Výsledky vyhledávání - "George A. Lira"

Akademický článek

Retinoic acid-loaded PLGA nanocarriers targeting cell cholesterol potentialize the antitumour effect of PD-L1 antibody by preventing epithelial-mesenchymal transition mediated by M2-TAM in colorectal cancer

Autor: Raimundo Fernandes de Araújo Júnior, George A Lira, Timo Schomann, Rômulo S Cavalcante, Natalia Feitosa Vilar, Regina Célia Monteiro de Paula, Raelle Ferreira Gomes, Chih Kit Chung, Carla Jorquera-Cordero, Olena Vepris, Alan B Chan, Luis J. Cruz

Publikováno v: Translational Oncology, Vol 31, Iss , Pp 101647- (2023)

Tumour-associated macrophages (TAMs) often promote cancer progression through immunosuppression in the tumour microenvironment (TME). However, the signalling pathways crosstalk responsible for this mechanism remain unclear. The aim of our study was t

Externí odkaz: https://doaj.org/article/1ad0cf4f16454bd89fc185bf2a381c4e

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Akademický článek

Design of Cable Termination for AC Breakdown Voltage Tests

Autor: Arthur F. Andrade, Edson G. Costa, Filipe L.M. Andrade, Clarice S.H. Soares, George R.S. Lira

Publikováno v: Energies, Vol 12, Iss 16, p 3075 (2019)

International standards prescribe overvoltage tests to evaluate the insulating material performance of high-voltage cables. However, it is difficult to manage the electric fields at the cable ends when laboratory measurements are carried out because

Externí odkaz: https://doaj.org/article/e6618db40e2548b69b2f58a96d06c3a5

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Telmisartan decreases inflammation by modulating TNF-α, IL-10, and RANK/RANKL in a rat model of ulcerative colitis

Autor: Maryanne Nunes de Melo, Raimundo Fernandes de Araújo Júnior, George A. Lira, Aurigena Antunes de Araújo, Arthur L. Silva, Daline Fernandes, Gerlane Coelho Bernardo Guerra, Késia K.O. Souto

Publikováno v: Pharmacological Reports. 67:520-526

Telmisartan is an antihypertensive angiotensin II receptor blocker. This antihypertensive shows antiinflammatory activity.In this study, the antiinflammatory activity of telmisartan was tested in an acetic acid (10%) model of ulcerative colitis (UC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a558d788f7d93ea281cf7318706e5444
https://doi.org/10.1016/j.pharep.2014.12.011

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Influence of immune-checkpoint inhibitor and HLA-G in patients with Cervical Cancer

Autor: JANAINA C. O. CRISPIM-FREITAS, Rayanne S. P. Morais, Valéria S. Oliveira, Ibrahim Sadissou, Gustavo M. Palomino, Ricardo N. O. Cobucci, George A. Lira, Kleyton T. C. Carvalho, Emanuelly B. O. Silva, Norma L. Silva, Eduardo A. Donadi

Publikováno v: The Journal of Immunology. 202:136.10-136.10

A better understanding of the role of Immune checkpoint inhibitors (ICI) and immunoregulatory genes HLA-G is essential for the development of immunotherapeutic strategies in cancer. This study aims to evaluate the influence of CTLA-4, PD-1 and polymo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a4c06f64bcecc0c740d30ad13bc4f5f
https://doi.org/10.4049/jimmunol.202.supp.136.10

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Prognostic and diagnostic implications of MMP-2, MMP-9, and VEGF-α expressions in colorectal cancer

Autor: Hugo Gonçalo Guedes, M.C.A. Leitão, Carlos César de Oliveira Ramos, Raimundo Fernandes de Araújo, J.A. Vilaça, George A. Lira, H.F. Lucena

Publikováno v: Pathology, research and practice. 211(1)

Angiogenesis and tumor invasion are complex processes that are mediated by various proteins, such as vascular endothelial growth factor (VEGF-α) and the matrix-degrading enzymes metalloproteinase-2 and -9 (MMP-2, MMP-9). The aim of this study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f908ce69a181caefe4eb1c8aeb9399c
https://pubmed.ncbi.nlm.nih.gov/25446246

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Lifestyle and family history influence cancer prognosis in Brazilian individuals

Autor: Aurigena Antunes de Araújo, Hugo Gonçalo Guedes, George A. Lira, Francisco J. Cavalcante, Raimundo Fernandes de Araújo, Carlos César de Oliveira Ramos, Marília A. Cardoso, Ana Lucia M. Araújo

Publikováno v: Repositório Institucional da UFRN
Universidade Federal do Rio Grande do Norte (UFRN)
instacron:UFRN

The aim of this research was to study prognostic parameters of CRC by analyzing clinical and pathological variables associated with cancer patients at a northeastern Brazilian Hospital. This was a retrospective study evaluating CRC-diagnosed patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5c687ee5eac6e3d2e3754262b98e92
https://repositorio.ufrn.br/jspui/handle/123456789/25414