Zobrazeno 1 - 10
of 13
pro vyhledávání: '"George Anis Sarkis"'
Autor:
Zhihui Yang, Rawad Daniel Arja, Tian Zhu, George Anis Sarkis, Robert Logan Patterson, Pammela Romo, Disa S. Rathore, Ahmed Moghieb, Susan Abbatiello, Claudia S. Robertson, William E. Haskins, Firas Kobeissy, Kevin K. W. Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 8960 (2022)
Glial fibrillary acidic protein (GFAP) is the major intermediate filament III protein of astroglia cells which is upregulated in traumatic brain injury (TBI). Here we reported that GFAP is truncated at both the C- and N-terminals by cytosolic proteas
Externí odkaz:
https://doaj.org/article/66233b88fd374c45bfe9a711bea3e48f
Autor:
Xue Li, Tian Zhu, Richard Rubenstein, Kevin K.W. Wang, Richard A Yost, Yuan Shi, Zhihui Yang, George Anis Sarkis, Geoffrey T. Manley
Publikováno v:
Biomark Med
Aim: There is a critical need to validate biofluid-based biomarkers as diagnostic and drug development tools for traumatic brain injury (TBI). As part of the TBI Endpoints Development Initiative, we identified four potentially predictive and pharmaco
Autor:
Nicholas J. Lees-Gayed, William E. Haskins, Joseph Banoub, Kevin K.W. Wang, Susan E Abbatielo, Claudia S. Robertson, Richard A Yost, George Anis Sarkis
Publikováno v:
Molecular Neurobiology. 59:731-747
Traumatic brain injury (TBI) is a major neurological disorder without FDA-approved therapies. In this study, we have examined the concept that TBI might trigger global brain proteolysis in the acute post-injury phase. Thus, we conducted a systemic pr
Autor:
Janice S. Gilsdorf, Zhihui Yang, Bharani Thangavelu, Claudia S. Robertson, Deborah A. Shear, Kevin K.W. Wang, George Anis Sarkis, Vivian Hook, Brittany N Abbatiello, Gregory Hook, J. Steven Jacobsen, Angela M. Boutté
Publikováno v:
J Neurotrauma
Cathepsin B (CatB), a lysosomal cysteine protease, is important to brain function and may have dual utility as a peripheral biomarker of moderate-severe traumatic brain injury (TBI). The present study determined levels of pro- and mature (mat) CatB p
Autor:
George Anis, Sarkis, Nicholas, Lees-Gayed, Joseph, Banoub, Susan E, Abbatielo, Claudia, Robertson, William E, Haskins, Richard A, Yost, Kevin K W, Wang
Publikováno v:
Molecular neurobiology. 59(2)
Traumatic brain injury (TBI) is a major neurological disorder without FDA-approved therapies. In this study, we have examined the concept that TBI might trigger global brain proteolysis in the acute post-injury phase. Thus, we conducted a systemic pr
The pathobiology of tau protein in traumatic brain injury (TBI) has spiked a great interest due to its role in existing neurodegenerative diseases and aging. Tau supports microtubule structural stability of axons and is altered in neurodegeneration,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc35a591ab27c919e5e571752a7fbc99
https://doi.org/10.1016/b978-0-12-816346-7.00028-2
https://doi.org/10.1016/b978-0-12-816346-7.00028-2
Autor:
Joseph Banoub, Nicolas Laurent, Basem Kanawati, George Anis Sarkis, Wael L. L. Demian, Paolo Piazzetta, Edward Randell, Celine Vaillant, Gianluca Giorgi, Travis D. Fridgen, Dominique Lafont
Publikováno v:
Rapid Communications in Mass Spectrometry. 29:1717-1732
RATIONALE This study examines the electrospray ionization mass spectrometry (ESI-MS), in-source collision-induced dissociation (CID) fragmentation and low-energy collision-induced dissociation tandem mass spectrometry (CID-MS/MS) of a synthetic pair
Publikováno v:
Expert opinion on therapeutic targets. 21(6)
Since its discovery as a major CNS-abundant protein 25 years ago, Ubiquitin C-terminal hydrolase-L1 (UCH-L1) has emerged as an important enzyme in regulating brain protein metabolism, by coupling to the proteasome pathway of protein degradation. Area
Autor:
Brian Lelling, Kevin K.W. Wang, George Anis Sarkis, Michael Guertin, Zhihui Yang, Manasi D. Mangaonkar, Firas Kobeissy, Ahmed Moghieb, Hamad Yadikar
Publikováno v:
Current neurology and neuroscience reports. 17(3)
Traumatic brain injury (TBI) and traumatic spinal cord injury (SCI), collectively termed neurotrauma, are two parallel neurological conditions that can cause long-lasting neurological impairment and other comorbidities in patients, while at the same
Autor:
Ahmed Moghieb, Dhwani Kumar, Firas Kobeissy, Vijaya Raghavan, George Anis Sarkis, Zhihui Yang, Kevin K.W. Wang, Rachna Manek
Publikováno v:
Molecular Neurobiology. 55:6129-6129
The original version of this article unfortunately contained a typographical error on Author’s name “Firas Kobessiy”. This should be corrected as “Firas Kobeissy”.