem.9b00456
https://doi.org/10.1021/acs.jmedchem.9b00456
Autor:
George Appiah Kubi, Dehua Pei
Publikováno v:
Methods Enzymol
The mitochondrion performs critical roles in eukaryotic cells including ATP production, cell growth, survival, apoptosis, and differentiation. Many human diseases can be traced to dysfunction within the mitochondria, but selective delivery of therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77557e0af12c1ac80cf9acfaefdb714
https://europepmc.org/articles/PMC7502014/
https://europepmc.org/articles/PMC7502014/
Autor:
George Appiah Kubi, Dehua Pei
Publikováno v:
Expert Opin Drug Discov
Introduction: Combinatorial chemistry provides a cost-effective method for rapid discovery of drug hits/leads. The one-bead-one-compound (OBOC) library method is in principle ideally suited for this application, because it permits a large number of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f971e33bfca5e4de3cc47c779f7f105f
https://pubmed.ncbi.nlm.nih.gov/31335229
https://pubmed.ncbi.nlm.nih.gov/31335229
Publikováno v:
Methods Mol Biol
Methods in Molecular Biology ISBN: 9781493995035
Methods in Molecular Biology ISBN: 9781493995035
Peptides provide an attractive modality for targeting challenging drug targets such as intracellular protein-protein interactions. Unfortunately, peptides are generally impermeable to the cell membrane and inherently susceptible to proteolytic degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910f97ad28d2b2af4501653034f8e57e
https://pubmed.ncbi.nlm.nih.gov/31134566
https://pubmed.ncbi.nlm.nih.gov/31134566
Autor:
Jin Wen, Ziqing Qian, Lucas C. McCroskey, George Appiah-Kubi, Dehua Pei, David J. Wang, Curran A. Rhodes, Denis C. Guttridge
Publikováno v:
Angewandte Chemie. 129:1547-1551
Therapeutic applications of peptides are currently limited by their proteolytic instability and impermeability to the cell membrane. A general, reversible bicyclization strategy is now reported to increase both the proteolytic stability and cell perm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddbb3e6e5017dadb174d16c2e26234e8
https://doi.org/10.1002/ange.201610888
https://doi.org/10.1002/ange.201610888
Autor:
Ziqing Qian, Ryan L. Hard, George Appiah-Kubi, Mitch A. Phelps, Dehua Pei, Jiang Wang, Jeremy S. Rossman, Agnieszka Martyna, Christopher C. Coss
Publikováno v:
Biochemistry
Previous cell-penetrating peptides (CPPs) generally have low cytosolic delivery efficiencies, because of inefficient endosomal escape. In this study, a family of small, amphipathic cyclic peptides was found to be highly efficient CPPs, with cytosolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb52edead4d8e4f0a4608bd5c9d6b3c0
https://pubmed.ncbi.nlm.nih.gov/27089101
https://pubmed.ncbi.nlm.nih.gov/27089101