Zobrazeno 1 - 10
of 36
pro vyhledávání: '"George A. Scheele"'
Publikováno v:
Journal of Surgical Research. 105:136-144
Background. Pancreatic stone protein (PSP/ reg ) is a constitutively secreted protein in pancreatic juice. Pancreatitis-associated protein (PAP) belongs to the same family of proteins. PAP is highly increased during acute pancreatitis, while no exact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9de422c907b526892b01bffd328fc42
https://doi.org/10.1006/jsre.2002.6387
https://doi.org/10.1006/jsre.2002.6387
Publikováno v:
European Journal of Cell Biology. 75:163-173
Using rat pancreatic acini, we have recently shown that apical endocytosis is inhibited at pH 6.0 and progressively activated as the pH is increased to 8.3. Endocytotic activity correlated with the release of GP2, a GPI-linked protein, from the apica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6aed150a99ffca8c72218d1cc006e66
https://doi.org/10.1016/s0171-9335(98)80058-7
https://doi.org/10.1016/s0171-9335(98)80058-7
Publikováno v:
Journal of Biological Chemistry. 272:3073-3082
Apart from digestive enzymes, pancreatic juice contains several proteins that are not directly involved in digestion. One of these, lithostathine, has been reported to exhibit calcite crystal inhibitor activity in vitro. As pancreatic juice is supers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c7596a40dede621a47a91355806180
https://doi.org/10.1074/jbc.272.5.3073
https://doi.org/10.1074/jbc.272.5.3073
Publikováno v:
Pancreas. 11:63-76
We have constructed a recombinant baculovirus expression vector containing rat pancreatic lithostatin cDNA. Baculovirus infection of Spodoptera frugiperda (sf9) insect cells resulted in the de novo synthesis and secretion of a recombinant protein dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151047ce4195b1034399b9fae5326368
https://doi.org/10.1097/00006676-199507000-00007
https://doi.org/10.1097/00006676-199507000-00007
Publikováno v:
Journal of Biological Chemistry. 269:7464-7472
The endoplasmic reticulum (ER) not only links the translational machinery to the endomembrane system in eukaryotic cells but also provides a protective environment for the folding of exoplasmic proteins translocated across the ER membrane. Here we de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0529c4a75926535bd72e7ab77214007d
https://doi.org/10.1016/s0021-9258(17)37309-x
https://doi.org/10.1016/s0021-9258(17)37309-x
Publikováno v:
Pancreas. 9:139-149
Identification and characterization of the GP2/THP family of GPI-anchored membrane proteins associated with apical secretory membranes suggest that this new class of GPI-linked proteins plays a critical role in regulated protein secretion and ion tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efca4f0b951bc5a1129ff0bb76611710
https://doi.org/10.1097/00006676-199403000-00001
https://doi.org/10.1097/00006676-199403000-00001
Publikováno v:
Proceedings of the National Academy of Sciences. 88:2898-2902
GP-2, a 75-kDa glycoprotein, was isolated from dog pancreatic zymogen granule membranes (ZGMs). In a carbohydrate-shift strategy, N-terminal and internal peptide sequences were obtained on glycosylated and deglycosylated forms of GP-2, respectively,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb072dc20ed9f199614d87e7298ad30
https://doi.org/10.1073/pnas.88.7.2898
https://doi.org/10.1073/pnas.88.7.2898
Autor:
Rolf Graf, Marc Schiesser, Eliane Angst, George A. Scheele, Aurel Perren, Rudolf W. Ammann, Severin Meili, Daniel Bimmler
Publikováno v:
The Journal of surgical research. 118(2)
Background PSP/reg and PAP are secretory stress proteins (SSP) and may be part of a protective mechanism. They share structural homologies and form insoluble fibrils after tryptic activation. To further explore the regulation of these proteins, we in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755829103dedd65d961c2d048150f432
https://pubmed.ncbi.nlm.nih.gov/15100001
https://pubmed.ncbi.nlm.nih.gov/15100001
Publikováno v:
Gastroenterology. 121(4)
Background & Aims: We have previously shown that endocytosis at the apical plasma membrane in pancreatic acinar cells is coupled to ductal bicarbonate secretion into the lumen. We hypothesized that decreased bicarbonate secretion in cystic fibrosis (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde216f67d378853416fa10b77640591
https://pubmed.ncbi.nlm.nih.gov/11606508
https://pubmed.ncbi.nlm.nih.gov/11606508
Autor:
Rolf Graf, Daniel Bimmler, George A. Scheele, Marc Schiesser, Thomas W. Frick, Klaus Marquardt, Rudolf W. Ammann
Publikováno v:
The Journal of biological chemistry
A group of 16-kDa proteins, synthesized and secreted by rat pancreatic acinar cells and composed of pancreatic stone protein (PSP/reg) and isoforms of pancreatitis-associated protein (PAP), show structural homologies, including conserved amino acid s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4e8db4a78b33dd35ca1c8181032538
https://pubmed.ncbi.nlm.nih.gov/11278730
https://pubmed.ncbi.nlm.nih.gov/11278730