Zobrazeno 1 - 10
of 74
pro vyhledávání: '"George A. Small"'
Autor:
George W. Small, Farida S. Akhtari, Adrian J. Green, Tammy M. Havener, Michael Sikes, Julia Quintanhila, Ricardo D. Gonzalez, David M. Reif, Alison A. Motsinger-Reif, Howard L. McLeod, Tim Wiltshire
Publikováno v:
Cells, Vol 12, Iss 12, p 1574 (2023)
Monoclonal antibody (mAb) therapy directed against CD20 is an important tool in the treatment of B cell disorders. However, variable patient response and acquired resistance remain important clinical challenges. To identify genetic factors that may i
Externí odkaz:
https://doaj.org/article/fc45090c563c425fbc7ecb27e7e70be1
Autor:
Ricardo D. Gonzalez, George W. Small, Adrian J. Green, Farida S. Akhtari, Tammy M. Havener, Julia C. F. Quintanilha, Amber B. Cipriani, David M. Reif, Howard L. McLeod, Alison A. Motsinger-Reif, Tim Wiltshire
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 726 (2023)
Temozolomide (TMZ) chemotherapy is an important tool in the treatment of glioma brain tumors. However, variable patient response and chemo-resistance remain exceptionally challenging. Our previous genome-wide association study (GWAS) identified a sug
Externí odkaz:
https://doaj.org/article/57e65b5154c4450e9438e8a07a74bd2b
Autor:
Ricardo D. Gonzalez, George W. Small, Adrian J. Green, Farida S. Akhtari, Alison A. Motsinger-Reif, Julia C. F. Quintanilha, Tammy M. Havener, David M. Reif, Howard L. McLeod, Tim Wiltshire
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 757 (2023)
Oxaliplatin (OXAL) is a commonly used chemotherapy for treating colorectal cancer (CRC). A recent genome wide association study (GWAS) showed that a genetic variant (rs11006706) in the lncRNA gene MKX-AS1 and partnered sense gene MKX could impact the
Externí odkaz:
https://doaj.org/article/8aa3c245cb8d4f288b8d1ffcb9ff9422
Autor:
Farida S Akhtari, Adrian J Green, George W Small, Tammy M Havener, John S House, Kyle R Roell, David M Reif, Howard L McLeod, Timothy Wiltshire, Alison A Motsinger-Reif
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009732 (2021)
Cancer patients exhibit a broad range of inter-individual variability in response and toxicity to widely used anticancer drugs, and genetic variation is a major contributor to this variability. To identify new genes that influence the response of 44
Externí odkaz:
https://doaj.org/article/f1416aa594d345ff9d7fa52334c49271
Autor:
Michael P. Conlin, Dylan A. Reid, George W. Small, Howard H. Chang, Go Watanabe, Michael R. Lieber, Dale A. Ramsden, Eli Rothenberg
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2810-2819 (2017)
Nonhomologous end joining (NHEJ) must adapt to diverse end structures during repair of chromosome breaks. Here, we investigate the mechanistic basis for this flexibility. DNA ends are aligned in a paired-end complex (PEC) by Ku, XLF, XRCC4, and DNA l
Externí odkaz:
https://doaj.org/article/baede8a17e8942cf9e2845c01cef8eab
Autor:
Wiltshire, George W. Small, Farida S. Akhtari, Adrian J. Green, Tammy M. Havener, Michael Sikes, Julia Quintanhila, Ricardo D. Gonzalez, David M. Reif, Alison A. Motsinger-Reif, Howard L. McLeod, Tim
Publikováno v:
Cells; Volume 12; Issue 12; Pages: 1574
Monoclonal antibody (mAb) therapy directed against CD20 is an important tool in the treatment of B cell disorders. However, variable patient response and acquired resistance remain important clinical challenges. To identify genetic factors that may i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::60218ec289bf97ce7c7fd0873c0f1f70
Autor:
Robert Z. Orlowski, Jeffrey A. Nemeth, Mohamed H. Zaki, Robert E. Corringham, John S. Strader, Sally A. Hunsucker, George W. Small, Deborah J. Kuhn, Qing Chen, Peter M. Voorhees
Supplementary Figures S1-S2 from Inhibition of Interleukin-6 Signaling with CNTO 328 Enhances the Activity of Bortezomib in Preclinical Models of Multiple Myeloma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cb5a93a68b7c601b04c11251e135b5
https://doi.org/10.1158/1078-0432.22439319
https://doi.org/10.1158/1078-0432.22439319
Autor:
Robert Z. Orlowski, Jeffrey A. Nemeth, Mohamed H. Zaki, Robert E. Corringham, John S. Strader, Sally A. Hunsucker, George W. Small, Deborah J. Kuhn, Qing Chen, Peter M. Voorhees
Purpose: Inhibition of the proteasome leads to the activation of survival pathways in addition to those that promote cell death. We hypothesized that down-regulation of interleukin-6 (IL-6) signaling using the monoclonal antibody CNTO 328 would enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8da62fc2c8443f5d600227f1aa2f6a
https://doi.org/10.1158/1078-0432.c.6516807.v1
https://doi.org/10.1158/1078-0432.c.6516807.v1
Supplementary Figure 3 from Mitogen-Activated Protein Kinase Phosphatase-1 Is a Mediator of Breast Cancer Chemoresistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4e43b1e475a6504a7410426d654eb3
https://doi.org/10.1158/0008-5472.22368294.v1
https://doi.org/10.1158/0008-5472.22368294.v1
Supplementary Figure 1 from Mitogen-Activated Protein Kinase Phosphatase-1 Is a Mediator of Breast Cancer Chemoresistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925373acaf33839cda22be645867677f
https://doi.org/10.1158/0008-5472.22368300.v1
https://doi.org/10.1158/0008-5472.22368300.v1