Zobrazeno 1 - 10
of 26
pro vyhledávání: '"George A. Doherty"'
Autor:
George W. Doherty
Publikováno v:
Traumatology. 10:145-164
Crises in the form of individual events, critical incidents and disasters occur in rural and frontier areas of America just as they do elsewhere. They do have effects on people, and events elsewhere have effects as well. These may occur vicariously (
Autor:
George A. Doherty, Stephen G. Pacholok, Richard A. Mumford, Qian Si, Ermengilda McCauley, Ginger X. Yang, Sharon Tong, William K. Hagmann, Kashmira Shah, Kelly M. Treonz, Gail Van Riper, Gloria C. Koo, Edite Borges
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1891-1895
A series of isonicotinoyl-(L)-aminophenylalanine derivatives was prepared and evaluated as VLA-4 antagonists. These compounds exhibit subnanomolar binding affinity to VLA-4 and significant off-rates. The interplay between off-rate, protein binding an
Autor:
Gloria J.-F. Ding, George A. Doherty, Douglas W. Kawka, William K. Hagmann, Irwin I. Singer, Richard Wnek, Xin Chun Tong, Jianying Xiao, R. Blake Pepinsky, Kashmira Shah, Gloria C. Koo, Lin Kochung
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 167:1400-1409
A nonpeptidyl small molecule antagonist, compound A, to nonactivated very late antigen-4 (VLA4) was examined in lung inflammation induced by a single dose of ovalbumin challenge. Compound A presented a good pharmacokinetic property, when given intrat
Autor:
John A. Schmidt, Plato A. Magriotis, Ermengilda McCauley, Usha Kidambi, George A. Doherty, Richard A. Mumford, Gail Van Riper, Linda L. Chang, Ginger X. Yang, Malcolm MacCoss, Stephen E. de Laszlo, William K. Hagmann, Quang Truong, Linda A. Egger, Bing Li
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1497-1500
Given the proposed involvement of VLA-4 in inflammatory processes, a program to identify orally active VLA-4 antagonists was initiated. Herein, we report the discovery of a N -tetrahydrofuroyl-( l )-phenylalanine derivative ( 17 ) and related analogu
Autor:
George A. Doherty, Barry M. Trost and
Publikováno v:
Journal of the American Chemical Society. 122:3801-3810
A formal synthesis of roseophilin, a novel pentacyclic structure possessing significant antitumor activity, starting from 3-cycloundecenylcarboxylic acid has been completed. The acid was converted diastereoselectively to the corresponding menthol est
Autor:
George W. Doherty
Publikováno v:
PsycCRITIQUES. 57
Autor:
George A. Doherty, Timothy A. Vortherms, Andrew O. Stewart, Kennan C. Marsh, Pramila Bhatia, Jill M. Wetter, Michael F. Jarvis, Helmut Mack, Victoria E. Scott
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(4)
A novel series of diphenyl lactam containing calcium channel blockers is described. Extensive SAR studies resulted in compounds with low molar activity and good plasma exposure after oral dosing. Compounds 2, 6 and 7 demonstrated significant efficacy
Autor:
George A. Doherty, Barry M. Trost
Publikováno v:
ChemInform. 31
Autor:
George W. Doherty
Publikováno v:
PsycCRITIQUES. 52
Autor:
George W. Doherty
Publikováno v:
PsycCRITIQUES. 52