Zobrazeno 1 - 10
of 22
pro vyhledávání: '"George Andrew Freeman"'
Autor:
G S Lowell, John Milton, David I. Stuart, Joseph H. Chan, George Andrew Freeman, S S Gonzales, Steven A. Short, Jingshan Ren, Andrew L. Hopkins, K L Creech, Richard J. Hazen, R G Ferris, G W Koszalka, L T Schaller, G B Roberts, Cowan, C W Andrews Iii, Kurt Weaver, L R Boone, David K. Stammers, D J Reynolds
HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of the combination therapy currently used to treat HIV infection. The features of a new NNRTI drug for HIV treatment must include selective potent activity against both wild-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba0381a0617d10120e121697f22e025
https://doi.org/10.1021/jm040072r
https://doi.org/10.1021/jm040072r
Autor:
Matthew David Tallant, Wieslaw M. Kazmierski, Pat Wheelan, Maosheng Duan, George Andrew Freeman, Mark P. Edelstein, Robert G. Ferris
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1394-1398
We describe the synthesis and potency of a novel series of N-substituted 2-phenyl- and 2-methyl-2-phenyl-1,4-diaminobutane- based CCR5 antagonists. Compounds 7a and 12f were found to be potent in anti-HIV assays and bioavailable in the low-dose rat P
Autor:
George Andrew Freeman, Brian A. Johns, Scott H. Allen, Kelly R. Moniri, Katrina L. Creech, Connie H. Sexton, F. Leslie Boyd, Kristjan S. Gudmundsson, Dean W. Selleseth
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:944-954
A novel series of potent C-6 substituted pyrazolo[1,5-a]pyridine inhibitors of herpes simplex viruses has been identified. A synthetic methodology was developed involving functionalization of a C-6 trifluoromethyl pyrazolo[1,5-a]pyridine to allow fac
Autor:
Jeffrey H. Tidwell, George Andrew Freeman, Marty St. Clair, Robert G. Ferris, Lee T. Schaller, Dean W. Selleseth, Steven A. Short, Jill R. Cowan, Lawrence R. Boone, Kurt Weaver, G B Roberts, Joseph H. Chan, Richard J. Hazen, Kelly R. Moniri, Karen Rene Romines
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:4046-4051
The compound GW678248 is a novel benzophenone nonnucleoside reverse transcriptase inhibitor (NNRTI). Preclinical assessment of GW678248 indicates that this compound potently inhibits wild-type (WT) and mutant human immunodeficiency virus type 1 (HIV-
Autor:
George Andrew Freeman, Vicente Samano, F. Leslie Boyd, Brian A. Johns, Scott H. Allen, Kelly R. Moniri, Connie J. Sexton, John A. Ray, Katrina L. Creech, Dean W. Selleseth, Kristjan S. Gudmundsson, Elizabeth M. Turner
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:2397-2411
A novel series of potent pyrazolo[1,5-a]pyridine inhibitors of herpes simplex virus 1 replication have been identified. Several complimentary synthetic methods were developed to allow facile access to a diverse set of analogs from common late stage i
Publikováno v:
Journal of Medicinal Chemistry. 43:2473-2478
The metabolic instability in vivo of the glycosidic bond of 2,5, 6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole (TCRB) prompted us to design and synthesize the hitherto unreported fluorinated benzimidazole nucleosides 2,5, 6-trichloro-1-(2-deoxy-2
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:155-174
2,5,6-Trihalogenated benzimidazole-β-D-ribofuranosyl nucleosides and 2-substituted amino-5,6-dichlorobenzimidazole-β-L-ribofuranosyl nucleosides are potent and selective inhibitors of human cytomegalovirus (HCMV). The D-ribofuranosyl analogs are me
Autor:
Ruiming Zou, Etsuko Kawashima, Leroy B. Townsend, John C. Drach, George Andrew Freeman, George W. Koszalka
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:125-153
Stereoselective glycosylation of 2,5,6-trichlorobenzimidazole (1b), 2-bromo-5,6-dichlorobenzimidazole (1c), 5,6-dichlorobenzimidazole (1d), 5,6-dichlorobenzimidazole-2-thione (1e), 5,6-dichloro-2-(methylthio)benzimidazole (1f), 2-(benzylthio)-5,6-dic
Autor:
Nanine A. VanDraanen, George Andrew Freeman, Ann Aulabaugh, Wayne H. Miller, George R. Painter, Lawrence R. Boone, Boyd Frank Leslie, Susan Mary Daluge, Jeanne E. Wilson, Michelle G. Davis
Publikováno v:
Antiviral Research. 30:133-145
DNA polymerase activity was assayed in hepatitis B virus (HBV) and core particles isolated from chronic producer lines. The particle-associated DNA polymerase activity, which was found to be limited to incorporation of only a few nucleotides, was inh
Autor:
George Andrew Freeman, G. Szczech, George W. Koszalka, Steven A. Short, N. A. Van Draanen, Robert J. Harvey, Robert Jansen
Publikováno v:
Journal of Medicinal Chemistry. 39:538-542
A series of 2'-deoxy-4'-thioribo purine nucleosides was prepared by trans-N-deoxyribosylase-catalyzed reaction of 2'-deoxy-4'-thiouridine with a variety of purine bases. This synthetic procedure is an improvement over methods previously used to prepa