Voltage-gated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Autor: Xiaoliang Wang, James S. Trimmer, Walter Stühmer, Michael C. Sanguinetti, Bernardo Rudy, Gail A. Robertson, Luis A. Pardo, Jeanne Nerbonne, David Mckinnon, Michel Lazdunski, Lily Y. Jan, George A. Gutman, Stephan Grissmer, M. Hunter Giese, K. George Chandy, Bernard Attali

Publikováno v: IUPHAR/BPS Guide to Pharmacology CITE, vol 2019, iss 4

The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92eb06f5b8beaf76a63bc4917b70ac8
https://escholarship.org/uc/item/1vf1p541

Voltage-gated potassium channels (Kv) in GtoPdb v.2023.1

Autor: Xiaoliang Wang, James S. Trimmer, Walter Stühmer, Michael C. Sanguinetti, Bernardo Rudy, Gail A. Robertson, Luis A. Pardo, Jeanne Nerbonne, David Mckinnon, Michel Lazdunski, Lily Y. Jan, George A. Gutman, Stephan Grissmer, M. Hunter Giese, K. George Chandy, Bernard Attali

Publikováno v: IUPHAR/BPS Guide to Pharmacology CITE. 2023

The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99aca55f8983c389a3f91071d3c86ebc
https://doi.org/10.2218/gtopdb/f81/2023.1

Voltage-gated potassium channels (Kv) in GtoPdb v.2021.3

Autor: Bernardo Rudy, Bernard Attali, Lily Yeh Jan, Xiaoliang Wang, M. Hunter Giese, James S. Trimmer, David McKinnon, George A. Gutman, Jeanne M. Nerbonne, Michel Lazdunski, Stephan Grissmer, Walter Stühmer, K. George Chandy, Gail A. Robertson, Luis A. Pardo, Michael C. Sanguinetti

Publikováno v: IUPHAR/BPS Guide to Pharmacology CITE. 2021

The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c9626dc18faf9d8624389fc9379b08c
https://doi.org/10.2218/gtopdb/f81/2021.3

Kv1.3 channel‐blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases

Autor: Vikas Dhawan, George K. Chandy, Satendra Chauhan, James D. Swarbrick, Shihchieh Jeff Chang, Mariel Gindin, Hai M. Nguyen, Luz M. Londono, Biswaranjan Mohanty, Rosendo Estrada, Sanjeev K. Upadhyay, Heike Wulff, Sandeep Chhabra, Mark R. Tanner, George A. Gutman, Jesus G. Valenzuela, Christine Beeton, Raymond S. Norton, Michael W. Pennington, Redwan Huq, Shawn P. Iadonato, Peter J. Hotez

Publikováno v: Chhabra, S; Chang, SC; Nguyen, HM; Huq, R; Tanner, MR; Londono, LM; et al.(2014). Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: Implications for autoimmune diseases. FASEB Journal, 28(9), 3952-3964. doi: 10.1096/fj.14-251967. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7263j9v0
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol 28, iss 9

© FASEB. The voltage-gated potassium (Kv) 1.3 channel is widely regarded as a therapeutic target for immunomodulation in autoimmune diseases. ShK-186, a selective inhibitor of Kv1.3 channels, ameliorates autoimmune diseases in rodent models, and hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156094e78816a581e3ee1acc175ae688
https://doi.org/10.1096/fj.14-251967

Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

Autor: Heike Wulff, Christine Beeton, Jamshid Tehranzadeh, Nathan Standifer, Stephen M Griffey, Werner W. Roeck, Christine J. LeeHealey, Philippe Azam, Brian S. Andrews, Alexandra Grino, Debra Counts, K. George Chandy, George A. Gutman, Kimber L. Stanhope, Ananthakrishnan Sankaranarayanan, Ping H. Wang, Katherine M. Mullen, Daniel Homerick, Pavel I. Zimin, Peter J. Havel, Michael W. Pennington, Aaron Kolski-Andreaco, Eric Wei, Peter A. Calabresi, Gerald T. Nepom, Hans Guenther Knaus

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 103, iss 46
Beeton, Christine; Wulff, Heike; Standifer, Nathan E; Azam, Philippe; Mullen, Katherine M; Pennington, Michael W; et al.(2006). Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.. Proceedings of the National Academy of Sciences of the United States of America, 103(46), 17414-17419. doi: 10.1073/pnas.0605136103. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/2647b9c5

Autoreactive memory T lymphocytes are implicated in the pathogenesis of autoimmune diseases. Here we demonstrate that disease-associated autoreactive T cells from patients with type-1 diabetes mellitus or rheumatoid arthritis (RA) are mainly CD4+CCR7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a931e3681163814cdfcb4dbd13625c82
https://doi.org/10.1073/pnas.0605136103