Zobrazeno 1 - 10
of 20
pro vyhledávání: '"George A. Krudy"'
Publikováno v:
Journal of Chemical Information and Modeling. 46:2674-2683
In this work, a genetic algorithm (GA) was applied to build up a set of QSPR (quantitative structure-property relationship) models for human absolute oral bioavailability, plasma protein binding, and urinary excretion using the counts of molecular fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87953bb51417679938d076752ca46843
https://doi.org/10.1021/ci060087t
https://doi.org/10.1021/ci060087t
Publikováno v:
Quantitative Structure-Activity Relationships. 18:124-133
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f22a8bbc4024a4ab5f1e5410a530a368
https://doi.org/10.1002/(sici)1521-3838(199906)18:2<124::aid-qsar124>3.0.co
https://doi.org/10.1002/(sici)1521-3838(199906)18:2<124::aid-qsar124>3.0.co
Autor:
Quinn Kleerekoper, R. J. Solaro, George A. Krudy, Paul R. Rosevear, Xiaodu Guo, J. W. Howarth
Publikováno v:
Journal of Biological Chemistry. 269:23731-23735
NMR spectroscopy and selective isotope labeling of both recombinant cardiac troponin C (cTnC3) and a truncated cardiac troponin I (cTnI/NH2) lacking the N-terminal 32-amino acid cardiac-specific sequence have been used to probe protein-protein intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76398f148109181295350287b9a129f8
https://doi.org/10.1016/s0021-9258(17)31576-4
https://doi.org/10.1016/s0021-9258(17)31576-4
Publikováno v:
Biochemistry. 33:398-402
The metal binding properties of isoleucyl-tRNA synthetase (IleRS) from Escherichia coli were studied by in vivo substitution of the enzyme-bound metals. Purified E. coli IleRS was shown to have two tightly bound zinc atoms per active site. Cobalt- an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09737759b8da195d2bb7c67ed071c7e7
https://doi.org/10.1021/bi00168a002
https://doi.org/10.1021/bi00168a002
Publikováno v:
Journal of Biological Chemistry. 268:20966-20973
One- and two-dimensional NMR techniques were used to compare the structural consequences of Ca2+ binding to both the low and high affinity Ca2+ binding sites in recombinant cardiac troponin C (cTnC3). In the absence of Ca2+, the short beta-sheet loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d008785fc05959eef09b99423e747020
https://doi.org/10.1016/s0021-9258(19)36880-2
https://doi.org/10.1016/s0021-9258(19)36880-2
Publikováno v:
Journal of Biological Chemistry. 268:16259-16264
A truncated form of the methionyl-tRNA synthetase (delta MTS), which has been cloned, overproduced, and characterized, was used in an attempt to better understand the role of the enzyme-bound zinc in the amino-acylation process. Apo-, Zn(2+)-, Co(2+)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60c489d1856d794dd503bd4b104c20df
https://doi.org/10.1016/s0021-9258(19)85414-5
https://doi.org/10.1016/s0021-9258(19)85414-5
Autor:
F. Wold, S. H. Hixson, Ming-Chuan Shao, George A. Krudy, A. Flores-Carreon, Arnold D. Gomez, Paul R. Rosevear
Publikováno v:
Journal of Biological Chemistry. 265:754-759
When a derivatized oligosaccharide isolated from ovalbumin and containing 6 mannose residues was incubated with yeast membranes and GDP-mannose, two sets of products were obtained, a high molecular weight one containing about 25 mannose residues and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e18dc5234a26ee49df613cd66e1d7067
https://doi.org/10.1016/s0021-9258(19)40114-2
https://doi.org/10.1016/s0021-9258(19)40114-2
Publikováno v:
Journal of chemical information and modeling. 47(4)
In this work, two reliable aqueous solubility models, ASMS (aqueous solubility based on molecular surface) and ASMS-LOGP (aqueous solubility based on molecular surface using ClogP as a descriptor), were constructed by using atom type classified solve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750fe196d8b181550d9db3ec8a161c57
https://pubmed.ncbi.nlm.nih.gov/17569522
https://pubmed.ncbi.nlm.nih.gov/17569522
The paramagnetic relaxation reagent, 4-hydroxy-2,2,6,6-tetramethylpiperidinyl-1-oxy (HyTEMPO), was used to probe the surface exposure of methionine residues of recombinant cardiac troponin C (cTnC) in the absence and presence of Ca2+ at the regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b1dcb04f1f37da017a6d955170a3b5
https://europepmc.org/articles/PMC2143097/
https://europepmc.org/articles/PMC2143097/
Publikováno v:
Biochemistry. 33(48)
The 10 Met methyl groups in recombinant cardiac troponin (cTnC) were metabolically labeled with [13C-methyl]Met and detected as 10 individual cross-peaks using two-dimensional heteronuclear single- and multiple-quantum coherence (HSMQC) spectroscopy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1495554a4e0ac6ee4f2c4b6be35cfcc
https://pubmed.ncbi.nlm.nih.gov/7981203
https://pubmed.ncbi.nlm.nih.gov/7981203