Zobrazeno 1 - 10
of 35
pro vyhledávání: '"George A. Moniz"'
Autor:
Chaomin Li, Yiqing Lin, John Guzowski, Lloyd Franklin, Brian T. Hopkins, Michael MacPhee, Daniel Patience, Bin Ma, Zheng Fengmei, Michael Humora, Robbie Chen, Erin M. O’Brien, George A. Moniz, William F. Kiesman, Steven Ferguson, Tamera Mack
Publikováno v:
Organic Process Research & Development. 24:1199-1206
Chemical process development efforts leading to multikilogram production of BIIB068 hemiadipate are discussed. Process optimization resulted in (1) removal of transition metal from the process, (2)...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7697bd2139a22f282f464a8ae16c611
https://doi.org/10.1021/acs.oprd.0c00087
https://doi.org/10.1021/acs.oprd.0c00087
Autor:
Francis G. Fang, Kazuhiro Yoshizawa, Atsushi Kamada, Taiju Nakamura, Masaaki Matsuda, Katsuya Tagami, Nobuaki Sato, Takeo Sasaki, Yongbo Hu, George A. Moniz, Minetaka Isomura, Yoshihiro Nishikawa, Gordon D. Wilkie, Daiju Hasegawa, Yorihisa Hoshino, Kazato Inanaga, Toshiyuki Uemura
Publikováno v:
Organic Process Research & Development. 23:603-613
Process studies of E2212 (1) toward rapid clinical introduction are described. Through comprehensive route-finding studies and optimization of key condensation and cyclization steps, a racemate-based manufacturing route was established and successful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46a6b7869f9ea3690bb1a0225426216e
https://doi.org/10.1021/acs.oprd.8b00444
https://doi.org/10.1021/acs.oprd.8b00444
Autor:
Kenichi Nomoto, Kuan-Chun Huang, Donna Kolber-Simonds, Natalie C. Twine, George A. Moniz, Paul Chang, Jue-lon Shie, Jingzang Tao Miu, Karen Ackermann, Zhihong Chen, Sharon McGonigle, Jiayi Wu
Publikováno v:
Oncotarget
Impact Journals/National Center for Biotechnology Information (U.S.)
Impact Journals/National Center for Biotechnology Information (U.S.)
Inhibition of Poly(ADP-ribose) Polymerase1 (PARP1) impairs DNA damage repair, and early generation PARP1/2 inhibitors (olaparib, niraparib, etc.) have demonstrated clinical proof of concept for cancer treatment. Here, we describe the development of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e06e5b24d95dc69ae605cc8d13662cf
https://doi.org/10.18632/oncotarget.5846
https://doi.org/10.18632/oncotarget.5846
Autor:
Steven Mathieu, George A. Moniz
Publikováno v:
Tetrahedron Letters. 55:5855-5858
A bromination process has been developed using a salt-based brominating reagent and a non-chlorinated solvent system. The process affords enhanced selectivity and enables product isolation by simple filtration of the reaction mixture, resulting in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55977d2c6416c066fa102ec4cb52079b
https://doi.org/10.1016/j.tetlet.2014.08.094
https://doi.org/10.1016/j.tetlet.2014.08.094
Cope elimination mediated by human FMO1 leads to formation of reactive Michael Acceptor intermediate
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S58
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33f25680ded954154106e65a9402c69f
https://doi.org/10.1016/j.dmpk.2018.09.204
https://doi.org/10.1016/j.dmpk.2018.09.204
Publikováno v:
Tetrahedron Letters. 52:5613-5616
The diastereoselective alkylation of a series of 5-alkyl-2-aminothiazolones utilizing a C 2 -symmetric chiral tetraamine base is reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8846e886c69dd2f80f1761306216422
https://doi.org/10.1016/j.tetlet.2011.08.073
https://doi.org/10.1016/j.tetlet.2011.08.073
Publikováno v:
Drug Metabolism and Disposition. 39:61-70
10-((4-Hydroxypiperidin-1-yl)methyl)chromeno[4,3,2-de]phthalazin-3(2H)-one (E7016), an inhibitor of poly(ADP-ribose) polymerase, is being developed for anticancer therapy. One of the major metabolites identified in preclinical animal studies was the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb06748a477177e882470acbba4609d0
https://doi.org/10.1124/dmd.110.035360
https://doi.org/10.1124/dmd.110.035360
Autor:
Clarence Hale, Martin Henriksson, Randall W. Hungate, Renee Komorowski, Kyung H. Gahm, Jiandong Zhang, Murielle M. Véniant, Janan Jona, Vivian S. W. Li, Andrew Hague, Maurice Emery, Christopher H. Fotsch, Steven R. Jordan, Smriti Joseph, David J. St. Jean, Lars Johansson, Minghan Wang, Rashid Syed, Jeffrey Adams, George A. Moniz, Rod Cupples, Ki Won Kim, Michael D. Bartberger, Jerk Vallgarda, Michelle Chen, Meredith Williams
Publikováno v:
Journal of Medicinal Chemistry. 53:4481-4487
Thiazolones with an exo-norbornylamine at the 2-position and an isopropyl group on the 5-position are potent 11beta-HSD1 inhibitors. However, the C-5 center was prone to epimerization in vitro and in vivo, forming a less potent diastereomer. A methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe379e52733a44c74ee775e8c1cbc9ee
https://doi.org/10.1021/jm100242d
https://doi.org/10.1021/jm100242d
Publikováno v:
Chirality. 22:50-55
The separation of R,R-, S,S-, and meso-Koga bases on derivatized amylose chiral stationary phases (CSP) has been studied using different alcohol and alcohol-hexane mixtures as eluant. Straight-chain and branched alcohols with carbon numbers from one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80de40d92379eced896b4a4372df4cb7
https://doi.org/10.1002/chir.20704
https://doi.org/10.1002/chir.20704
Autor:
James K. Lee, Pilar Franco, Geoffrey B. Cox, Kenichi Sakai, Jay Larrow, Karl B. Hansen, George A. Moniz, Saab Khattabi, Margaret M. Faul, Jerome Boni, Liane M. Klingensmith, Jason S. Tedrow, Michael J. Martinelli, Larry Miller, Seb Caille
Publikováno v:
Organic Process Research & Development. 14:133-141
Two routes aimed at the manufacture of chiral exo-2-norbornyl thiourea (1) on large scale are described. The first approach involves five chemical steps and hinges on a classical resolution via diastereomeric salt formation. The synthesis utilizes am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2cf952ff3741ee14500cd8a4a9f5a87
https://doi.org/10.1021/op9002328
https://doi.org/10.1021/op9002328