Zobrazeno 1 - 10
of 18
pro vyhledávání: '"George A. Gaitanaris"'
Autor:
Hongkui Zeng, Kyoji Horie, Linda Madisen, Maria N Pavlova, Galina Gragerova, Alex D Rohde, Brian A Schimpf, Yuqiong Liang, Ethan Ojala, Farah Kramer, Patricia Roth, Olga Slobodskaya, Io Dolka, Eileen A Southon, Lino Tessarollo, Karin E Bornfeldt, Alexander Gragerov, George N Pavlakis, George A Gaitanaris
Publikováno v:
PLoS Genetics, Vol 4, Iss 5, p e1000069 (2008)
Inducible and reversible regulation of gene expression is a powerful approach for uncovering gene function. We have established a general method to efficiently produce reversible and inducible gene knockout and rescue in mice. In this system, which w
Externí odkaz:
https://doaj.org/article/d20796b8c63140f2a6de21e85453e4cc
Autor:
Alex Rohde, Tim Sexton, Erik Espling, George A. Gaitanaris, Christiana Doulami, Alexander Gragerov, Marc A. Gavin
Publikováno v:
Cancer Immunology Research. 8:B45-B45
Extracellular phosphatidylserine (PS) is a potent modulator of immune responses. Various phospholipid scramblases respond to different cellular processes to expose PS either during apoptosis or during activation of multiple cell types, including plat
Autor:
Kyoji Horie, Susan E. Bear, George A. Gaitanaris, Philip N. Tsichlis, Ioanna G. Maroulakou, Thomas Ludwig, Esmerina Tili, Marei Dose, Changchuin Mao, Mariëlle C. Haks, Fotini Gounari, David L. Wiest, Vincenzo Fidanza
Publikováno v:
The Journal of Immunology. 178:5443-5453
Pre-TCR signals regulate the transition of the double-negative (DN) 3 thymocytes to the DN4, and subsequently to the double-positive (DP) stage. In this study, we show that pre-TCR signals activate Akt and that pharmacological inhibition of the PI3K/
Autor:
George A. Gaitanaris, Hui Xu, Hongkui Zeng, Hiroki Toyoda, Maria N. Pavlova, John G. Hohmann, John E. Bergmann, Rene Onrust, Alex Rohde, Brian A. Schimpf, Galina Gragerova, Ming Gao Zhao, Alexander Gragerov, Min Zhuo, Long Jun Wu
Publikováno v:
Molecular and Cellular Biology. 26:9352-9363
Neuromedin U (NMU) is a highly conserved neuropeptide with a variety of physiological functions mediated by two receptors, peripheral NMUR1 and central nervous system NMUR2. Here we report the generation and phenotypic characterization of mice defici
Autor:
Roland H. Stauber, George N. Pavlakis, P. Carney, George A. Gaitanaris, E.A. Hudson, N.I. Tarasova, Kyoji Horie
Publikováno v:
BioTechniques. 24:462-471
The introduction of several mutations resulted in the generation of improved mutants of the green fluorescent protein (GFP). A strong green (GFPsg25) and blue (BFPsg50) fluorescent protein, gave 50-fold–100-fold brighter fluorescence compared to wi
Publikováno v:
Virology. 213:439-449
Expression ofgag/polandenvgenes of human immunodeficiency virus requires the viral Rev protein. Mutant Rev proteins, displaying a transdominant phenotype (TDRev), were shown to inhibit Rev function. To investigate the underlying mechanism of this inh
Autor:
Christos A. Panagiotidis, Saul J. Silverstein, Aleksandra Cegielska, William F. Burkholder, George A. Gaitanaris, Max E. Gottesman
Publikováno v:
Journal of Molecular Biology. 242:364-377
A temperature-sensitive mutant of DnaK, the principal Escherichia coli member of the 70 kDa heat shock protein family has been isolated. The mutation, dnaK25, lies in the putative ATP binding pocket of DnaK. It consists of a C to T transition that ch
Publikováno v:
Methods in Molecular Biology ISBN: 9781607619734
A method for random relatively unbiased mutagenesis of ES cells with a mutagenic retroviral vector is described. An orderly assembly of mutant ES cells in multi-well plates is generated. 3D pooling of the wells of the assembly allows quick PCR search
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f99040523debb156660e1588984d5d6
https://doi.org/10.1007/978-1-60761-974-1_17
https://doi.org/10.1007/978-1-60761-974-1_17
Autor:
John E. Bergmann, Maria N. Pavlova, Demetrios K. Vassilatis, Io Dolka, Alex Rhode, Kyoji Horie, Hongkui Zeng, Christopher Navas, George A. Gaitanaris, Alexander Gragerov, Patricia Roth, Amanda Ebbert, Galina Gragerova, Stephanie Moe, Eric E. Finn, George N. Pavlakis, Linda Madisen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 104(36)
We describe the construction of a large-scale, orderly assembly of mutant ES cells, generated with retroviral insertions and having mutational coverage in >90% of mouse genes. We also describe a method for isolating ES cell clones with mutations in s
Autor:
Jane E. Ranchalis, Analisa Brown, Stephanie Rodriguez, Marty Mortrud, Hongkui Zeng, Abbie C. Wright, John G. Hohmann, Fusheng Li, Demetrios K. Vassilatis, John R. Weller, John E. Bergmann, George A. Gaitanaris
Diverse members of the G protein-coupled receptor (GPCR) superfamily participate in a variety of physiological functions and are major targets of pharmaceutical drugs. Here we report that the repertoire of GPCRs for endogenous ligands consists of 367
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458bd245b470ae8bf6d827993f98cefa
https://europepmc.org/articles/PMC153653/
https://europepmc.org/articles/PMC153653/