Zobrazeno 1 - 10
of 279
pro vyhledávání: '"George A. Porter"'
Autor:
Marlee M. Vandewouw, Ami Norris-Brilliant, Anum Rahman, Stephania Assimopoulos, Sarah U. Morton, Azadeh Kushki, Sean Cunningham, Eileen King, Elizabeth Goldmuntz, Thomas A. Miller, Nina H. Thomas, Heather R. Adams, John Cleveland, James F. Cnota, P Ellen Grant, Caren S. Goldberg, Hao Huang, Jennifer S. Li, Patrick McQuillen, George A. Porter, Amy E. Roberts, Mark W. Russell, Christine E. Seidman, Madalina E. Tivarus, Wendy K. Chung, Donald J. Hagler, Jane W. Newburger, Ashok Panigrahy, Jason P Lerch, Bruce D. Gelb, Evdokia Anagnostou
Publikováno v:
NeuroImage, Vol 297, Iss , Pp 120721- (2024)
Individuals with congenital heart disease (CHD) have an increased risk of neurodevelopmental impairments. Given the hypothesized complexity linking genomics, atypical brain structure, cardiac diagnoses and their management, and neurodevelopmental out
Externí odkaz:
https://doaj.org/article/5e44b9017eb64e49ae2ee4fa20bd3328
Autor:
Lara Maleyeff, Jane W. Newburger, David Wypij, Nina H. Thomas, Evdokia Anagnoustou, Martina Brueckner, Wendy K. Chung, John Cleveland, Sean Cunningham, Bruce D. Gelb, Elizabeth Goldmuntz, Donald J Hagler Jr, Hao Huang, Eileen King, Patrick McQuillen, Thomas A. Miller, Ami Norris‐Brilliant, George A. Porter Jr, Amy E. Roberts, P. Ellen Grant, Kiho Im, Sarah U. Morton
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 2, Pp 278-290 (2024)
Abstract Objective Persons with congenital heart disease (CHD) are at increased risk of neurodevelopmental disabilities, including impairments to executive function. Sulcal pattern features correlate with executive function in adolescents with single
Externí odkaz:
https://doaj.org/article/8dcae0435919402c9b79af51bd1ffc3c
Autor:
Gisela Beutner, Jonathan Ryan Burris, Michael P. Collins, Chaitanya A. Kulkarni, Sergiy M. Nadtochiy, Karen L. de Mesy Bentley, Ethan D. Cohen, Paul S. Brookes, George A. Porter, Jr.
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109157- (2024)
Summary: In the embryonic heart, the activation of the mitochondrial electron transport chain (ETC) coincides with the closure of the cyclophilin D (CypD) regulated mitochondrial permeability transition pore (mPTP). However, it remains to be establis
Externí odkaz:
https://doaj.org/article/a462e368f5ea459999c5d9156d652a7f
Autor:
John O. Onukwufor, M. Arsalan Farooqi, Anežka Vodičková, Shon A. Koren, Aksana Baldzizhar, Brandon J. Berry, Gisela Beutner, George A. Porter, Vsevolod Belousov, Alan Grossfield, Andrew P. Wojtovich
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Mitochondria regulate diverse cellular signalling processes in addition to producing energy. Here, the authors show a mitochondrial redox switch that, when activated, helps nematode worms sense conditions of low environmental oxygen.
Externí odkaz:
https://doaj.org/article/0ca5eb3f762f416595118bd779d947f4
Autor:
Alexander Hsieh, Sarah U. Morton, Jon A. L. Willcox, Joshua M. Gorham, Angela C. Tai, Hongjian Qi, Steven DePalma, David McKean, Emily Griffin, Kathryn B. Manheimer, Daniel Bernstein, Richard W. Kim, Jane W. Newburger, George A. Porter, Deepak Srivastava, Martin Tristani-Firouzi, Martina Brueckner, Richard P. Lifton, Elizabeth Goldmuntz, Bruce D. Gelb, Wendy K. Chung, Christine E. Seidman, J. G. Seidman, Yufeng Shen
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-18 (2020)
Abstract Background The contribution of somatic mosaicism, or genetic mutations arising after oocyte fertilization, to congenital heart disease (CHD) is not well understood. Further, the relationship between mosaicism in blood and cardiovascular tiss
Externí odkaz:
https://doaj.org/article/b7f196ef4fc94a1c9c9e2a38f2b299d7
Autor:
Ethan David Cohen, Min Yee, George A. Porter Jr., Erin Ritzer, Andrew N. McDavid, Paul S. Brookes, Gloria S. Pryhuber, Michael A. O’Reilly
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Preterm birth increases the risk for pulmonary hypertension and heart failure in adulthood. Oxygen therapy can damage the immature cardiopulmonary system and may be partially responsible for the cardiovascular disease in adults born preterm. We previ
Externí odkaz:
https://doaj.org/article/52549453edfd42f29d70d399ca47d15f
Autor:
George A. Porter, Gisela Beutner
Publikováno v:
Biomolecules, Vol 8, Iss 4, p 176 (2018)
Cyclophilin D (CyPD) is an important mitochondrial chaperone protein whose mechanism of action remains a mystery. It is well known for regulating mitochondrial function and coupling of the electron transport chain and ATP synthesis by controlling the
Externí odkaz:
https://doaj.org/article/fa877d5b509841e7b3e85a28c060e2b8
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Accepted features of neurodegenerative disease include mitochondrial and protein folding dysfunction and activation of pro-death factors. Neurons that experience high metabolic demand or those found in organisms with genetic mutations in proteins tha
Externí odkaz:
https://doaj.org/article/76dd98fe0bf94902b140f12262d8993e
Autor:
Rubens Sautchuk, Chen Yu, Matthew McArthur, Christine Massie, Paul S. Brookes, George A. Porter, Hani Awad, Roman A. Eliseev
Publikováno v:
Journal of Bone and Mineral Research. 38:522-540
Autor:
Chiemela Ohanele, Jessica N. Peoples, Anja Karlstaedt, Joshua T. Geiger, Ashley D. Gayle, Nasab Ghazal, Fateemaa Sohani, Milton E. Brown, Michael E. Davis, George A. Porter, Victor Faundez, Jennifer Q. Kwong
Publikováno v:
bioRxiv
SUMMARYThe developing mammalian heart undergoes an important metabolic shift from glycolysis toward mitochondrial oxidation, such that oxidative phosphorylation defects may present with cardiac abnormalities. Here, we describe a new mechanistic link
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a2cbc42720c6b9b22abd05bb2deb36
https://doi.org/10.1101/2023.05.22.541833
https://doi.org/10.1101/2023.05.22.541833